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Content
May 2018, Volume 557, Issue 7704
- 172-174 Connections that control defence strategy
by Dayu Lin - 174-175 Detailed view of human telomerase enzyme invites rethink of its structure
by Michael D. Stone - 177-182 Diametric neural ensemble dynamics in parkinsonian and dyskinetic states
by Jones G. Parker & Jesse D. Marshall & Biafra Ahanonu & Yu-Wei Wu & Tony Hyun Kim & Benjamin F. Grewe & Yanping Zhang & Jin Zhong Li & Jun B. Ding & Michael D. Ehlers & Mark J. Schnitzer - 183-189 A midline thalamic circuit determines reactions to visual threat
by Lindsey D. Salay & Nao Ishiko & Andrew D. Huberman - 190-195 Cryo-EM structure of substrate-bound human telomerase holoenzyme
by Thi Hoang Duong Nguyen & Jane Tam & Robert A. Wu & Basil J. Greber & Daniel Toso & Eva Nogales & Kathleen Collins - 196-201 Structural basis for dual-mode inhibition of the ABC transporter MsbA
by Hoangdung Ho & Anh Miu & Mary Kate Alexander & Natalie K. Garcia & Angela Oh & Inna Zilberleyb & Mike Reichelt & Cary D. Austin & Christine Tam & Stephanie Shriver & Huiyong Hu & Sharada S. Labadie & Jun Liang & Lan Wang & Jian Wang & Yan Lu & Hans E. Purkey & John Quinn & Yvonne Franke & Kevin Clark & Maureen H. Beresini & Man-Wah Tan & Benjamin D. Sellers & Till Maurer & Michael F. T. Koehler & Aaron T. Wecksler & James R. Kiefer & Vishal Verma & Yiming Xu & Mireille Nishiyama & Jian Payandeh & Christopher M. Koth - 202-206 Electron magnetic reconnection without ion coupling in Earth’s turbulent magnetosheath
by T. D. Phan & J. P. Eastwood & M. A. Shay & J. F. Drake & B. U. Ö. Sonnerup & M. Fujimoto & P. A. Cassak & M. Øieroset & J. L. Burch & R. B. Torbert & A. C. Rager & J. C. Dorelli & D. J. Gershman & C. Pollock & P. S. Pyakurel & C. C. Haggerty & Y. Khotyaintsev & B. Lavraud & Y. Saito & M. Oka & R. E. Ergun & A. Retino & O. Contel & M. R. Argall & B. L. Giles & T. E. Moore & F. D. Wilder & R. J. Strangeway & C. T. Russell & P. A. Lindqvist & W. Magnes - 217-222 Highly durable, coking and sulfur tolerant, fuel-flexible protonic ceramic fuel cells
by Chuancheng Duan & Robert J. Kee & Huayang Zhu & Canan Karakaya & Yachao Chen & Sandrine Ricote & Angelique Jarry & Ethan J. Crumlin & David Hook & Robert Braun & Neal P. Sullivan & Ryan O’Hayre - 223-227 Rapid energy-efficient manufacturing of polymers and composites via frontal polymerization
by Ian D. Robertson & Mostafa Yourdkhani & Polette J. Centellas & Jia En Aw & Douglas G. Ivanoff & Elyas Goli & Evan M. Lloyd & Leon M. Dean & Nancy R. Sottos & Philippe H. Geubelle & Jeffrey S. Moore & Scott R. White - 228-232 Nanoscale synthesis and affinity ranking
by Nathan J. Gesmundo & Bérengère Sauvagnat & Patrick J. Curran & Matthew P. Richards & Christine L. Andrews & Peter J. Dandliker & Tim Cernak - 233-237 Earliest known hominin activity in the Philippines by 709 thousand years ago
by T. Ingicco & G. D. Bergh & C. Jago-on & J.-J. Bahain & M. G. Chacón & N. Amano & H. Forestier & C. King & K. Manalo & S. Nomade & A. Pereira & M. C. Reyes & A.-M. Sémah & Q. Shao & P. Voinchet & C. Falguères & P. C. H. Albers & M. Lising & G. Lyras & D. Yurnaldi & P. Rochette & A. Bautista & J. Vos - 238-241 Lethal trap created by adaptive evolutionary response to an exotic resource
by Michael C. Singer & Camille Parmesan - 242-246 Subepithelial telocytes are an important source of Wnts that supports intestinal crypts
by Michal Shoshkes-Carmel & Yue J. Wang & Kirk J. Wangensteen & Beáta Tóth & Ayano Kondo & Efi E. Massasa & Shalev Itzkovitz & Klaus H. Kaestner - 247-251 De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation
by Johanna R. Schaub & Kari A. Huppert & Simone N. T. Kurial & Bernadette Y. Hsu & Ashley E. Cast & Bryan Donnelly & Rebekah A. Karns & Feng Chen & Milad Rezvani & Hubert Y. Luu & Aras N. Mattis & Anne-Laure Rougemont & Philip Rosenthal & Stacey S. Huppert & Holger Willenbring - 252-255 Male-killing toxin in a bacterial symbiont of Drosophila
by Toshiyuki Harumoto & Bruno Lemaitre - 256-260 Chromatin analysis in human early development reveals epigenetic transition during ZGA
by Jingyi Wu & Jiawei Xu & Bofeng Liu & Guidong Yao & Peizhe Wang & Zili Lin & Bo Huang & Xuepeng Wang & Tong Li & Senlin Shi & Nan Zhang & Fuyu Duan & Jia Ming & Xiangyang Zhang & Wenbin Niu & Wenyan Song & Haixia Jin & Yihong Guo & Shanjun Dai & Linli Hu & Lanlan Fang & Qiujun Wang & Yuanyuan Li & Wei Li & Jie Na & Wei Xie & Yingpu Sun - 261-265 Structural principles of distinct assemblies of the human α4β2 nicotinic receptor
by Richard M. Walsh & Soung-Hun Roh & Anant Gharpure & Claudio L. Morales-Perez & Jinfeng Teng & Ryan E. Hibbs - 267-269 How to handle the dark days of depression
by Emily Sohn - 269-269 Write fiction to discover something new in your research
by Amanda C. Niehaus - 272-272 Blue sky research
by Ian Stewart
May 2018, Volume 557, Issue 7703
- 7-7 To treat pain, study people in all their complexity
by Beth Darnall - 13-14 Mars quakes set to reveal tantalizing clues to planet’s early years
by Alexandra Witze - 14-15 Giving at-risk children pre-emptive antibiotics reduces deaths
by Amy Maxmen - 15-16 Physicists in Earth’s remotest corners race to reproduce ‘cosmic dawn’ signal
by Davide Castelvecchi - 16-17 Scientists downsize bold plan to make human genome from scratch
by Elie Dolgin - 17-17 Brazil’s lawmakers renew push to weaken environmental rules
by Jeff Tollefson - 18-18 Billion-star map of Milky Way set to transform astronomy
by Davide Castelvecchi - 19-24 Colombia: After the violence
by Sara Reardon - 25-27 Close the gender gap in Chinese science
by Ying Ma & Yandong Zhao & Xu Gong & Li Sun & Yonghe Zheng - 28-29 The forgotten founder of ornithology
by Elizabeth Yale - 29-29 Where colour comes from, the secret lives of fish and growth in democracies: Books in brief
by Barbara Kiser - 30-30 Did Einstein really say that?
