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Benchmark Dose Analysis via Nonparametric Regression Modeling

Author

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  • Walter W. Piegorsch
  • Hui Xiong
  • Rabi N. Bhattacharya
  • Lizhen Lin

Abstract

Estimation of benchmark doses (BMDs) in quantitative risk assessment traditionally is based upon parametric dose‐response modeling. It is a well‐known concern, however, that if the chosen parametric model is uncertain and/or misspecified, inaccurate and possibly unsafe low‐dose inferences can result. We describe a nonparametric approach for estimating BMDs with quantal‐response data based on an isotonic regression method, and also study use of corresponding, nonparametric, bootstrap‐based confidence limits for the BMD. We explore the confidence limits’ small‐sample properties via a simulation study, and illustrate the calculations with an example from cancer risk assessment. It is seen that this nonparametric approach can provide a useful alternative for BMD estimation when faced with the problem of parametric model uncertainty.

Suggested Citation

  • Walter W. Piegorsch & Hui Xiong & Rabi N. Bhattacharya & Lizhen Lin, 2014. "Benchmark Dose Analysis via Nonparametric Regression Modeling," Risk Analysis, John Wiley & Sons, vol. 34(1), pages 135-151, January.
    • Handle: RePEc:wly:riskan:v:34:y:2014:i:1:p:135-151
    DOI: 10.1111/risa.12066
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    References listed on IDEAS

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