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A Review of Recent Advances in Benchmark Dose Methodology

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  • Signe M. Jensen
  • Felix M. Kluxen
  • Christian Ritz

Abstract

In this review, recent methodological developments for the benchmark dose (BMD) methodology are summarized. Specifically, we introduce the advances for the main steps in BMD derivation: selecting the procedure for defining a BMD from a predefined benchmark response (BMR), setting a BMR, selecting a dose–response model, and estimating the corresponding BMD lower limit (BMDL). Although the last decade has shown major progress in the development of BMD methodology, there is still room for improvement. Remaining challenges are the implementation of new statistical methods in user‐friendly software and the lack of consensus about how to derive the BMDL.

Suggested Citation

  • Signe M. Jensen & Felix M. Kluxen & Christian Ritz, 2019. "A Review of Recent Advances in Benchmark Dose Methodology," Risk Analysis, John Wiley & Sons, vol. 39(10), pages 2295-2315, October.
    • Handle: RePEc:wly:riskan:v:39:y:2019:i:10:p:2295-2315
    DOI: 10.1111/risa.13324
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