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Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy

Author

Listed:
  • Luyan Wu

    (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University)

  • Yusuke Ishigaki

    (Faculty of Science, Hokkaido University)

  • Wenhui Zeng

    (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University)

  • Takashi Harimoto

    (Faculty of Science, Hokkaido University)

  • Baoli Yin

    (State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University)

  • Yinghan Chen

    (Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University)

  • Shiyi Liao

    (State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University)

  • Yongchun Liu

    (State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University)

  • Yidan Sun

    (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University)

  • Xiaobo Zhang

    (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University)

  • Ying Liu

    (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University)

  • Yong Liang

    (Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University)

  • Pengfei Sun

    (State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications)

  • Takanori Suzuki

    (Faculty of Science, Hokkaido University)

  • Guosheng Song

    (State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University)

  • Quli Fan

    (State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications)

  • Deju Ye

    (State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University)

Abstract

Tumor response to radiotherapy or ferroptosis is closely related to hydroxyl radical (•OH) production. Noninvasive imaging of •OH fluctuation in tumors can allow early monitoring of response to therapy, but is challenging. Here, we report the optimization of a diene electrochromic material (1-Br-Et) as a •OH-responsive chromophore, and use it to develop a near-infrared ratiometric fluorescent and photoacoustic (FL/PA) bimodal probe for in vivo imaging of •OH. The probe displays a large FL ratio between 780 and 1113 nm (FL780/FL1113), but a small PA ratio between 755 and 905 nm (PA755/PA905). Oxidation of 1-Br-Et by •OH decreases the FL780/FL1113 while concurrently increasing the PA755/PA905, allowing the reliable monitoring of •OH production in tumors undergoing erastin-induced ferroptosis or radiotherapy.

Suggested Citation

  • Luyan Wu & Yusuke Ishigaki & Wenhui Zeng & Takashi Harimoto & Baoli Yin & Yinghan Chen & Shiyi Liao & Yongchun Liu & Yidan Sun & Xiaobo Zhang & Ying Liu & Yong Liang & Pengfei Sun & Takanori Suzuki & , 2021. "Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26380-y
    DOI: 10.1038/s41467-021-26380-y
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    References listed on IDEAS

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    1. Kaiyuan Ni & Guangxu Lan & Samuel S. Veroneau & Xiaopin Duan & Yang Song & Wenbin Lin, 2018. "Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    2. Janggun Jo & Chang H. Lee & Raoul Kopelman & Xueding Wang, 2017. "In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    3. Hailey J. Knox & Jamila Hedhli & Tae Wook Kim & Kian Khalili & Lawrence W. Dobrucki & Jefferson Chan, 2017. "A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    4. Liqin Xiong & Adam J. Shuhendler & Jianghong Rao, 2012. "Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging," Nature Communications, Nature, vol. 3(1), pages 1-9, January.
    5. Luyan Wu & Yusuke Ishigaki & Yuxuan Hu & Keisuke Sugimoto & Wenhui Zeng & Takashi Harimoto & Yidan Sun & Jian He & Takanori Suzuki & Xiqun Jiang & Hong-Yuan Chen & Deju Ye, 2020. "H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    6. Zijian Zhou & Hongzhang Deng & Weijing Yang & Zhantong Wang & Lisen Lin & Jeeva Munasinghe & Orit Jacobson & Yijing Liu & Longguang Tang & Qianqian Ni & Fei Kang & Yuan Liu & Gang Niu & Ruiliang Bai &, 2020. "Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
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    Cited by:

    1. Jiajun Xu & Ningning Zhu & Yijing Du & Tianyang Han & Xue Zheng & Jia Li & Shoujun Zhu, 2024. "Biomimetic NIR-II fluorescent proteins created from chemogenic protein-seeking dyes for multicolor deep-tissue bioimaging," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Muxiong Chen & Zhe Feng & Xiaoxiao Fan & Jun Sun & Weihang Geng & Tianxiang Wu & Jinghao Sheng & Jun Qian & Zhengping Xu, 2022. "Long-term monitoring of intravital biological processes using fluorescent protein-assisted NIR-II imaging," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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