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Multispectral optoacoustic imaging of dynamic redox correlation and pathophysiological progression utilizing upconversion nanoprobes

Author

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  • Xiangzhao Ai

    (Sino-Singapore International Joint Research Institute (SSIJRI)
    Nanyang Technological University)

  • Zhimin Wang

    (Nanyang Technological University)

  • Haolun Cheong

    (Nanyang Technological University)

  • Yong Wang

    (Soochow University)

  • Ruochong Zhang

    (Nanyang Technological University)

  • Jun Lin

    (State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences)

  • Yuanjin Zheng

    (Nanyang Technological University)

  • Mingyuan Gao

    (Soochow University)

  • Bengang Xing

    (Sino-Singapore International Joint Research Institute (SSIJRI)
    Nanyang Technological University)

Abstract

Precise and differential profiling of the dynamic correlations and pathophysiological implications of multiplex biological mediators with deep penetration and highly programmed precision remain critical challenges in clinics. Here we present an innovative strategy by tailoring a powerful multispectral optoacoustic tomography (MSOT) technique with a photon-upconverting nanoprobe (UCN) for simultaneous visualization of diversely endogenous redox biomarkers with excellent spatiotemporal resolution in living conditions. Upon incorporating two specific radicals-sensitive NIR cyanine fluorophores onto UCNs surface, such nanoprobes can orthogonally respond to disparate oxidative and nitrosative stimulation, and generate spectrally opposite optoacoustic signal variations, which thus achieves compelling superiorities for reversed ratiometric tracking of multiple radicals under dual independent wavelength channels, and significantly, for precise validating of their complex dynamics and correlations with redox-mediated pathophysiological procession in vivo.

Suggested Citation

  • Xiangzhao Ai & Zhimin Wang & Haolun Cheong & Yong Wang & Ruochong Zhang & Jun Lin & Yuanjin Zheng & Mingyuan Gao & Bengang Xing, 2019. "Multispectral optoacoustic imaging of dynamic redox correlation and pathophysiological progression utilizing upconversion nanoprobes," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09001-7
    DOI: 10.1038/s41467-019-09001-7
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    Cited by:

    1. Xinyu Wang & Fangwei Ding & Tao Jia & Feng Li & Xiping Ding & Ruibin Deng & Kaifeng Lin & Yulin Yang & Wenzhi Wu & Debin Xia & Guanying Chen, 2024. "Molecular near-infrared triplet-triplet annihilation upconversion with eigen oxygen immunity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Yang Yang & Jinshu Huang & Wei Wei & Qin Zeng & Xipeng Li & Da Xing & Bo Zhou & Tao Zhang, 2022. "Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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