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Gene-environment interplay in early life cognitive development

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  • von Stumm, Sophie
  • Kandaswamy, Radhika
  • Maxwell, Jessye

Abstract

Children's differences in early life cognitive development are driven by the interplay of genetic and environmental factors, but identifying replicable gene-environment interactions (GxE) has proven difficult. We systematically tested GxE effects in the prediction of cognitive development from 2 to 4 years, using polygenic scores (PGS) for years spent in education and 39 measures of the home and neighborhood environment. Data came from up to 6973 unrelated individuals from the Twins Early Development Study (TEDS), a UK population-representative cohort. The environmental measures accounted together for 20.6% of the variance in cognitive development, while the PGS accounted for 0.5% (p < .001). We observed substantial gene-environment correlations but found no conclusive evidence for GxE effects. While associations between PGS and cognitive development were weak, genetic and environmental factors had direct and additive (i.e., main effects) rather than interactive influences on early life cognitive development.

Suggested Citation

  • von Stumm, Sophie & Kandaswamy, Radhika & Maxwell, Jessye, 2023. "Gene-environment interplay in early life cognitive development," Intelligence, Elsevier, vol. 98(C).
    • Handle: RePEc:eee:intell:v:98:y:2023:i:c:s0160289623000296
    DOI: 10.1016/j.intell.2023.101748
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    1. Victor Ronda & Esben Agerbo & Dorthe Bleses & Preben Bo Mortensen & Anders Børglum & Ole Mors & Michael Rosholm & David M. Hougaard & Merete Nordentoft & Thomas Werge, 2022. "Family disadvantage, gender, and the returns to genetic human capital," Scandinavian Journal of Economics, Wiley Blackwell, vol. 124(2), pages 550-578, April.
    2. Abdel Abdellaoui & David Hugh-Jones & Loic Yengo & Kathryn E. Kemper & Michel G. Nivard & Laura Veul & Yan Holtz & Brendan P. Zietsch & Timothy M. Frayling & Naomi R. Wray & Jian Yang & Karin J. H. Ve, 2019. "Genetic correlates of social stratification in Great Britain," Nature Human Behaviour, Nature, vol. 3(12), pages 1332-1342, December.
    3. Rosseel, Yves, 2012. "lavaan: An R Package for Structural Equation Modeling," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 48(i02).
    4. Ken B Hanscombe & Maciej Trzaskowski & Claire M A Haworth & Oliver S P Davis & Philip S Dale & Robert Plomin, 2012. "Socioeconomic Status (SES) and Children's Intelligence (IQ): In a UK-Representative Sample SES Moderates the Environmental, Not Genetic, Effect on IQ," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-16, February.
    5. Andrea G Allegrini & Ville Karhunen & Jonathan R I Coleman & Saskia Selzam & Kaili Rimfeld & Sophie von Stumm & Jean-Baptiste Pingault & Robert Plomin, 2020. "Multivariable G-E interplay in the prediction of educational achievement," PLOS Genetics, Public Library of Science, vol. 16(11), pages 1-20, November.
    6. Brendan Maher, 2008. "Personal genomes: The case of the missing heritability," Nature, Nature, vol. 456(7218), pages 18-21, November.
    7. Teri A. Manolio & Francis S. Collins & Nancy J. Cox & David B. Goldstein & Lucia A. Hindorff & David J. Hunter & Mark I. McCarthy & Erin M. Ramos & Lon R. Cardon & Aravinda Chakravarti & Judy H. Cho &, 2009. "Finding the missing heritability of complex diseases," Nature, Nature, vol. 461(7265), pages 747-753, October.
    8. repec:bla:econom:v:70:y:2003:i:277:p:73-97 is not listed on IDEAS
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    1. von Stumm, Sophie & Nancarrow, Allie F., 2024. "New methods, persistent issues, and one solution: Gene-environment interaction studies of childhood cognitive development," Intelligence, Elsevier, vol. 105(C).

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