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In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging

Author

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  • Janggun Jo

    (University of Michigan)

  • Chang H. Lee

    (University of Michigan)

  • Raoul Kopelman

    (University of Michigan
    University of Michigan)

  • Xueding Wang

    (University of Michigan
    University of Michigan Medical School)

Abstract

Changes of physiological pH are correlated with several pathologies, therefore the development of more effective medical pH imaging methods is of paramount importance. Here, we report on an in vivo pH mapping nanotechnology. This subsurface chemical imaging is based on tumor-targeted, pH sensing nanoprobes and multi-wavelength photoacoustic imaging (PAI). The nanotechnology consists of an optical pH indicator, SNARF-5F, 5-(and-6)-Carboxylic Acid, encapsulated into polyacrylamide nanoparticles with surface modification for tumor targeting. Facilitated by multi-wavelength PAI plus a spectral unmixing technique, the accuracy of pH measurement inside the biological environment is not susceptible to the background optical absorption of biomolecules, i.e., hemoglobins. As a result, both the pH levels and the hemodynamic properties across the entire tumor can be quantitatively evaluated with high sensitivity and high spatial resolution in in vivo cancer models. The imaging technology reported here holds the potential for both research on and clinical management of a variety of cancers.

Suggested Citation

  • Janggun Jo & Chang H. Lee & Raoul Kopelman & Xueding Wang, 2017. "In vivo quantitative imaging of tumor pH by nanosonophore assisted multispectral photoacoustic imaging," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00598-1
    DOI: 10.1038/s41467-017-00598-1
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    Cited by:

    1. Junjie Chen & Longqi Chen & Yinglong Wu & Yichang Fang & Fang Zeng & Shuizhu Wu & Yanli Zhao, 2021. "A H2O2-activatable nanoprobe for diagnosing interstitial cystitis and liver ischemia-reperfusion injury via multispectral optoacoustic tomography and NIR-II fluorescent imaging," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Luyan Wu & Yusuke Ishigaki & Wenhui Zeng & Takashi Harimoto & Baoli Yin & Yinghan Chen & Shiyi Liao & Yongchun Liu & Yidan Sun & Xiaobo Zhang & Ying Liu & Yong Liang & Pengfei Sun & Takanori Suzuki & , 2021. "Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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