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In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy

Author

Listed:
  • Shan Lei

    (Shenzhen University Health Science Center
    Shenzhen University)

  • Jing Zhang

    (Shenzhen University Health Science Center)

  • Nicholas Thomas Blum

    (Shenzhen University Health Science Center)

  • Meng Li

    (Shenzhen University Health Science Center)

  • Dong-Yang Zhang

    (Shenzhen University Health Science Center)

  • Weimin Yin

    (Shenzhen University Health Science Center)

  • Feng Zhao

    (Shenzhen University Health Science Center)

  • Jing Lin

    (Shenzhen University Health Science Center)

  • Peng Huang

    (Shenzhen University Health Science Center)

Abstract

Non-invasive visualization of dynamic molecular events in real-time via molecular imaging may enable the monitoring of cascade catalytic reactions in living systems, however effective imaging modalities and a robust catalytic reaction system are lacking. Here we utilize three-dimensional (3D) multispectral photoacoustic (PA) molecular imaging to monitor in vivo cascade catalytic therapy based on a dual enzyme-driven cyclic reaction platform. The system consists of a two-dimensional (2D) Pd-based nanozyme conjugated with glucose oxidase (GOx). The combination of nanozyme and GOx can induce the PA signal variation of endogenous molecules. Combined with the PA response of the nanozyme, we can simultaneously map the 3D PA signals of dynamic endogenous and exogenous molecules associated with the catalytic process, thus providing a real-time non-invasive visualization. We can also treat tumors under the navigation of the PA imaging. Therefore, our study demonstrates the imaging-guided potential of 3D multispectral PA imaging in feedback-looped cascade catalytic therapy.

Suggested Citation

  • Shan Lei & Jing Zhang & Nicholas Thomas Blum & Meng Li & Dong-Yang Zhang & Weimin Yin & Feng Zhao & Jing Lin & Peng Huang, 2022. "In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29082-1
    DOI: 10.1038/s41467-022-29082-1
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    2. Gang He & Yashi Li & Muhammad Rizwan Younis & Lian-Hua Fu & Ting He & Shan Lei & Jing Lin & Peng Huang, 2022. "Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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