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A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

Author

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  • Jiechao Ge

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Minhuan Lan

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Bingjiang Zhou

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Weimin Liu

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Liang Guo

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Hui Wang

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Qingyan Jia

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Guangle Niu

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Xing Huang

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Hangyue Zhou

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Xiangmin Meng

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Pengfei Wang

    (Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences)

  • Chun-Sing Lee

    (City University of Hong Kong)

  • Wenjun Zhang

    (City University of Hong Kong)

  • Xiaodong Han

    (Institute of Microstructure and Properties of Advanced Materials, Beijing University of Technology)

Abstract

Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1O2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1O2 via a multistate sensitization process, resulting in a quantum yield of ~1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1O2 quantum yield, water dispersibility, photo- and pH-stability, and biocompatibility.

Suggested Citation

  • Jiechao Ge & Minhuan Lan & Bingjiang Zhou & Weimin Liu & Liang Guo & Hui Wang & Qingyan Jia & Guangle Niu & Xing Huang & Hangyue Zhou & Xiangmin Meng & Pengfei Wang & Chun-Sing Lee & Wenjun Zhang & Xi, 2014. "A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5596
    DOI: 10.1038/ncomms5596
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    Cited by:

    1. Kumar, Pradip & Dhand, Chetna & Dwivedi, Neeraj & Singh, Shiv & Khan, Raju & Verma, Sarika & Singh, Archana & Gupta, Manoj Kumar & Kumar, Surender & Kumar, Rajeev & Srivastava, Avanish Kumar, 2022. "Graphene quantum dots: A contemporary perspective on scope, opportunities, and sustainability," Renewable and Sustainable Energy Reviews, Elsevier, vol. 157(C).
    2. Weicheng Shen & Tingting Hu & Xueyan Liu & Jiajia Zha & Fanqi Meng & Zhikang Wu & Zhuolin Cui & Yu Yang & Hai Li & Qinghua Zhang & Lin Gu & Ruizheng Liang & Chaoliang Tan, 2022. "Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Wenhui Gao & Jiuyang He & Lei Chen & Xiangqin Meng & Yana Ma & Liangliang Cheng & Kangsheng Tu & Xingfa Gao & Cui Liu & Mingzhen Zhang & Kelong Fan & Dai-Wen Pang & Xiyun Yan, 2023. "Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Yang Yang & Jinshu Huang & Wei Wei & Qin Zeng & Xipeng Li & Da Xing & Bo Zhou & Tao Zhang, 2022. "Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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