by Andrew Robinson - 31-31 Data reviews quick to produce but open to abuse
by Yong Fan - 31-31 AI surveillance studies need ethics review
by Rafael A. Calvo & Dorian Peters - 31-31 Sea-bed mining — count the true costs
by Sebastian Losada & Pierre Terras - 31-31 Shore up support for climate action using SDGs
by Francesco Fuso Nerini - 31-31 Nobel prize lagged my undergraduate lectures by 20 years
by William Bains - 34-35 Faulty replication can sting
by Madzia P. Crossley & Karlene A. Cimprich - 35-36 Helium discovered in the tail of an exoplanet
by Drake Deming - 36-37 Evolutionary insights from an ancient bird
by Kevin Padian - 38-39 Perfect union of protein and gel creates hyperexpandable crystals
by François Baneyx - 39-40 Molecular machines swap rings
by Steve Goldup - 40-41 Life of a liver awaiting transplantation
by Stefan Schneeberger - 43-49 Genomic variation in 3,010 diverse accessions of Asian cultivated rice
by Wensheng Wang & Ramil Mauleon & Zhiqiang Hu & Dmytro Chebotarov & Shuaishuai Tai & Zhichao Wu & Min Li & Tianqing Zheng & Roven Rommel Fuentes & Fan Zhang & Locedie Mansueto & Dario Copetti & Millicent Sanciangco & Kevin Christian Palis & Jianlong Xu & Chen Sun & Binying Fu & Hongliang Zhang & Yongming Gao & Xiuqin Zhao & Fei Shen & Xiao Cui & Hong Yu & Zichao Li & Miaolin Chen & Jeffrey Detras & Yongli Zhou & Xinyuan Zhang & Yue Zhao & Dave Kudrna & Chunchao Wang & Rui Li & Ben Jia & Jinyuan Lu & Xianchang He & Zhaotong Dong & Jiabao Xu & Yanhong Li & Miao Wang & Jianxin Shi & Jing Li & Dabing Zhang & Seunghee Lee & Wushu Hu & Alexander Poliakov & Inna Dubchak & Victor Jun Ulat & Frances Nikki Borja & John Robert Mendoza & Jauhar Ali & Jing Li & Qiang Gao & Yongchao Niu & Zhen Yue & Ma. Elizabeth B. Naredo & Jayson Talag & Xueqiang Wang & Jinjie Li & Xiaodong Fang & Ye Yin & Jean-Christophe Glaszmann & Jianwei Zhang & Jiayang Li & Ruaraidh Sackville Hamilton & Rod A. Wing & Jue Ruan & Gengyun Zhang & Chaochun Wei & Nickolai Alexandrov & Kenneth L. McNally & Zhikang Li & Hei Leung - 50-56 A randomized trial of normothermic preservation in liver transplantation
by David Nasralla & Constantin C. Coussios & Hynek Mergental & M. Zeeshan Akhtar & Andrew J. Butler & Carlo D. L. Ceresa & Virginia Chiocchia & Susan J. Dutton & Juan Carlos García-Valdecasas & Nigel Heaton & Charles Imber & Wayel Jassem & Ina Jochmans & John Karani & Simon R. Knight & Peri Kocabayoglu & Massimo Malagò & Darius Mirza & Peter J. Morris & Arvind Pallan & Andreas Paul & Mihai Pavel & M. Thamara P. R. Perera & Jacques Pirenne & Reena Ravikumar & Leslie Russell & Sara Upponi & Chris J. E. Watson & Annemarie Weissenbacher & Rutger J. Ploeg & Peter J. Friend - 57-61 SAMHD1 acts at stalled replication forks to prevent interferon induction
by Flavie Coquel & Maria-Joao Silva & Hervé Técher & Karina Zadorozhny & Sushma Sharma & Jadwiga Nieminuszczy & Clément Mettling & Elodie Dardillac & Antoine Barthe & Anne-Lyne Schmitz & Alexy Promonet & Alexandra Cribier & Amélie Sarrazin & Wojciech Niedzwiedz & Bernard Lopez & Vincenzo Costanzo & Lumir Krejci & Andrei Chabes & Monsef Benkirane & Yea-Lih Lin & Philippe Pasero - 62-67 Cryo-EM structure of the gasdermin A3 membrane pore
by Jianbin Ruan & Shiyu Xia & Xing Liu & Judy Lieberman & Hao Wu - 68-70 Helium in the eroding atmosphere of an exoplanet
by J. J. Spake & D. K. Sing & T. M. Evans & A. Oklopčić & V. Bourrier & L. Kreidberg & B. V. Rackham & J. Irwin & D. Ehrenreich & A. Wyttenbach & H. R. Wakeford & Y. Zhou & K. L. Chubb & N. Nikolov & J. M. Goyal & G. W. Henry & M. H. Williamson & S. Blumenthal & D. R. Anderson & C. Hellier & D. Charbonneau & S. Udry & N. Madhusudhan - 71-75 Characterization of the 1S–2S transition in antihydrogen
by M. Ahmadi & B. X. R. Alves & C. J. Baker & W. Bertsche & A. Capra & C. Carruth & C. L. Cesar & M. Charlton & S. Cohen & R. Collister & S. Eriksson & A. Evans & N. Evetts & J. Fajans & T. Friesen & M. C. Fujiwara & D. R. Gill & J. S. Hangst & W. N. Hardy & M. E. Hayden & C. A. Isaac & M. A. Johnson & J. M. Jones & S. A. Jones & S. Jonsell & A. Khramov & P. Knapp & L. Kurchaninov & N. Madsen & D. Maxwell & J. T. K. McKenna & S. Menary & T. Momose & J. J. Munich & K. Olchanski & A. Olin & P. Pusa & C. Ø. Rasmussen & F. Robicheaux & R. L. Sacramento & M. Sameed & E. Sarid & D. M. Silveira & G. Stutter & C. So & T. D. Tharp & R. I. Thompson & D. P. Werf & J. S. Wurtele - 76-80 Lightwave valleytronics in a monolayer of tungsten diselenide
