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Benchmark Dose Estimation Incorporating Multiple Data Sources

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  • Matthew W. Wheeler
  • A. John Bailer

Abstract

With the increased availability of toxicological hazard information arising from multiple experimental sources, risk assessors are often confronted with the challenge of synthesizing all available scientific information into an analysis. This analysis is further complicated because significant between‐source heterogeneity/lab‐to‐lab variability is often evident. We estimate benchmark doses using hierarchical models to account for the observed heterogeneity. These models are used to construct source‐specific and population‐average estimates of the benchmark dose (BMD). This is illustrated with an analysis of the U.S. EPA Region IX's reference toxicity database on the effects of sodium chloride on reproduction in Ceriodaphnia dubia. Results show that such models may effectively account for the lab‐source heterogeneity while producing BMD estimates that more truly reflect the variability of the system under study. Failing to account for such heterogeneity may result in estimates having confidence intervals that are overly narrow.

Suggested Citation

  • Matthew W. Wheeler & A. John Bailer, 2009. "Benchmark Dose Estimation Incorporating Multiple Data Sources," Risk Analysis, John Wiley & Sons, vol. 29(2), pages 249-256, February.
    • Handle: RePEc:wly:riskan:v:29:y:2009:i:2:p:249-256
    DOI: 10.1111/j.1539-6924.2008.01144.x
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    References listed on IDEAS

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    1. David J. Spiegelhalter & Nicola G. Best & Bradley P. Carlin & Angelika Van Der Linde, 2002. "Bayesian measures of model complexity and fit," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 64(4), pages 583-639, October.
    2. David B. Dunson & Zhen Chen & Jean Harry, 2003. "A Bayesian Approach for Joint Modeling of Cluster Size and Subunit-Specific Outcomes," Biometrics, The International Biometric Society, vol. 59(3), pages 521-530, September.
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    Cited by:

    1. Esben Budtz‐Jørgensen & David Bellinger & Bruce Lanphear & Philippe Grandjean & on behalf of the International Pooled Lead Study Investigators, 2013. "An International Pooled Analysis for Obtaining a Benchmark Dose for Environmental Lead Exposure in Children," Risk Analysis, John Wiley & Sons, vol. 33(3), pages 450-461, March.
    2. Signe M. Jensen & Felix M. Kluxen & Christian Ritz, 2019. "A Review of Recent Advances in Benchmark Dose Methodology," Risk Analysis, John Wiley & Sons, vol. 39(10), pages 2295-2315, October.

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