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Scarless wound healing programmed by core-shell microneedles

Author

Listed:
  • Ying Zhang

    (Zhejiang University)

  • Shenqiang Wang

    (Zhejiang University)

  • Yinxian Yang

    (Zhejiang University)

  • Sheng Zhao

    (Zhejiang University)

  • Jiahuan You

    (Zhejiang University)

  • Junxia Wang

    (Zhejiang University)

  • Jingwei Cai

    (Zhejiang University)

  • Hao Wang

    (Zhejiang University)

  • Jie Wang

    (Zhejiang University)

  • Wei Zhang

    (Zhejiang University)

  • Jicheng Yu

    (Zhejiang University
    Zhejiang University
    Jinhua Institute of Zhejiang University
    Zhejiang University Medical Center)

  • Chunmao Han

    (Zhejiang University)

  • Yuqi Zhang

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

  • Zhen Gu

    (Zhejiang University
    Zhejiang University
    Jinhua Institute of Zhejiang University
    Zhejiang University Medical Center)

Abstract

Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at the early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, the ROS-sensitive MN shell gradually degrades to expose the MN core component, which neutralizes various inflammatory factors and promotes the phase transition from inflammation to proliferation. In addition, the released verteporfin inhibits scar formation by blocking Engrailed-1 (En1) activation in fibroblasts. Our experiments demonstrate that PF-MNs promote scarless wound repair in mouse models of both acute and chronic wounds, and inhibit the formation of hypertrophic scar in rabbit ear models.

Suggested Citation

  • Ying Zhang & Shenqiang Wang & Yinxian Yang & Sheng Zhao & Jiahuan You & Junxia Wang & Jingwei Cai & Hao Wang & Jie Wang & Wei Zhang & Jicheng Yu & Chunmao Han & Yuqi Zhang & Zhen Gu, 2023. "Scarless wound healing programmed by core-shell microneedles," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39129-6
    DOI: 10.1038/s41467-023-39129-6
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    References listed on IDEAS

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    1. Jian Zhang & Yongjun Zheng & Jimmy Lee & Jieyu Hua & Shilong Li & Ananth Panchamukhi & Jiping Yue & Xuewen Gou & Zhaofan Xia & Linyong Zhu & Xiaoyang Wu, 2021. "A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Lise Dieltjens & Kenny Appermans & Maries Lissens & Bram Lories & Wook Kim & Erik V. Van der Eycken & Kevin R. Foster & Hans P. Steenackers, 2020. "Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    3. Sophia Maschalidi & Parul Mehrotra & Burcu N. Keçeli & Hannah K. L. Cleene & Kim Lecomte & Renée Cruyssen & Pauline Janssen & Jonathan Pinney & Geert Loo & Dirk Elewaut & Ann Massie & Esther Hoste & K, 2022. "Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes," Nature, Nature, vol. 606(7915), pages 776-784, June.
    4. Michal Sobecki & Ewelina Krzywinska & Shunmugam Nagarajan & Annette Audigé & Khanh Huỳnh & Julian Zacharjasz & Julien Debbache & Yann Kerdiles & Dagmar Gotthardt & Norihiko Takeda & Joachim Fandrey & , 2021. "NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    5. Sirong Li & Zijun Zhou & Zuoxiu Tie & Bing Wang & Meng Ye & Lei Du & Ran Cui & Wei Liu & Cuihong Wan & Quanyi Liu & Sheng Zhao & Quan Wang & Yihong Zhang & Shuo Zhang & Huigang Zhang & Yan Du & Hui We, 2022. "Data-informed discovery of hydrolytic nanozymes," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Sophia Maschalidi & Parul Mehrotra & Burcu N. Keçeli & Hannah K. L. Cleene & Kim Lecomte & Renée Cruyssen & Pauline Janssen & Jonathan Pinney & Geert Loo & Dirk Elewaut & Ann Massie & Esther Hoste & K, 2022. "Author Correction: Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes," Nature, Nature, vol. 608(7923), pages 29-29, August.
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    1. Bin Zheng & Qiuya Li & Laiping Fang & Xiaolu Cai & Yan Liu & Yanhong Duo & Bowen Li & Zhengyu Wu & Boxi Shen & Yang Bai & Shi-Xiang Cheng & Xingcai Zhang, 2024. "Microorganism microneedle micro-engine depth drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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