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Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study

Author

Listed:
  • Surina Singh

    (University of the Witwatersrand
    University of the Witwatersrand)

  • Ananyo Choudhury

    (University of the Witwatersrand)

  • Scott Hazelhurst

    (University of the Witwatersrand
    University of the Witwatersrand)

  • Nigel J. Crowther

    (University of the Witwatersrand)

  • Palwendé R. Boua

    (University of the Witwatersrand
    Institut de Recherche en Sciences de la Sante)

  • Hermann Sorgho

    (Institut de Recherche en Sciences de la Sante)

  • Godfred Agongo

    (C.K. Tedam University of Technology and Applied Sciences
    Ghana Health Service)

  • Engelbert A. Nonterah

    (Ghana Health Service
    University Medical Centre Utrecht)

  • Lisa K. Micklesfield

    (University of the Witwatersrand)

  • Shane A. Norris

    (University of the Witwatersrand
    University of Southampton)

  • Isaac Kisiangani

    (African Population and Health Research Center)

  • Shukri Mohamed

    (African Population and Health Research Center)

  • Francesc X. Gómez-Olivé

    (University of the Witwatersrand)

  • Stephen M. Tollman

    (University of the Witwatersrand)

  • Solomon Choma

    (University of Limpopo)

  • J-T. Brandenburg

    (University of the Witwatersrand
    University of the Witwatersrand)

  • Michèle Ramsay

    (University of the Witwatersrand
    University of the Witwatersrand)

Abstract

Most hypertension-related genome-wide association studies (GWASs) focus on non-African populations, despite hypertension (a major risk factor for cardiovascular disease) being highly prevalent in Africa. The AWI-Gen study GWAS meta-analysis for blood pressure (BP)-related traits (systolic and diastolic BP, pulse pressure, mean-arterial pressure and hypertension) from three sub-Saharan African geographic regions (N = 10,775), identifies two novel genome-wide significant signals (p

Suggested Citation

  • Surina Singh & Ananyo Choudhury & Scott Hazelhurst & Nigel J. Crowther & Palwendé R. Boua & Hermann Sorgho & Godfred Agongo & Engelbert A. Nonterah & Lisa K. Micklesfield & Shane A. Norris & Isaac Kis, 2023. "Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-44079-0
    DOI: 10.1038/s41467-023-44079-0
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    References listed on IDEAS

    as
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