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An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

Author

Listed:
  • Conghui Liu

    (University of Science & Technology Beijing
    Shenzhen University)

  • Yu Cao

    (University of Science & Technology Beijing)

  • Yaru Cheng

    (University of Science & Technology Beijing)

  • Dongdong Wang

    (University of Science & Technology Beijing)

  • Tailin Xu

    (University of Science & Technology Beijing)

  • Lei Su

    (University of Science & Technology Beijing)

  • Xueji Zhang

    (University of Science & Technology Beijing
    Shenzhen University)

  • Haifeng Dong

    (University of Science & Technology Beijing)

Abstract

The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage of oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H2O2) in chemodynamic therapy (CDT). Here, we report a H2O2/O2 self-supplying nanoagent, (MSNs@CaO2-ICG)@LA, which consists of manganese silicate (MSN)-supported calcium peroxide (CaO2) and indocyanine green (ICG) with further surface modification of phase-change material lauric acid (LA). Under laser irradiation, ICG simultaneously generates singlet oxygen and emits heat to melt the LA. The exposed CaO2 reacts with water to produce O2 and H2O2 for hypoxia-relieved ICG-mediated PDT and H2O2-supplying MSN-based CDT, acting as an open source strategy for ROS production. Additionally, the MSNs-induced glutathione depletion protects ROS from scavenging, termed reduce expenditure. This open source and reduce expenditure strategy is effective in inhibiting tumor growth both in vitro and in vivo, and significantly improves ROS generation efficiency from multi-level for ROS-involved cancer therapies.

Suggested Citation

  • Conghui Liu & Yu Cao & Yaru Cheng & Dongdong Wang & Tailin Xu & Lei Su & Xueji Zhang & Haifeng Dong, 2020. "An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15591-4
    DOI: 10.1038/s41467-020-15591-4
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    Cited by:

    1. Gang He & Yashi Li & Muhammad Rizwan Younis & Lian-Hua Fu & Ting He & Shan Lei & Jing Lin & Peng Huang, 2022. "Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Yang Yang & Jinshu Huang & Wei Wei & Qin Zeng & Xipeng Li & Da Xing & Bo Zhou & Tao Zhang, 2022. "Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Yan Meng & Yu-Qin Liu & Chao Wang & Yang Si & Yun-Jie Wang & Wen-Qi Xia & Tian Liu & Xu Cao & Zhi-Yan Guo & Jie-Jie Chen & Wen-Wei Li, 2024. "Nanoconfinement steers nonradical pathway transition in single atom fenton-like catalysis for improving oxidant utilization," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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