by F. Langer & C. P. Schmid & S. Schlauderer & M. Gmitra & J. Fabian & P. Nagler & C. Schüller & T. Korn & P. G. Hawkins & J. T. Steiner & U. Huttner & S. W. Koch & M. Kira & R. Huber - 81-85 An optical-frequency synthesizer using integrated photonics
by Daryl T. Spencer & Tara Drake & Travis C. Briles & Jordan Stone & Laura C. Sinclair & Connor Fredrick & Qing Li & Daron Westly & B. Robert Ilic & Aaron Bluestone & Nicolas Volet & Tin Komljenovic & Lin Chang & Seung Hoon Lee & Dong Yoon Oh & Myoung-Gyun Suh & Ki Youl Yang & Martin H. P. Pfeiffer & Tobias J. Kippenberg & Erik Norberg & Luke Theogarajan & Kerry Vahala & Nathan R. Newbury & Kartik Srinivasan & John E. Bowers & Scott A. Diddams & Scott B. Papp - 86-91 Hyperexpandable, self-healing macromolecular crystals with integrated polymer networks
by Ling Zhang & Jake B. Bailey & Rohit H. Subramanian & Alexander Groisman & F. Akif Tezcan - 92-95 Synthesis, structure and reaction chemistry of a nucleophilic aluminyl anion
by Jamie Hicks & Petra Vasko & Jose M. Goicoechea & Simon Aldridge - 96-100 Complete Ichthyornis skull illuminates mosaic assembly of the avian head
by Daniel J. Field & Michael Hanson & David Burnham & Laura E. Wilson & Kristopher Super & Dana Ehret & Jun A. Ebersole & Bhart-Anjan S. Bhullar - 101-105 Deep mitochondrial origin outside the sampled alphaproteobacteria
by Joran Martijn & Julian Vosseberg & Lionel Guy & Pierre Offre & Thijs J. G. Ettema - 106-111 Blastocyst-like structures generated solely from stem cells
by Nicolas C. Rivron & Javier Frias-Aldeguer & Erik J. Vrij & Jean-Charles Boisset & Jeroen Korving & Judith Vivié & Roman K. Truckenmüller & Alexander Oudenaarden & Clemens A. Blitterswijk & Niels Geijsen - 112-117 LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis
by Nieves Peltzer & Maurice Darding & Antonella Montinaro & Peter Draber & Helena Draberova & Sebastian Kupka & Eva Rieser & Amanda Fisher & Ciaran Hutchinson & Lucia Taraborrelli & Torsten Hartwig & Elodie Lafont & Tobias L. Haas & Yutaka Shimizu & Charlotta Böiers & Aida Sarr & James Rickard & Silvia Alvarez-Diaz & Michael T. Ashworth & Allison Beal & Tariq Enver & John Bertin & William Kaiser & Andreas Strasser & John Silke & Philippe Bouillet & Henning Walczak - 118-122 Architecture of an HIV-1 reverse transcriptase initiation complex
by Kevin P. Larsen & Yamuna Kalyani Mathiharan & Kalli Kappel & Aaron T. Coey & Dong-Hua Chen & Daniel Barrero & Lauren Madigan & Joseph D. Puglisi & Georgios Skiniotis & Elisabetta Viani Puglisi - 123-126 Structure of the alternative complex III in a supercomplex with cytochrome oxidase
by Chang Sun & Samir Benlekbir & Padmaja Venkatakrishnan & Yuhang Wang & Sangjin Hong & Jonathan Hosler & Emad Tajkhorshid & John L. Rubinstein & Robert B. Gennis - 127-128 Virtual-reality applications give science a new dimension
by David Matthews - 129-131 Feeling overwhelmed by academia? You are not alone
by Chris Woolston - 131-131 Political expatriate
by Brian Owens - 134-134 Piano concerto for new hands
by Andrea Kriz
April 2018, Volume 556, Issue 7702
- 409-409 A lab co-op helps young faculty members to thrive
by Rebecca Heald - 415-416 Clear signs of global warming will hit poorer countries first
by Quirin Schiermeier - 416-417 Scientists’ early grant success fuels further funding
by Holly Else - 417-418 US government considers charging for popular Earth-observing data
by Gabriel Popkin - 418-418 Rent increase hits Europe’s drug regulator before Brexit move
by Inga Vesper - 419-419 Mars probe poised to solve red planet’s methane mystery
by Nisha Gaind - 420-420 Flu virus finally sequenced in its native form
by Ewen Callaway - 422-425 Can the world kick its fossil-fuel addiction fast enough?
