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High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation

Author

Listed:
  • Li Lin

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology)

  • Peng Hu

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology)

  • Xin Tong

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology)

  • Shuai Na

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology)

  • Rui Cao

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology)

  • Xiaoyun Yuan

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology
    Tsinghua University, Haidian District)

  • David C. Garrett

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology)

  • Junhui Shi

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology
    China Artificial Intelligence Town)

  • Konstantin Maslov

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology)

  • Lihong V. Wang

    (Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology)

Abstract

Photoacoustic computed tomography (PACT) has generated increasing interest for uses in preclinical research and clinical translation. However, the imaging depth, speed, and quality of existing PACT systems have previously limited the potential applications of this technology. To overcome these issues, we developed a three-dimensional photoacoustic computed tomography (3D-PACT) system that features large imaging depth, scalable field of view with isotropic spatial resolution, high imaging speed, and superior image quality. 3D-PACT allows for multipurpose imaging to reveal detailed angiographic information in biological tissues ranging from the rodent brain to the human breast. In the rat brain, we visualize whole brain vasculatures and hemodynamics. In the human breast, an in vivo imaging depth of 4 cm is achieved by scanning the breast within a single breath hold of 10 s. Here, we introduce the 3D-PACT system to provide a unique tool for preclinical research and an appealing prototype for clinical translation.

Suggested Citation

  • Li Lin & Peng Hu & Xin Tong & Shuai Na & Rui Cao & Xiaoyun Yuan & David C. Garrett & Junhui Shi & Konstantin Maslov & Lihong V. Wang, 2021. "High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21232-1
    DOI: 10.1038/s41467-021-21232-1
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    Cited by:

    1. Shan Lei & Jing Zhang & Nicholas Thomas Blum & Meng Li & Dong-Yang Zhang & Weimin Yin & Feng Zhao & Jing Lin & Peng Huang, 2022. "In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Kristie Huda & Dylan J. Lawrence & Weylan Thompson & Sarah H. Lindsey & Carolyn L. Bayer, 2023. "In vivo noninvasive systemic myography of acute systemic vasoactivity in female pregnant mice," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Junjie Chen & Longqi Chen & Yinglong Wu & Yichang Fang & Fang Zeng & Shuizhu Wu & Yanli Zhao, 2021. "A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Yang Yang & Jinshu Huang & Wei Wei & Qin Zeng & Xipeng Li & Da Xing & Bo Zhou & Tao Zhang, 2022. "Switching the NIR upconversion of nanoparticles for the orthogonal activation of photoacoustic imaging and phototherapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Yuwen Chen & Haoyu Yang & Yan Luo & Yijun Niu & Muzhou Yu & Shanjun Deng & Xuanhao Wang & Handi Deng & Haichao Chen & Lixia Gao & Xinjian Li & Pingyong Xu & Fudong Xue & Jing Miao & Song-Hai Shi & Yi , 2024. "Photoacoustic Tomography with Temporal Encoding Reconstruction (PATTERN) for cross-modal individual analysis of the whole brain," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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