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Self-immolative poly(thiocarbamate) with localized H2S signal amplification for precise cancer imaging and therapy

Author

Listed:
  • Qingyu Zong

    (South China University of Technology)

  • Jun Li

    (South China University of Technology)

  • Qing Xu

    (Guangzhou International Campus)

  • Ye Liu

    (South China University of Technology
    South China University of Technology)

  • Kewei Wang

    (Guangzhou International Campus)

  • Youyong Yuan

    (South China University of Technology
    Guangzhou International Campus
    South China University of Technology)

Abstract

Hydrogen sulfide is essential in numerous physiological and pathological processes and has emerged as a promising cancer imaging and signaling molecule and a potentially versatile therapeutic agent. However, the endogenous levels of hydrogen sulfide remain insufficient to perform its biological functions, and thus, developing novel strategies that amplify hydrogen sulfide signals at lesion sites is of increasing interest. In this work, a nanoplatform (SNP) based on hydrogen sulfide-responsive self-immolative poly(thiocarbamate) with localized hydrogen sulfide signal amplification capability is developed to encapsulate a hydrogen sulfide-responsive fluorescent probe (e.g., hemicyanine dye; p-Cy) or an anticancer prodrug (e.g., doxorubicin; p-DOX) to form a nanoprobe (SNPp-Cy) or nanomedicine (SNPp-DOX) for cancer imaging and therapy, respectively. SNPp-Cy exhibits a low detection limit for hydrogen sulfide, enabling ultrasensitive detection of small (

Suggested Citation

  • Qingyu Zong & Jun Li & Qing Xu & Ye Liu & Kewei Wang & Youyong Yuan, 2024. "Self-immolative poly(thiocarbamate) with localized H2S signal amplification for precise cancer imaging and therapy," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52006-0
    DOI: 10.1038/s41467-024-52006-0
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    References listed on IDEAS

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    1. Luyan Wu & Yusuke Ishigaki & Yuxuan Hu & Keisuke Sugimoto & Wenhui Zeng & Takashi Harimoto & Yidan Sun & Jian He & Takanori Suzuki & Xiqun Jiang & Hong-Yuan Chen & Deju Ye, 2020. "H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    2. Nannan Ning & Jianchun Zhu & Yahui Du & Xiaolin Gao & Chuanyong Liu & Jingxin Li, 2014. "Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos," Nature Communications, Nature, vol. 5(1), pages 1-8, September.
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