by Jeff Tollefson - 426-428 Is ‘friendly fire’ in the brain provoking Alzheimer’s disease?
by Alison Abbott - 429-432 The ethics of experimenting with human brain tissue
by Nita A. Farahany & Henry T. Greely & Steven Hyman & Christof Koch & Christine Grady & Sergiu P. Pașca & Nenad Sestan & Paola Arlotta & James L. Bernat & Jonathan Ting & Jeantine E. Lunshof & Eswar P. R. Iyer & Insoo Hyun & Beatrice H. Capestany & George M. Church & Hao Huang & Hongjun Song - 434-435 Where the wild tales are: how stories teach kids to nurture nature
by S. F. Said - 435-435 A visceral history of dinosaurs, the world through the nose of a dog and the psychological secrets of the plot twist: Books in brief
by Barbara Kiser - 436-436 Make codes for research integrity practical
by Maura Hiney - 436-436 Canadian cod comeback derailed
by Sherrylynn Rowe & George A. Rose - 436-436 Order must spring from chaos in Italian research
by Gerry Melino - 436-436 Cap drug prices with policy – here’s how
by Leah Cairns - 436-436 Geoengineering might speed glacier melt
by Twila A. Moon - 438-439 Classic reaction re-engineered through molecular face recognition
by Tobias Morack & Ryan Gilmour - 439-440 A broader look at adolescents with perinatal HIV
by Patricia M. Flynn - 440-440 Shrimp cause a stir
by Henry Gee - 441-442 Organoids reveal cancer dynamics
by Calvin J. Kuo & Christina Curtis - 442-444 Transition states that allow cancer to spread
by Erik W. Thompson & Shivashankar H. Nagaraj - 444-445 Entangled vibrations in mechanical oscillators
by Andrew Armour - 445-446 Hunger is a gatekeeper of pain in the brain
by Alexey Ponomarenko & Tatiana Korotkova - 447-451 Quaternary stereocentres via an enantioconvergent catalytic SN1 reaction
by Alison E. Wendlandt & Prithvi Vangal & Eric N. Jacobsen - 452-456 Renewing Felsenstein’s phylogenetic bootstrap in the era of big data
by F. Lemoine & J.-B. Domelevo Entfellner & E. Wilkinson & D. Correia & M. Dávila Felipe & T. Oliveira & O. Gascuel - 457-462 Intra-tumour diversification in colorectal cancer at the single-cell level
by Sophie F. Roerink & Nobuo Sasaki & Henry Lee-Six & Matthew D. Young & Ludmil B. Alexandrov & Sam Behjati & Thomas J. Mitchell & Sebastian Grossmann & Howard Lightfoot & David A. Egan & Apollo Pronk & Niels Smakman & Joost Gorp & Elizabeth Anderson & Stephen J. Gamble & Chris Alder & Marc Wetering & Peter J. Campbell & Michael R. Stratton & Hans Clevers - 463-468 Identification of the tumour transition states occurring during EMT
by Ievgenia Pastushenko & Audrey Brisebarre & Alejandro Sifrim & Marco Fioramonti & Tatiana Revenco & Soufiane Boumahdi & Alexandra Van Keymeulen & Daniel Brown & Virginie Moers & Sophie Lemaire & Sarah De Clercq & Esmeralda Minguijón & Cédric Balsat & Youri Sokolow & Christine Dubois & Florian De Cock & Samuel Scozzaro & Federico Sopena & Angel Lanas & Nicky D’Haene & Isabelle Salmon & Jean-Christophe Marine & Thierry Voet & Panagiota A. Sotiropoulou & Cédric Blanpain - 469-472 A massive core for a cluster of galaxies at a redshift of 4.3
by T. B. Miller & S. C. Chapman & M. Aravena & M. L. N. Ashby & C. C. Hayward & J. D. Vieira & A. Weiß & A. Babul & M. Béthermin & C. M. Bradford & M. Brodwin & J. E. Carlstrom & Chian-Chou Chen & D. J. M. Cunningham & C. Breuck & A. H. Gonzalez & T. R. Greve & J. Harnett & Y. Hezaveh & K. Lacaille & K. C. Litke & J. Ma & M. Malkan & D. P. Marrone & W. Morningstar & E. J. Murphy & D. Narayanan & E. Pass & R. Perry & K. A. Phadke & D. Rennehan & K. M. Rotermund & J. Simpson & J. S. Spilker & J. Sreevani & A. A. Stark & M. L. Strandet & A. L. Strom - 473-477 Remote quantum entanglement between two micromechanical oscillators
by Ralf Riedinger & Andreas Wallucks & Igor Marinković & Clemens Löschnauer & Markus Aspelmeyer & Sungkun Hong & Simon Gröblacher - 478-482 Stabilized entanglement of massive mechanical oscillators
by C. F. Ockeloen-Korppi & E. Damskägg & J.-M. Pirkkalainen & M. Asjad & A. A. Clerk & F. Massel & M. J. Woolley & M. A. Sillanpää - 483-486 Low-loss plasmon-assisted electro-optic modulator
by Christian Haffner & Daniel Chelladurai & Yuriy Fedoryshyn & Arne Josten & Benedikt Baeuerle & Wolfgang Heni & Tatsuhiko Watanabe & Tong Cui & Bojun Cheng & Soham Saha & Delwin L. Elder & Larry. R. Dalton & Alexandra Boltasseva & Vladimir M. Shalaev & Nathaniel Kinsey & Juerg Leuthold - 487-491 Earthquake-induced transformation of the lower crust
