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Femtomolar hydrogen sulfide detection via hybrid small-molecule nano-arrays

Author

Listed:
  • Xing Xing

    (Nanjing University
    Shanghai Polytechnic University
    Nanjing University)

  • Luyan Wu

    (Nanjing University)

  • Yuchen Zhang

    (Nanjing University)

  • Jiahao Pan

    (Nanjing University)

  • Yusuke Ishigaki

    (Hokkaido University)

  • Huaqing Xie

    (Shanghai Polytechnic University)

  • Takanori Suzuki

    (Hokkaido University)

  • Deju Ye

    (Nanjing University)

  • Jianhua Zhang

    (Simpcare (GuangZhou) Biotechnology Co. Ltd.)

  • Weihua Zhang

    (Nanjing University)

  • Zhenda Lu

    (Nanjing University
    Nanjing University
    Nanjing University)

Abstract

Early disease diagnosis hinges on the sensitive detection of signaling molecules. Among these, hydrogen sulfide (H2S) has emerged as a critical player in cardiovascular and nervous system signaling. On-chip immunoassays, particularly nanoarray-based interfacial detection, offer promising avenues for ultra-sensitive analysis due to their confined reaction volumes and precise signal localization. Beyond the DNA or protein biomolecules array, this work presents a promising hybrid small molecule nano-array for H2S detection, using the power of dual molecules: a dye for fluorescence emission and a quencher with specific H2S reactivity. Upon H2S interaction, the quenched fluorescence reignites, creating an easily detectable array of bright spots. The molecule nano-array sensor shows exceptional responses to H2S over 8 magnitudes of dynamic range from 1 fM to 0.1 μM, with a remarkable detection limit of 1 fM, just using a 10 μL solution. This H2S detection method has the potential to significantly improve bioassay platforms, and the hybrid small-molecule nano-arrays we developed could be a valuable tool for advancing signaling molecule detection.

Suggested Citation

  • Xing Xing & Luyan Wu & Yuchen Zhang & Jiahao Pan & Yusuke Ishigaki & Huaqing Xie & Takanori Suzuki & Deju Ye & Jianhua Zhang & Weihua Zhang & Zhenda Lu, 2024. "Femtomolar hydrogen sulfide detection via hybrid small-molecule nano-arrays," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-55123-y
    DOI: 10.1038/s41467-024-55123-y
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    References listed on IDEAS

    as
    1. Xing Xing & Zaiqin Man & Jie Bian & Yadong Yin & Weihua Zhang & Zhenda Lu, 2020. "High-resolution combinatorial patterning of functional nanoparticles," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    2. Luyan Wu & Yusuke Ishigaki & Yuxuan Hu & Keisuke Sugimoto & Wenhui Zeng & Takashi Harimoto & Yidan Sun & Jian He & Takanori Suzuki & Xiqun Jiang & Hong-Yuan Chen & Deju Ye, 2020. "H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    3. Nannan Ning & Jianchun Zhu & Yahui Du & Xiaolin Gao & Chuanyong Liu & Jingxin Li, 2014. "Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos," Nature Communications, Nature, vol. 5(1), pages 1-8, September.
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