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Nanozyme-reinforced hydrogel as a H2O2-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis therapy

Author

Listed:
  • Yue Zhao

    (Shenzhen University
    Nanyang Technological University)

  • Shanliang Song

    (Shenzhen University)

  • Dongdong Wang

    (Nanyang Technological University)

  • He Liu

    (The Second Hospital of Jilin University, Orthopaedic Research Institute of Jilin Province)

  • Junmin Zhang

    (Shenzhen University)

  • Zuhao Li

    (The Second Hospital of Jilin University, Orthopaedic Research Institute of Jilin Province)

  • Jincheng Wang

    (The Second Hospital of Jilin University, Orthopaedic Research Institute of Jilin Province)

  • Xiangzhong Ren

    (Shenzhen University)

  • Yanli Zhao

    (Nanyang Technological University)

Abstract

Stem cell-based therapy has drawn attention for enhancing the osseointegration efficiency after joint replacement in the rheumatoid arthritis (RA). However, therapeutic efficacy of this approach is threatened by the accumulated reactive oxygen species (ROS) and poor oxygen supply. Herein, we develop a nanozyme-reinforced hydrogel for reshaping the hostile RA microenvironment and improving prosthetic interface osseointegration. The engineered hydrogel not only scavenges endogenously over-expressed ROS, but also synergistically produces dissolved oxygen. Such performance enables the hydrogel to be utilized as an injectable delivery vehicle of bone marrow-derived mesenchymal stem cells (BMSCs) to protect implanted cells from ROS and hypoxia-mediated death and osteogenic limitation. This nanozyme-reinforced hydrogel encapsulated with BMSCs can alleviate the symptoms of RA, including suppression of local inflammatory cytokines and improvement of osseointegration. This work provides a strategy for solving the long-lasting challenge of stem cell transplantation and revolutionizes conventional intervention methods for improving prosthetic interface osseointegration in RA.

Suggested Citation

  • Yue Zhao & Shanliang Song & Dongdong Wang & He Liu & Junmin Zhang & Zuhao Li & Jincheng Wang & Xiangzhong Ren & Yanli Zhao, 2022. "Nanozyme-reinforced hydrogel as a H2O2-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34481-5
    DOI: 10.1038/s41467-022-34481-5
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    References listed on IDEAS

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    1. Dongdong Wang & Huihui Wu & Soo Zeng Fiona Phua & Guangbao Yang & Wei Qi Lim & Long Gu & Cheng Qian & Haibao Wang & Zhen Guo & Hongzhong Chen & Yanli Zhao, 2020. "Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    2. Jian Zhang & Yongjun Zheng & Jimmy Lee & Jieyu Hua & Shilong Li & Ananth Panchamukhi & Jiping Yue & Xuewen Gou & Zhaofan Xia & Linyong Zhu & Xiaoyang Wu, 2021. "A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
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