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Data-informed discovery of hydrolytic nanozymes

Author

Listed:
  • Sirong Li

    (Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University)

  • Zijun Zhou

    (Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University)

  • Zuoxiu Tie

    (Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University)

  • Bing Wang

    (Central China Normal University)

  • Meng Ye

    (China Pharmaceutical University)

  • Lei Du

    (Wuhan University)

  • Ran Cui

    (Wuhan University)

  • Wei Liu

    (China Pharmaceutical University)

  • Cuihong Wan

    (Central China Normal University)

  • Quanyi Liu

    (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
    University of Science and Technology of China, Hefei)

  • Sheng Zhao

    (Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University)

  • Quan Wang

    (Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University)

  • Yihong Zhang

    (Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University)

  • Shuo Zhang

    (Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
    Collaborative Innovation Center of Advanced Microstructures and Institute of Materials Engineering Nanjing University)

  • Huigang Zhang

    (Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
    Collaborative Innovation Center of Advanced Microstructures and Institute of Materials Engineering Nanjing University)

  • Yan Du

    (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
    University of Science and Technology of China, Hefei)

  • Hui Wei

    (Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University
    Nanjing University
    Nanjing University)

Abstract

Nanozyme is a collection of nanomaterials with enzyme-like activity but higher environmental tolerance and long-term stability than their natural counterparts. Improving the catalytic activity and expanding the category of nanozymes are prerequisites to complement or even supersede enzymes. However, the development of hydrolytic nanozymes is still challenged by diverse hydrolytic substrates and following complicated mechanisms. Here, two strategies are informed by data to screen and predict catalytic active sites of MOF (metal–organic framework) based hydrolytic nanozymes: (1) to increase the intrinsic activity by finely tuned Lewis acidity of the metal clusters; (2) to improve the density of active sites by shortening the length of ligands. Finally, as-obtained Ce-FMA-MOF-based hydrolytic nanozyme is capable of cleaving phosphate bonds, amide bonds, glycosidic bonds, and even their mixture, biofilms. This work provides a rational methodology to design hydrolytic nanozyme, enriches the diversity of nanozymes, and potentially sheds light on future evolution of enzyme engineering.

Suggested Citation

  • Sirong Li & Zijun Zhou & Zuoxiu Tie & Bing Wang & Meng Ye & Lei Du & Ran Cui & Wei Liu & Cuihong Wan & Quanyi Liu & Sheng Zhao & Quan Wang & Yihong Zhang & Shuo Zhang & Huigang Zhang & Yan Du & Hui We, 2022. "Data-informed discovery of hydrolytic nanozymes," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28344-2
    DOI: 10.1038/s41467-022-28344-2
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    References listed on IDEAS

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    2. Weiqing Xu & Xiaoli Cai & Yu Wu & Yating Wen & Rina Su & Yu Zhang & Yuteng Huang & Qihui Zheng & Liuyong Hu & Xiaowen Cui & Lirong Zheng & Shipeng Zhang & Wenling Gu & Weiyu Song & Shaojun Guo & Cheng, 2023. "Biomimetic single Al-OH site with high acetylcholinesterase-like activity and self-defense ability for neuroprotection," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Kaiyuan Wang & Qing Hong & Caixia Zhu & Yuan Xu & Wang Li & Ying Wang & Wenhao Chen & Xiang Gu & Xinghua Chen & Yanfeng Fang & Yanfei Shen & Songqin Liu & Yuanjian Zhang, 2024. "Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Ying Zhang & Shenqiang Wang & Yinxian Yang & Sheng Zhao & Jiahuan You & Junxia Wang & Jingwei Cai & Hao Wang & Jie Wang & Wei Zhang & Jicheng Yu & Chunmao Han & Yuqi Zhang & Zhen Gu, 2023. "Scarless wound healing programmed by core-shell microneedles," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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