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Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy

Author

Listed:
  • Yang Yang

    (South China Normal University)

  • Jinshu Huang

    (South China University of Technology)

  • Wei Wei

    (South China Normal University)

  • Qin Zeng

    (South China Normal University)

  • Xipeng Li

    (South China Normal University)

  • Da Xing

    (South China Normal University)

  • Bo Zhou

    (South China University of Technology)

  • Tao Zhang

    (South China Normal University
    South China Normal University)

Abstract

Phototheranostics based on upconversion nanoparticles (UCNPs) offer the integration of imaging diagnostics and phototherapeutics. However, the programmable control of the photoactivation of imaging and therapy with minimum side effects is challenging due to the lack of ideal switchable UCNPs agents. Here we demonstrate a facile strategy to switch the near infrared emission at 800 nm from rationally designed UCNPs by modulating the irradiation laser into pulse output. We further synthesize a theranostic nanoagent by combining with a photosensitizer and a photoabsorbing agent assembled on the UCNPs. The orthogonal activation of in vivo photoacoustic imaging and photodynamic therapy can be achieved by altering the excitation modes from pulse to continuous-wave output upon a single 980 nm laser. No obvious harmful effects during photoexcitation was identified, suggesting their use for long-term imaging-guidance and phototherapy. This work provides an approach to the orthogonal activation of imaging diagnostics and photodynamic therapeutics.

Suggested Citation

  • Yang Yang & Jinshu Huang & Wei Wei & Qin Zeng & Xipeng Li & Da Xing & Bo Zhou & Tao Zhang, 2022. "Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30713-w
    DOI: 10.1038/s41467-022-30713-w
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    References listed on IDEAS

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    Cited by:

    1. Long Yan & Jinshu Huang & Zhengce An & Qinyuan Zhang & Bo Zhou, 2024. "Spatiotemporal control of photochromic upconversion through interfacial energy transfer," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Kaiyuan Wang & Yang Li & Xia Wang & Zhijun Zhang & Liping Cao & Xiaoyuan Fan & Bin Wan & Fengxiang Liu & Xuanbo Zhang & Zhonggui He & Yingtang Zhou & Dong Wang & Jin Sun & Xiaoyuan Chen, 2023. "Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Liang Zhang & An Song & Qi-Chao Yang & Shu-Jin Li & Shuo Wang & Shu-Cheng Wan & Jianwei Sun & Ryan T. K. Kwok & Jacky W. Y. Lam & Hexiang Deng & Ben Zhong Tang & Zhi-Jun Sun, 2023. "Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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