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Genetic Copy Number Variation and General Cognitive Ability

Author

Listed:
  • Andrew K MacLeod
  • Gail Davies
  • Antony Payton
  • Albert Tenesa
  • Sarah E Harris
  • David Liewald
  • Xiayi Ke
  • Michelle Luciano
  • Lorna M Lopez
  • Alan J Gow
  • Janie Corley
  • Paul Redmond
  • Geraldine McNeill
  • Andrew Pickles
  • William Ollier
  • Michael Horan
  • John M Starr
  • Neil Pendleton
  • Pippa A Thomson
  • David J Porteous
  • Ian J Deary

Abstract

Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (≥500kb), rare (

Suggested Citation

  • Andrew K MacLeod & Gail Davies & Antony Payton & Albert Tenesa & Sarah E Harris & David Liewald & Xiayi Ke & Michelle Luciano & Lorna M Lopez & Alan J Gow & Janie Corley & Paul Redmond & Geraldine McN, 2012. "Genetic Copy Number Variation and General Cognitive Ability," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-9, December.
    • Handle: RePEc:plo:pone00:0037385
    DOI: 10.1371/journal.pone.0037385
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