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Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Author

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  • Dongdong Wang

    (Nanyang Technological University)

  • Huihui Wu

    (University of Science and Technology of China)

  • Soo Zeng Fiona Phua

    (Nanyang Technological University)

  • Guangbao Yang

    (Nanyang Technological University)

  • Wei Qi Lim

    (Nanyang Technological University)

  • Long Gu

    (Nanyang Technological University)

  • Cheng Qian

    (Nanyang Technological University)

  • Haibao Wang

    (Radiology Department of the First Affiliated Hospital of Anhui Medical University)

  • Zhen Guo

    (University of Science and Technology of China)

  • Hongzhong Chen

    (Nanyang Technological University)

  • Yanli Zhao

    (Nanyang Technological University
    Nanyang Technological University)

Abstract

Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O2 molecules to produce highly cytotoxic singlet oxygen (1O2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting of single-atom ruthenium as the active catalytic site anchored in a metal-organic framework Mn3[Co(CN)6]2 with encapsulated chlorin e6 (Ce6), which serves as a catalase-like nanozyme for oxygen generation. Coordination-driven self-assembly of organic linkers and metal ions in the presence of a biocompatible polymer generates a nanoscale network that adaptively encapsulates Ce6. The resulted OxgeMCC-r SAE possesses well-defined morphology, uniform size distribution and high loading capacity. When conducting the in situ O2 generation through the reaction between endogenous H2O2 and single-atom Ru species of OxgeMCC-r SAE, the hypoxia in tumor microenvironment is relieved. Our study demonstrates a promising self-assembled nanozyme with highly efficient single-atom catalytic sites for cancer treatment.

Suggested Citation

  • Dongdong Wang & Huihui Wu & Soo Zeng Fiona Phua & Guangbao Yang & Wei Qi Lim & Long Gu & Cheng Qian & Haibao Wang & Zhen Guo & Hongzhong Chen & Yanli Zhao, 2020. "Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-14199-7
    DOI: 10.1038/s41467-019-14199-7
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    Cited by:

    1. Kaiyuan Wang & Qing Hong & Caixia Zhu & Yuan Xu & Wang Li & Ying Wang & Wenhao Chen & Xiang Gu & Xinghua Chen & Yanfeng Fang & Yanfei Shen & Songqin Liu & Yuanjian Zhang, 2024. "Metal-ligand dual-site single-atom nanozyme mimicking urate oxidase with high substrates specificity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Liu-Chun Wang & Pei-Yu Chiou & Ya-Ping Hsu & Chin-Lai Lee & Chih-Hsuan Hung & Yi-Hsuan Wu & Wen-Jyun Wang & Gia-Ling Hsieh & Ying-Chi Chen & Li-Chan Chang & Wen-Pin Su & Divinah Manoharan & Min-Chiao , 2023. "Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Yingchao Chen & Tao Xiong & Qiang Peng & Jianjun Du & Wen Sun & Jiangli Fan & Xiaojun Peng, 2024. "Self-reporting photodynamic nanobody conjugate for precise and sustainable large-volume tumor treatment," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Yue Zhao & Shanliang Song & Dongdong Wang & He Liu & Junmin Zhang & Zuhao Li & Jincheng Wang & Xiangzhong Ren & Yanli Zhao, 2022. "Nanozyme-reinforced hydrogel as a H2O2-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Dongdong Wang & Jiawei Liu & Changlai Wang & Weiyun Zhang & Guangbao Yang & Yun Chen & Xiaodong Zhang & Yinglong Wu & Long Gu & Hongzhong Chen & Wei Yuan & Xiaokai Chen & Guofeng Liu & Bin Gao & Qianw, 2023. "Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Weicheng Shen & Tingting Hu & Xueyan Liu & Jiajia Zha & Fanqi Meng & Zhikang Wu & Zhuolin Cui & Yu Yang & Hai Li & Qinghua Zhang & Lin Gu & Ruizheng Liang & Chaoliang Tan, 2022. "Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    7. Jiabin Wu & Xianyu Zhu & Qun Li & Qiang Fu & Bingxue Wang & Beibei Li & Shanshan Wang & Qingchao Chang & Huandong Xiang & Chengliang Ye & Qiqiang Li & Liang Huang & Yan Liang & Dingsheng Wang & Yulian, 2024. "Enhancing radiation-resistance and peroxidase-like activity of single-atom copper nanozyme via local coordination manipulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    8. Shan Lei & Jing Zhang & Nicholas Thomas Blum & Meng Li & Dong-Yang Zhang & Weimin Yin & Feng Zhao & Jing Lin & Peng Huang, 2022. "In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    9. Gang He & Yashi Li & Muhammad Rizwan Younis & Lian-Hua Fu & Ting He & Shan Lei & Jing Lin & Peng Huang, 2022. "Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    10. Shaofang Zhang & Yonghui Li & Si Sun & Ling Liu & Xiaoyu Mu & Shuhu Liu & Menglu Jiao & Xinzhu Chen & Ke Chen & Huizhen Ma & Tuo Li & Xiaoyu Liu & Hao Wang & Jianning Zhang & Jiang Yang & Xiao-Dong Zh, 2022. "Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    11. Yang Yang & Jinshu Huang & Wei Wei & Qin Zeng & Xipeng Li & Da Xing & Bo Zhou & Tao Zhang, 2022. "Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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