by Bjørn Jamtveit & Yehuda Ben-Zion & François Renard & Håkon Austrheim - 492-496 Global warming transforms coral reef assemblages
by Terry P. Hughes & James T. Kerry & Andrew H. Baird & Sean R. Connolly & Andreas Dietzel & C. Mark Eakin & Scott F. Heron & Andrew S. Hoey & Mia O. Hoogenboom & Gang Liu & Michael J. McWilliam & Rachel J. Pears & Morgan S. Pratchett & William J. Skirving & Jessica S. Stella & Gergely Torda - 497-500 Vertically migrating swimmers generate aggregation-scale eddies in a stratified column
by Isabel A. Houghton & Jeffrey R. Koseff & Stephen G. Monismith & John O. Dabiri - 501-504 Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
by Monika Bambouskova & Laurent Gorvel & Vicky Lampropoulou & Alexey Sergushichev & Ekaterina Loginicheva & Kendall Johnson & Daniel Korenfeld & Mary Elizabeth Mathyer & Hyeryun Kim & Li-Hao Huang & Dustin Duncan & Howard Bregman & Abdurrahman Keskin & Andrea Santeford & Rajendra S. Apte & Raghav Sehgal & Britney Johnson & Gaya K. Amarasinghe & Miguel P. Soares & Takashi Satoh & Shizuo Akira & Tsonwin Hai & Cristina Guzman Strong & Karine Auclair & Thomas P. Roddy & Scott A. Biller & Marko Jovanovic & Eynav Klechevsky & Kelly M. Stewart & Gwendalyn J. Randolph & Maxim N. Artyomov - 505-509 Genetic identification of leptin neural circuits in energy and glucose homeostases
by Jie Xu & Christopher L. Bartolome & Cho Shing Low & Xinchi Yi & Cheng-Hao Chien & Peng Wang & Dong Kong - 510-514 Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells
by Hong Sook Kim & Yuliang Tan & Wubin Ma & Daria Merkurjev & Eugin Destici & Qi Ma & Tom Suter & Kenneth Ohgi & Meyer Friedman & Dorota Skowronska-Krawczyk & Michael G. Rosenfeld - 515-519 Mechanism of NMDA receptor channel block by MK-801 and memantine
by Xianqiang Song & Morten Ø. Jensen & Vishwanath Jogini & Richard A. Stein & Chia-Hsueh Lee & Hassane S. Mchaourab & David E. Shaw & Eric Gouaux - 520-524 Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor
by Zhenlin Yang & Shuo Han & Max Keller & Anette Kaiser & Brian J. Bender & Mathias Bosse & Kerstin Burkert & Lisa M. Kögler & David Wifling & Guenther Bernhardt & Nicole Plank & Timo Littmann & Peter Schmidt & Cuiying Yi & Beibei Li & Sheng Ye & Rongguang Zhang & Bo Xu & Dan Larhammar & Raymond C. Stevens & Daniel Huster & Jens Meiler & Qiang Zhao & Annette G. Beck-Sickinger & Armin Buschauer & Beili Wu - 525-527 A photo celebration of scientists at work
by Jack Leeming - 530-530 My favourite sentience
by Marissa Lingen
April 2018, Volume 556, Issue 7701
- 275-275 Science must rise up to support people like me
by Aaron Schaal - 281-282 Great Barrier Reef saw huge losses from 2016 heatwave
by Quirin Schiermeier - 282-283 East Asia braces for surge in deadly tick-borne virus
by David Cyranoski - 283-283 US environmental group wins millions to develop methane-monitoring satellite
by Jeff Tollefson - 284-284 Air-pollution trackers seek to fill Africa’s data gap
by Nicole Wetsman - 285-285 Spain’s biggest-ever science petition decries ‘abandonment’ of research
by Michele Catanzaro - 285-286 Attacks in UK and Syria highlight growing need for chemical-forensics expertise
by Declan Butler - 287-289 How to blow up a star
by Elizabeth Gibney - 290-292 Medicine’s secret ingredient — it’s in the timing
by Lynne Peeples - 293-295 How to curb production of chemical weapons
by Leiv K. Sydnes - 296-298 Regulate artificial intelligence to avert cyber arms race
by Mariarosaria Taddeo & Luciano Floridi - 300-301 How to retool our concept of value
by Robert Costanza - 301-302 The trouble with the Nobel prize
by Ron Cowen - 302-308 Talking sense on climate change, the biology of behaviour and a prehistoric shark with a twist: New in paperback
by Mary Craig - 303-304 When feathers flew at a natural-history archive
by Stuart Pimm - 304-305 The illusion of time
by Andrew Jaffe - 306-307 War and peace and summer camp
by Alex Haslam - 308-308 The long search for the pain gene
by Tor Wager - 309-309 A repository for quality-assured data on enzyme activity
by Neil Swainston & Carsten Kettner - 309-309 Long-term tracking of biodiversity is more important than ever
by Lisa Norton - 309-309 Code reviewing puts extra demands on referees
by Nicolas P. Rougier & Konrad Hinsen - 309-309 Sharp rise in premier papers from Brazilian universities
by Gabriel José de Carli & Tiago Campos Pereira - 309-309 Steer cancer funding to align with clinical goals
