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Finding the missing heritability of complex diseases

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Cited by:

  1. Celine A. Manigbas & Bharati Jadhav & Paras Garg & Mariya Shadrina & William Lee & Gabrielle Altman & Alejandro Martin-Trujillo & Andrew J. Sharp, 2024. "A phenome-wide association study of tandem repeat variation in 168,554 individuals from the UK Biobank," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
  2. Lin Yuan & Chang-An Yuan & De-Shuang Huang, 2017. "FAACOSE: A Fast Adaptive Ant Colony Optimization Algorithm for Detecting SNP Epistasis," Complexity, Hindawi, vol. 2017, pages 1-10, September.
  3. Young Lee & Suyeon Park & Sanghoon Moon & Juyoung Lee & Robert C. Elston & Woojoo Lee & Sungho Won, 2014. "On the Analysis of a Repeated Measure Design in Genome-Wide Association Analysis," IJERPH, MDPI, vol. 11(12), pages 1-21, November.
  4. Bar Haim Y. & Booth James G. & Wells Martin T., 2012. "A Mixture-Model Approach for Parallel Testing for Unequal Variances," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 11(1), pages 1-21, January.
  5. Gaëlle Marenne & Stephen J Chanock & Núria Malats & Emmanuelle Génin, 2013. "Advantage of Using Allele-Specific Copy Numbers When Testing for Association in Regions with Common Copy Number Variants," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
  6. Ai-Ru Hsieh & Dao-Peng Chen & Amrita Sengupta Chattopadhyay & Ying-Ju Li & Chien-Ching Chang & Cathy S J Fann, 2017. "A non-threshold region-specific method for detecting rare variants in complex diseases," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-16, November.
  7. Chang Lu & Jan Zaucha & Rihab Gam & Hai Fang & Smithers & Matt E. Oates & Miguel Bernabe-Rubio & James Williams & Natalie Zelenka & Arun Prasad Pandurangan & Himani Tandon & Hashem Shihab & Raju Kalai, 2023. "Hypothesis-free phenotype prediction within a genetics-first framework," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
  8. Noha Sharafeldin & Martha L. Slattery & Qi Liu & Conrado Franco-Villalobos & Bette J. Caan & John D. Potter & Yutaka Yasui, 2017. "Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival," IJERPH, MDPI, vol. 14(10), pages 1-15, September.
  9. Kevin R Thornton & Andrew J Foran & Anthony D Long, 2013. "Properties and Modeling of GWAS when Complex Disease Risk Is Due to Non-Complementing, Deleterious Mutations in Genes of Large Effect," PLOS Genetics, Public Library of Science, vol. 9(2), pages 1-14, February.
  10. Lorena Alonso & Ignasi Morán & Cecilia Salvoro & David Torrents, 2021. "In Search of Complex Disease Risk through Genome Wide Association Studies," Mathematics, MDPI, vol. 9(23), pages 1-26, November.
  11. Ilias Georgakopoulos-Soares & Chengyu Deng & Vikram Agarwal & Candace S. Y. Chan & Jingjing Zhao & Fumitaka Inoue & Nadav Ahituv, 2023. "Transcription factor binding site orientation and order are major drivers of gene regulatory activity," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
  12. Ian Barnett & Rajarshi Mukherjee & Xihong Lin, 2017. "The Generalized Higher Criticism for Testing SNP-Set Effects in Genetic Association Studies," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 112(517), pages 64-76, January.
  13. Yoshitaka Nagamine & Ricardo Pong-Wong & Pau Navarro & Veronique Vitart & Caroline Hayward & Igor Rudan & Harry Campbell & James Wilson & Sarah Wild & Andrew A Hicks & Peter P Pramstaller & Nicholas H, 2012. "Localising Loci underlying Complex Trait Variation Using Regional Genomic Relationship Mapping," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-12, October.
  14. Andrew K MacLeod & Gail Davies & Antony Payton & Albert Tenesa & Sarah E Harris & David Liewald & Xiayi Ke & Michelle Luciano & Lorna M Lopez & Alan J Gow & Janie Corley & Paul Redmond & Geraldine McN, 2012. "Genetic Copy Number Variation and General Cognitive Ability," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-9, December.
