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The GGLEAM Study: Understanding Glaucoma in the Ohio Amish

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Listed:
  • Andrea R. Waksmunski

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Yeunjoo E. Song

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Tyler G. Kinzy

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Reneé A. Laux

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Jane Sewell

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Denise Fuzzell

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Sarada Fuzzell

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Sherri Miller

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Janey L. Wiggs

    (Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA)

  • Louis R. Pasquale

    (Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Jonathan M. Skarie

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Ohio Eye Associates, Mansfield, OH 44906, USA)

  • Jonathan L. Haines

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA)

  • Jessica N. Cooke Bailey

    (Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA)

Abstract

Glaucoma leads to millions of cases of visual impairment and blindness around the world. Its susceptibility is shaped by both environmental and genetic risk factors. Although over 120 risk loci have been identified for glaucoma, a large portion of its heritability is still unexplained. Here we describe the foundation of the Genetics of GLaucoma Evaluation in the AMish (GGLEAM) study to investigate the genetic architecture of glaucoma in the Ohio Amish, which exhibits lower genetic and environmental heterogeneity compared to the general population. To date, we have enrolled 81 Amish individuals in our study from Holmes County, Ohio. As a part of our enrollment process, 62 GGLEAM study participants (42 glaucoma-affected and 20 unaffected individuals) received comprehensive eye examinations and glaucoma evaluations. Using the data from the Anabaptist Genealogy Database, we found that 80 of the GGLEAM study participants were related to one another through a large, multigenerational pedigree containing 1586 people. We plan to integrate the health and kinship data obtained for the GGLEAM study to interrogate glaucoma genetics and pathophysiology in this unique population.

Suggested Citation

  • Andrea R. Waksmunski & Yeunjoo E. Song & Tyler G. Kinzy & Reneé A. Laux & Jane Sewell & Denise Fuzzell & Sarada Fuzzell & Sherri Miller & Janey L. Wiggs & Louis R. Pasquale & Jonathan M. Skarie & Jona, 2021. "The GGLEAM Study: Understanding Glaucoma in the Ohio Amish," IJERPH, MDPI, vol. 18(4), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1551-:d:494592
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    References listed on IDEAS

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    1. Teri A. Manolio & Francis S. Collins & Nancy J. Cox & David B. Goldstein & Lucia A. Hindorff & David J. Hunter & Mark I. McCarthy & Erin M. Ramos & Lon R. Cardon & Aravinda Chakravarti & Judy H. Cho &, 2009. "Finding the missing heritability of complex diseases," Nature, Nature, vol. 461(7265), pages 747-753, October.
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