by Johnathan Watkins & Wahyu Wulaningsih - 312-313 Immune memory in the brain
by Alexi Nott & Christopher K. Glass - 313-314 Peptides used to make light-twisting nanoparticles
by Guillermo González-Rubio & Luis M. Liz-Marzán - 315-316 When sex differences lead to extinction
by Hanna Kokko - 316-318 Electronics and photonics united
by Goran Z. Mashanovich - 318-319 A stockpile of antiviral defences
by Sébastien Levesque & Sylvain Moineau - 319-320 Bounteous black holes at the Galactic Centre
by Mark R. Morris - 321-325 Laser spectroscopic characterization of the nuclear-clock isomer 229mTh
by Johannes Thielking & Maxim V. Okhapkin & Przemysław Głowacki & David M. Meier & Lars Wense & Benedict Seiferle & Christoph E. Düllmann & Peter G. Thirolf & Ekkehard Peik - 326-331 Functional circuit architecture underlying parental behaviour
by Johannes Kohl & Benedicte M. Babayan & Nimrod D. Rubinstein & Anita E. Autry & Brenda Marin-Rodriguez & Vikrant Kapoor & Kazunari Miyamishi & Larry S. Zweifel & Liqun Luo & Naoshige Uchida & Catherine Dulac - 332-338 Innate immune memory in the brain shapes neurological disease hallmarks
by Ann-Christin Wendeln & Karoline Degenhardt & Lalit Kaurani & Michael Gertig & Thomas Ulas & Gaurav Jain & Jessica Wagner & Lisa M. Häsler & Katleen Wild & Angelos Skodras & Thomas Blank & Ori Staszewski & Moumita Datta & Tonatiuh Pena Centeno & Vincenzo Capece & Md. Rezaul Islam & Cemil Kerimoglu & Matthias Staufenbiel & Joachim L. Schultze & Marc Beyer & Marco Prinz & Mathias Jucker & André Fischer & Jonas J. Neher - 339-344 Genome evolution across 1,011 Saccharomyces cerevisiae isolates
by Jackson Peter & Matteo De Chiara & Anne Friedrich & Jia-Xing Yue & David Pflieger & Anders Bergström & Anastasie Sigwalt & Benjamin Barre & Kelle Freel & Agnès Llored & Corinne Cruaud & Karine Labadie & Jean-Marc Aury & Benjamin Istace & Kevin Lebrigand & Pascal Barbry & Stefan Engelen & Arnaud Lemainque & Patrick Wincker & Gianni Liti & Joseph Schacherer - 345-348 Two separate outflows in the dual supermassive black hole system NGC 6240
by F. Müller-Sánchez & R. Nevin & J. M. Comerford & R. I. Davies & G. C. Privon & E. Treister - 349-354 Integrating photonics with silicon nanoelectronics for the next generation of systems on a chip
by Amir H. Atabaki & Sajjad Moazeni & Fabio Pavanello & Hayk Gevorgyan & Jelena Notaros & Luca Alloatti & Mark T. Wade & Chen Sun & Seth A. Kruger & Huaiyu Meng & Kenaish Al Qubaisi & Imbert Wang & Bohan Zhang & Anatol Khilo & Christopher V. Baiocco & Miloš A. Popović & Vladimir M. Stojanović & Rajeev J. Ram - 355-359 A library of atomically thin metal chalcogenides
by Jiadong Zhou & Junhao Lin & Xiangwei Huang & Yao Zhou & Yu Chen & Juan Xia & Hong Wang & Yu Xie & Huimei Yu & Jincheng Lei & Di Wu & Fucai Liu & Qundong Fu & Qingsheng Zeng & Chuang-Han Hsu & Changli Yang & Li Lu & Ting Yu & Zexiang Shen & Hsin Lin & Boris I. Yakobson & Qian Liu & Kazu Suenaga & Guangtong Liu & Zheng Liu - 360-365 Amino-acid- and peptide-directed synthesis of chiral plasmonic gold nanoparticles
by Hye-Eun Lee & Hyo-Yong Ahn & Jungho Mun & Yoon Young Lee & Minkyung Kim & Nam Heon Cho & Kiseok Chang & Wook Sung Kim & Junsuk Rho & Ki Tae Nam - 366-369 High male sexual investment as a driver of extinction in fossil ostracods
by Maria João Fernandes Martins & T. Markham Puckett & Rowan Lockwood & John P. Swaddle & Gene Hunt - 370-375 Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size
by Matthew B. Johnson & Xingshen Sun & Andrew Kodani & Rebeca Borges-Monroy & Kelly M. Girskis & Steven C. Ryu & Peter P. Wang & Komal Patel & Dilenny M. Gonzalez & Yu Mi Woo & Ziying Yan & Bo Liang & Richard S. Smith & Manavi Chatterjee & Daniel Coman & Xenophon Papademetris & Lawrence H. Staib & Fahmeed Hyder & Joseph B. Mandeville & P. Ellen Grant & Kiho Im & Hojoong Kwak & John F. Engelhardt & Christopher A. Walsh & Byoung-Il Bae - 376-380 An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis
by Kifayathullah Liakath-Ali & Eric W. Mills & Inês Sequeira & Beate M. Lichtenberger & Angela Oliveira Pisco & Kalle H. Sipilä & Ajay Mishra & Harunori Yoshikawa & Colin Chih-Chien Wu & Tony Ly & Angus I. Lamond & Ibrahim M. Adham & Rachel Green & Fiona M. Watt - 381-385 Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity
by Kuan-Chuan Pao & Nicola T. Wood & Axel Knebel & Karim Rafie & Mathew Stanley & Peter D. Mabbitt & Ramasubramanian Sundaramoorthy & Kay Hofmann & Daan M. F. Aalten & Satpal Virdee - 386-390 Structural basis for ATP-dependent chromatin remodelling by the INO80 complex
by Sebastian Eustermann & Kevin Schall & Dirk Kostrewa & Kristina Lakomek & Mike Strauss & Manuela Moldt & Karl-Peter Hopfner - 391-395 Structure and regulation of the human INO80–nucleosome complex
by Rafael Ayala & Oliver Willhoft & Ricardo J. Aramayo & Martin Wilkinson & Elizabeth A. McCormack & Lorraine Ocloo & Dale B. Wigley & Xiaodong Zhang - 397-398 YouTube your science
by Adrian A. Smith - 399-399 Space pioneer
by Virginia Gewin - 402-402 Wasteland of sand and ice
by Tomás McMahon
April 2018, Volume 556, Issue 7700
- 1-3 Collaboration is the key to cancer research
by Neil Savage - 151-151 Demand cancer drugs that truly help patients
by Ajay Aggarwal - 157-158 Beijing launches pioneering brain-science centre
by David Cyranoski - 158-159 NASA’s next exoplanet hunter will seek worlds close to home
by Alexandra Witze - 160-160 Science’s vast gender pay gap revealed in UK wage data
by Holly Else - 161-161 Plan to dismantle Puerto Rico’s statistics agency gets green light
by Giorgia Guglielmi - 161-162 Cutting-edge cancer drug hobbled by diagnostic test confusion
by Heidi Ledford - 164-168 How gravitational waves could solve some of the Universe’s deepest mysteries
by Davide Castelvecchi - 169-171 People must retain control of autonomous vehicles
by Ashley Nunes & Bryan Reimer & Joseph F. Coughlin - 172-173 A physicist probes the metaphysical
by Anil Ananthaswamy - 173-173 The deep past of megafires, big data’s Achilles heel and behind the scenes of the March for Science: Books in brief
by Barbara Kiser - 174-174 Build two-way rapport for better policymaking
by Adam P. Hejnowicz & Sue E. Hartley & Nigel Gilbert - 174-174 Save a North Sea fish from becoming museum piece
by Jon C. Svendsen & Aage K. O. Alstrup & Lasse F. Jensen - 174-174 Take a holistic view when making pesticide policies stricter
by Robert Finger - 174-174 Don’t dismiss citations to journals not published in English
by Vladimir S. Lazarev & Serhii A. Nazarovets - 174-174 Curtail climate-change effects using Singapore Index of Cities’ Biodiversity
by Sameen Ahmed Khan - 176-177 The certainty of quantum randomness
by Stefano Pironio - 177-178 Mirrors made of a single atomic layer
by Kin Fai Mak & Jie Shan - 178-179 Peptide signal alerts plants to drought
by Alexander Christmann & Erwin Grill - 180-181 North Atlantic circulation slows down
by Summer K. Praetorius - 181-182 The telomerase enzyme and liver renewal
by Kenneth S. Zaret - 182-183 Backbone of RNA viruses uncovered
by Mark Zeller & Kristian G. Andersen - 185-190 Reversible Mn2+/Mn4+ double redox in lithium-excess cathode materials
by Jinhyuk Lee & Daniil A. Kitchaev & Deok-Hwang Kwon & Chang-Wook Lee & Joseph K. Papp & Yi-Sheng Liu & Zhengyan Lun & Raphaële J. Clément & Tan Shi & Bryan D. McCloskey & Jinghua Guo & Mahalingam Balasubramanian & Gerbrand Ceder - 191-196 Observed fingerprint of a weakening Atlantic Ocean overturning circulation
by L. Caesar & S. Rahmstorf & A. Robinson & G. Feulner & V. Saba - 197-202 The evolutionary history of vertebrate RNA viruses
by Mang Shi & Xian-Dan Lin & Xiao Chen & Jun-Hua Tian & Liang-Jun Chen & Kun Li & Wen Wang & John-Sebastian Eden & Jin-Jin Shen & Li Liu & Edward C. Holmes & Yong-Zhen Zhang - 203-208 Cryo-EM structure of the Blastochloris viridis LH1–RC complex at 2.9 Å
by Pu Qian & C. Alistair Siebert & Peiyi Wang & Daniel P. Canniffe & C. Neil Hunter - 209-213 Structure of photosynthetic LH1–RC supercomplex at 1.9 Å resolution
by Long-Jiang Yu & Michihiro Suga & Zheng-Yu Wang-Otomo & Jian-Ren Shen - 214-218 Crystal structures of the gastric proton pump
by Kazuhiro Abe & Katsumasa Irie & Hanayo Nakanishi & Hiroshi Suzuki & Yoshinori Fujiyoshi - 219-222 Alteration of the magnetosphere of the Vela pulsar during a glitch
by Jim Palfreyman & John M. Dickey & Aidan Hotan & Simon Ellingsen & Willem Straten - 223-226 Experimentally generated randomness certified by the impossibility of superluminal signals
by Peter Bierhorst & Emanuel Knill & Scott Glancy & Yanbao Zhang & Alan Mink & Stephen Jordan & Andrea Rommal & Yi-Kai Liu & Bradley Christensen & Sae Woo Nam & Martin J. Stevens & Lynden K. Shalm - 227-230 Anomalously weak Labrador Sea convection and Atlantic overturning during the past 150 years