  15. Lucas Alvizi & Diogo Nani & Luciano Abreu Brito & Gerson Shigeru Kobayashi & Maria Rita Passos-Bueno & Roberto Mayor, 2023. "Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene–environment interaction," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
  16. Noah Zaitlen & Peter Kraft & Nick Patterson & Bogdan Pasaniuc & Gaurav Bhatia & Samuela Pollack & Alkes L Price, 2013. "Using Extended Genealogy to Estimate Components of Heritability for 23 Quantitative and Dichotomous Traits," PLOS Genetics, Public Library of Science, vol. 9(5), pages 1-11, May.
  17. Ruixue Fan & Shaw-Hwa Lo, 2013. "A Robust Model-free Approach for Rare Variants Association Studies Incorporating Gene-Gene and Gene-Environmental Interactions," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-14, December.
  18. Colin D Steer & Patrick Bolton & Jean Golding, 2015. "Preconception and Prenatal Environmental Factors Associated with Communication Impairments in 9 Year Old Children Using an Exposome-Wide Approach," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-26, March.
  19. Dongjun Chung & Can Yang & Cong Li & Joel Gelernter & Hongyu Zhao, 2014. "GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation," PLOS Genetics, Public Library of Science, vol. 10(11), pages 1-14, November.
  20. Silviu-Alin Bacanu & Matthew R Nelson & John C Whittaker, 2012. "Comparison of Statistical Tests for Association between Rare Variants and Binary Traits," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-7, August.
  21. Zhuoran Xu & Quan Li & Luigi Marchionni & Kai Wang, 2023. "PhenoSV: interpretable phenotype-aware model for the prioritization of genes affected by structural variants," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
  22. Jennifer A. Smith & Wei Zhao & Kalyn Yasutake & Carmella August & Scott M. Ratliff & Jessica D. Faul & Eric Boerwinkle & Aravinda Chakravarti & Ana V. Diez Roux & Yan Gao & Michael E. Griswold & Gerar, 2017. "Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies," IJERPH, MDPI, vol. 14(12), pages 1-18, December.
  23. Oxley, Florence A.R. & Wilding, Kirsty & von Stumm, Sophie, 2024. "DNA and IQ: Big deal or much ado about nothing? – A meta-analysis," Intelligence, Elsevier, vol. 107(C).
  24. Hans Fredrik Sunde & Nikolai Haahjem Eftedal & Rosa Cheesman & Elizabeth C. Corfield & Thomas H. Kleppesto & Anne Caroline Seierstad & Eivind Ystrom & Espen Moen Eilertsen & Fartein Ask Torvik, 2024. "Genetic similarity between relatives provides evidence on the presence and history of assortative mating," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
  25. Denny Borsboom & Angélique O J Cramer & Verena D Schmittmann & Sacha Epskamp & Lourens J Waldorp, 2011. "The Small World of Psychopathology," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-11, November.
  26. Gustavo de los Campos & Ana I Vazquez & Rohan Fernando & Yann C Klimentidis & Daniel Sorensen, 2013. "Prediction of Complex Human Traits Using the Genomic Best Linear Unbiased Predictor," PLOS Genetics, Public Library of Science, vol. 9(7), pages 1-15, July.
  27. Guo, Fangqi & Harris, Kathleen Mullan & Boardman, Jason D. & Robinette, Jennifer W., 2022. "Does crime trigger genetic risk for type 2 diabetes in young adults? A G x E interaction study using national data," Social Science & Medicine, Elsevier, vol. 313(C).
  28. Diana Chang & Alon Keinan, 2012. "Predicting Signatures of “Synthetic Associations” and “Natural Associations” from Empirical Patterns of Human Genetic Variation," PLOS Computational Biology, Public Library of Science, vol. 8(7), pages 1-9, July.
  29. Bingxin Zhao & Fei Zou, 2022. "On polygenic risk scores for complex traits prediction," Biometrics, The International Biometric Society, vol. 78(2), pages 499-511, June.
  30. von Stumm, Sophie & Kandaswamy, Radhika & Maxwell, Jessye, 2023. "Gene-environment interplay in early life cognitive development," Intelligence, Elsevier, vol. 98(C).
