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Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature

Author

Listed:
  • Xingjun Zhu

    (Institutes of Biomedical Sciences, Fudan University)

  • Wei Feng

    (State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Jian Chang

    (Fudan University)

  • Yan-Wen Tan

    (Fudan University)

  • Jiachang Li

    (State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Min Chen

    (State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Yun Sun

    (State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Fuyou Li

    (Institutes of Biomedical Sciences, Fudan University
    State Key Laboratory of Molecular Engineering of Polymers, Fudan University
    Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University)

Abstract

Photothermal therapy (PTT) at present, following the temperature definition for conventional thermal therapy, usually keeps the temperature of lesions at 42–45 °C or even higher. Such high temperature kills cancer cells but also increases the damage of normal tissues near lesions through heat conduction and thus brings about more side effects and inhibits therapeutic accuracy. Here we use temperature-feedback upconversion nanoparticle combined with photothermal material for real-time monitoring of microscopic temperature in PTT. We observe that microscopic temperature of photothermal material upon illumination is high enough to kill cancer cells when the temperature of lesions is still low enough to prevent damage to normal tissue. On the basis of the above phenomenon, we further realize high spatial resolution photothermal ablation of labelled tumour with minimal damage to normal tissues in vivo. Our work points to a method for investigating photothermal properties at nanoscale, and for the development of new generation of PTT strategy.

Suggested Citation

  • Xingjun Zhu & Wei Feng & Jian Chang & Yan-Wen Tan & Jiachang Li & Min Chen & Yun Sun & Fuyou Li, 2016. "Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature," Nature Communications, Nature, vol. 7(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10437
    DOI: 10.1038/ncomms10437
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    Cited by:

    1. Yukai Wu & Fang Li & Yanan Wu & Hao Wang & Liangtao Gu & Jieying Zhang & Yukun Qi & Lingkai Meng & Na Kong & Yingjie Chai & Qian Hu & Zhenyu Xing & Wuwei Ren & Fuyou Li & Xingjun Zhu, 2024. "Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Yang Yang & Jinshu Huang & Wei Wei & Qin Zeng & Xipeng Li & Da Xing & Bo Zhou & Tao Zhang, 2022. "Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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