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A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging

Author

Listed:
  • Junjie Chen

    (South China University of Technology)

  • Longqi Chen

    (South China University of Technology)

  • Yinglong Wu

    (Nanyang Technological University)

  • Yichang Fang

    (South China University of Technology)

  • Fang Zeng

    (South China University of Technology)

  • Shuizhu Wu

    (South China University of Technology)

  • Yanli Zhao

    (Nanyang Technological University)

Abstract

Developing high-quality NIR-II fluorophores (emission in 1000–1700 nm) for in vivo imaging is of great significance. Benzothiadiazole-core fluorophores are an important class of NIR-II dyes, yet ongoing limitations such as aggregation-caused quenching in aqueous milieu and non-activatable response are still major obstacles for their biological applications. Here, we devise an activatable nanoprobe to address these limitations. A molecular probe named BTPE-NO2 is synthesized by linking a benzothiadiazole core with two tetraphenylene groups serving as hydrophobic molecular rotors, followed by incorporating two nitrophenyloxoacetamide units at both ends of the core as recognition moieties and fluorescence quenchers. An FDA-approved amphiphilic polymer Pluronic F127 is then employed to encapsulate the molecular BTPE-NO2 to render the nanoprobe BTPE-NO2@F127. The pathological levels of H2O2 in the disease sites cleave the nitrophenyloxoacetamide groups and activate the probe, thereby generating strong fluorescent emission (950~1200 nm) and ultrasound signal for multi-mode imaging of inflammatory diseases. The nanoprobe can therefore function as a robust tool for detecting and imaging the disease sites with NIR-II fluorescent and multispectral optoacoustic tomography (MSOT) imaging. Moreover, the three-dimensional MSOT images can be obtained for visualizing and locating the disease foci.

Suggested Citation

  • Junjie Chen & Longqi Chen & Yinglong Wu & Yichang Fang & Fang Zeng & Shuizhu Wu & Yanli Zhao, 2021. "A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27233-4
    DOI: 10.1038/s41467-021-27233-4
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    References listed on IDEAS

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    1. Yuanyuan Li & Zhaochong Cai & Shunjie Liu & Haoke Zhang & Sherman T. H. Wong & Jacky W. Y. Lam & Ryan T. K. Kwok & Jun Qian & Ben Zhong Tang, 2020. "Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    2. Alexander L. Antaris & Hao Chen & Shuo Diao & Zhuoran Ma & Zhe Zhang & Shoujun Zhu & Joy Wang & Alexander X. Lozano & Quli Fan & Leila Chew & Mark Zhu & Kai Cheng & Xuechuan Hong & Hongjie Dai & Zhen , 2017. "A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging," Nature Communications, Nature, vol. 8(1), pages 1-11, August.
    3. Li Lin & Peng Hu & Xin Tong & Shuai Na & Rui Cao & Xiaoyun Yuan & David C. Garrett & Junhui Shi & Konstantin Maslov & Lihong V. Wang, 2021. "High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    4. Janggun Jo & Chang H. Lee & Raoul Kopelman & Xueding Wang, 2017. "In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    5. Yinglong Wu & Shuailing Huang & Jun Wang & Lihe Sun & Fang Zeng & Shuizhu Wu, 2018. "Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    6. Huijing Xiang & Lingzhi Zhao & Luodan Yu & Hongzhong Chen & Chenyang Wei & Yu Chen & Yanli Zhao, 2021. "Self-assembled organic nanomedicine enables ultrastable photo-to-heat converting theranostics in the second near-infrared biowindow," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    7. Hailey J. Knox & Jamila Hedhli & Tae Wook Kim & Kian Khalili & Lawrence W. Dobrucki & Jefferson Chan, 2017. "A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
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