by David J. R. Thornalley & Delia W. Oppo & Pablo Ortega & Jon I. Robson & Chris M. Brierley & Renee Davis & Ian R. Hall & Paola Moffa-Sanchez & Neil L. Rose & Peter T. Spooner & Igor Yashayaev & Lloyd D. Keigwin - 231-234 Accelerated increase in plant species richness on mountain summits is linked to warming
by Manuel J. Steinbauer & John-Arvid Grytnes & Gerald Jurasinski & Aino Kulonen & Jonathan Lenoir & Harald Pauli & Christian Rixen & Manuela Winkler & Manfred Bardy-Durchhalter & Elena Barni & Anne D. Bjorkman & Frank T. Breiner & Sarah Burg & Patryk Czortek & Melissa A. Dawes & Anna Delimat & Stefan Dullinger & Brigitta Erschbamer & Vivian A. Felde & Olatz Fernández-Arberas & Kjetil F. Fossheim & Daniel Gómez-García & Damien Georges & Erlend T. Grindrud & Sylvia Haider & Siri V. Haugum & Hanne Henriksen & María J. Herreros & Bogdan Jaroszewicz & Francesca Jaroszynska & Robert Kanka & Jutta Kapfer & Kari Klanderud & Ingolf Kühn & Andrea Lamprecht & Magali Matteodo & Umberto Morra Cella & Signe Normand & Arvid Odland & Siri L. Olsen & Sara Palacio & Martina Petey & Veronika Piscová & Blazena Sedlakova & Klaus Steinbauer & Veronika Stöckli & Jens-Christian Svenning & Guido Teppa & Jean-Paul Theurillat & Pascal Vittoz & Sarah J. Woodin & Niklaus E. Zimmermann & Sonja Wipf - 235-238 A small peptide modulates stomatal control via abscisic acid in long-distance signalling
by Fuminori Takahashi & Takehiro Suzuki & Yuriko Osakabe & Shigeyuki Betsuyaku & Yuki Kondo & Naoshi Dohmae & Hiroo Fukuda & Kazuko Yamaguchi-Shinozaki & Kazuo Shinozaki - 239-243 Advanced maturation of human cardiac tissue grown from pluripotent stem cells
by Kacey Ronaldson-Bouchard & Stephen P. Ma & Keith Yeager & Timothy Chen & LouJin Song & Dario Sirabella & Kumi Morikawa & Diogo Teles & Masayuki Yazawa & Gordana Vunjak-Novakovic - 244-248 Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury
by Shengda Lin & Elisabete M. Nascimento & Chandresh R. Gajera & Lu Chen & Patrick Neuhöfer & Alina Garbuzov & Sui Wang & Steven E. Artandi - 249-254 Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
by Subhamoy Dasgupta & Kimal Rajapakshe & Bokai Zhu & Bryan C. Nikolai & Ping Yi & Nagireddy Putluri & Jong Min Choi & Sung Y. Jung & Cristian Coarfa & Thomas F. Westbrook & Xiang H.-F. Zhang & Charles E. Foulds & Sophia Y. Tsai & Ming-Jer Tsai & Bert W. O’Malley - 255-258 Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
by Peng Zhou & Hang Fan & Tian Lan & Xing-Lou Yang & Wei-Feng Shi & Wei Zhang & Yan Zhu & Ya-Wei Zhang & Qing-Mei Xie & Shailendra Mani & Xiao-Shuang Zheng & Bei Li & Jin-Man Li & Hua Guo & Guang-Qian Pei & Xiao-Ping An & Jun-Wei Chen & Ling Zhou & Kai-Jie Mai & Zi-Xian Wu & Di Li & Danielle E. Anderson & Li-Biao Zhang & Shi-Yue Li & Zhi-Qiang Mi & Tong-Tong He & Feng Cong & Peng-Ju Guo & Ren Huang & Yun Luo & Xiang-Ling Liu & Jing Chen & Yong Huang & Qiang Sun & Xiang-Li-Lan Zhang & Yuan-Yuan Wang & Shao-Zhen Xing & Yan-Shan Chen & Yuan Sun & Juan Li & Peter Daszak & Lin-Fa Wang & Zheng-Li Shi & Yi-Gang Tong & Jing-Yun Ma - 259-261 Cancer research with a human touch
by Mike May - 263-265 Outsourcing is in
by Esther Landhuis - 265-265 Convert your weaknesses into assets
by Lia Paola Zambetti - 268-268 e-PLURIBUS
by S. R. Algernon
April 2018, Volume 556, Issue 7699
- 1-2 Improving outcomes in congenital cataract
by Ameenat Lola Solebo & Christopher J. Hammond & Jugnoo S. Rahi - 2-3 Lens regeneration in children
by Demetrios G. Vavvas & Thaddeus P. Dryja & M. Edward Wilson & Timothy W. Olsen & Ankoor Shah & Ula Jurkunas & Roberto Pineda & Vasiliki Poulaki & Sotiria Palioura & Peter Veldman & Javier Moreno-Montañés & Maria D. Pinazo-Duran & José Carlos Pastor & Miltiadis Tsilimbaris & Douglas Rhee & Kathryn Colby & David G. Hunter & Solon Thanos & Taiji Sakamoto & Louis R. Pasquale & Joan W. Miller & Deborah VanderVeen & Scott R. Lambert - 3-4 Liu et al. reply
by Yizhi Liu & David Granet & Haotian Lin & Sally Baxter & Hong Ouyang & Jie Zhu & Shan Huang & Zhenzhen Liu & Xiaokang Wu & Fangbing Yan & Xialin Liu & Lixia Luo & Christopher Heichel & Meixia Zhang & Wenjia Cai & Richard L. Maas & Kang Zhang - 5-7 Investigating non-Joulian magnetostriction
by Yangkun He & Yongjun Han & P. Stamenov & B. Kundys & J. M. D. Coey & Chengbao Jiang & Huibin Xu - 7-7 Use our personal data for the common good
by Hetan Shah - 11-12 NASA reveals major delay for $8-billion Hubble successor
by Alexandra Witze