  31. Surina Singh & Ananyo Choudhury & Scott Hazelhurst & Nigel J. Crowther & Palwendé R. Boua & Hermann Sorgho & Godfred Agongo & Engelbert A. Nonterah & Lisa K. Micklesfield & Shane A. Norris & Isaac Kis, 2023. "Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
  32. Gaurav Bhatia & Vikas Bansal & Olivier Harismendy & Nicholas J Schork & Eric J Topol & Kelly Frazer & Vineet Bafna, 2010. "A Covering Method for Detecting Genetic Associations between Rare Variants and Common Phenotypes," PLOS Computational Biology, Public Library of Science, vol. 6(10), pages 1-12, October.
  33. Ting Fu & Kofi Amoah & Tracey W. Chan & Jae Hoon Bahn & Jae-Hyung Lee & Sari Terrazas & Rockie Chong & Sriram Kosuri & Xinshu Xiao, 2024. "Massively parallel screen uncovers many rare 3′ UTR variants regulating mRNA abundance of cancer driver genes," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
  34. Andrea R. Waksmunski & Yeunjoo E. Song & Tyler G. Kinzy & Reneé A. Laux & Jane Sewell & Denise Fuzzell & Sarada Fuzzell & Sherri Miller & Janey L. Wiggs & Louis R. Pasquale & Jonathan M. Skarie & Jona, 2021. "The GGLEAM Study: Understanding Glaucoma in the Ohio Amish," IJERPH, MDPI, vol. 18(4), pages 1-13, February.
  35. Zheng Xu & Song Yan & Shuai Yuan & Cong Wu & Sixia Chen & Zifang Guo & Yun Li, 2023. "Efficient Two-Stage Analysis for Complex Trait Association with Arbitrary Depth Sequencing Data," Stats, MDPI, vol. 6(1), pages 1-14, March.
  36. Zhongshang Yuan & Hong Liu & Xiaoshuai Zhang & Fangyu Li & Jinghua Zhao & Furen Zhang & Fuzhong Xue, 2013. "From Interaction to Co-Association —A Fisher r-To-z Transformation-Based Simple Statistic for Real World Genome-Wide Association Study," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-8, July.
  37. Margaret Sunitha Selvaraj & Xihao Li & Zilin Li & Akhil Pampana & David Y. Zhang & Joseph Park & Stella Aslibekyan & Joshua C. Bis & Jennifer A. Brody & Brian E. Cade & Lee-Ming Chuang & Ren-Hua Chung, 2022. "Whole genome sequence analysis of blood lipid levels in >66,000 individuals," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
  38. Remo Monti & Pia Rautenstrauch & Mahsa Ghanbari & Alva Rani James & Matthias Kirchler & Uwe Ohler & Stefan Konigorski & Christoph Lippert, 2022. "Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
  39. C Ryan King & Paul J Rathouz & Dan L Nicolae, 2010. "An Evolutionary Framework for Association Testing in Resequencing Studies," PLOS Genetics, Public Library of Science, vol. 6(11), pages 1-11, November.
  40. Jayshree Advani & Puja A. Mehta & Andrew R. Hamel & Sudeep Mehrotra & Christina Kiel & Tobias Strunz & Ximena Corso-Díaz & Madeline Kwicklis & Freekje Asten & Rinki Ratnapriya & Emily Y. Chew & Dena G, 2024. "QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
  41. Agnieszka Boroń & Małgorzata Śmiarowska & Anna Grzywacz & Krzysztof Chmielowiec & Jolanta Chmielowiec & Jolanta Masiak & Tomasz Pawłowski & Dariusz Larysz & Andrzej Ciechanowicz, 2022. "Association of Polymorphism within the Putative miRNA Target Site in the 3′UTR Region of the DRD2 Gene with Neuroticism in Patients with Substance Use Disorder," IJERPH, MDPI, vol. 19(16), pages 1-21, August.
  42. Sven Stringer & Eske M Derks & René S Kahn & William G Hill & Naomi R Wray, 2013. "Assumptions and Properties of Limiting Pathway Models for Analysis of Epistasis in Complex Traits," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-9, July.
  43. Jaleal S Sanjak & Anthony D Long & Kevin R Thornton, 2017. "A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets," PLOS Genetics, Public Library of Science, vol. 13(1), pages 1-30, January.
  44. Sahir R Bhatnagar & Yi Yang & Tianyuan Lu & Erwin Schurr & JC Loredo-Osti & Marie Forest & Karim Oualkacha & Celia M T Greenwood, 2020. "Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models," PLOS Genetics, Public Library of Science, vol. 16(5), pages 1-25, May.
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