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Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging

Author

Listed:
  • Yinglong Wu

    (Nanyang Technological University)

  • Lihe Sun

    (South China University of Technology)

  • Xiaokai Chen

    (Nanyang Technological University)

  • Jiawei Liu

    (Nanyang Technological University)

  • Juan Ouyang

    (South China University of Technology)

  • Xiaodong Zhang

    (Nanyang Technological University)

  • Yi Guo

    (Nanyang Technological University)

  • Yun Chen

    (Nanyang Technological University)

  • Wei Yuan

    (Nanyang Technological University)

  • Dongdong Wang

    (Nanyang Technological University)

  • Ting He

    (Nanyang Technological University)

  • Fang Zeng

    (South China University of Technology)

  • Hongzhong Chen

    (Nanyang Technological University
    Sun Yat-sen University)

  • Shuizhu Wu

    (South China University of Technology)

  • Yanli Zhao

    (Nanyang Technological University)

Abstract

Organic small-molecule contrast agents have attracted considerable attention in the field of multispectral optoacoustic imaging, but their weak optoacoustic performance resulted from relatively low extinction coefficient and poor water solubility restrains their widespread applications. Herein, we address these limitations by constructing supramolecular assemblies based on cucurbit[8]uril (CB[8]). Two dixanthene-based chromophores (DXP and DXBTZ) are synthesized as the model guest compounds, and then included in CB[8] to prepare host-guest complexes. The obtained DXP-CB[8] and DXBTZ-CB[8] display red-shifted and increased absorption as well as decreased fluorescence, thereby leading to a substantial enhancement in optoacoustic performance. Biological application potential of DXBTZ-CB[8] is investigated after co-assembly with chondroitin sulfate A (CSA). Benefiting from the excellent optoacoustic property of DXBTZ-CB[8] and the CD44-targeting feature of CSA, the formulated DXBTZ-CB[8]/CSA can effectively detect and diagnose subcutaneous tumors, orthotopic bladder tumors, lymphatic metastasis of tumors and ischemia/reperfusion-induced acute kidney injury in mouse models with multispectral optoacoustic imaging.

Suggested Citation

  • Yinglong Wu & Lihe Sun & Xiaokai Chen & Jiawei Liu & Juan Ouyang & Xiaodong Zhang & Yi Guo & Yun Chen & Wei Yuan & Dongdong Wang & Ting He & Fang Zeng & Hongzhong Chen & Shuizhu Wu & Yanli Zhao, 2023. "Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39610-2
    DOI: 10.1038/s41467-023-39610-2
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    References listed on IDEAS

    as
    1. Kyung Lock Kim & Gihyun Sung & Jaehwan Sim & James Murray & Meng Li & Ara Lee & Annadka Shrinidhi & Kyeng Min Park & Kimoon Kim, 2018. "Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    2. Yinglong Wu & Shuailing Huang & Jun Wang & Lihe Sun & Fang Zeng & Shuizhu Wu, 2018. "Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    3. Wei-Lei Zhou & Yong Chen & Qilin Yu & Haoyang Zhang & Zhi-Xue Liu & Xian-Yin Dai & Jing-Jing Li & Yu Liu, 2020. "Ultralong purely organic aqueous phosphorescence supramolecular polymer for targeted tumor cell imaging," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    4. Huijing Xiang & Lingzhi Zhao & Luodan Yu & Hongzhong Chen & Chenyang Wei & Yu Chen & Yanli Zhao, 2021. "Self-assembled organic nanomedicine enables ultrastable photo-to-heat converting theranostics in the second near-infrared biowindow," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    5. Hailey J. Knox & Jamila Hedhli & Tae Wook Kim & Kian Khalili & Lawrence W. Dobrucki & Jefferson Chan, 2017. "A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
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