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H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo

Author

Listed:
  • Luyan Wu

    (Nanjing University)

  • Yusuke Ishigaki

    (Hokkaido University)

  • Yuxuan Hu

    (Nanjing University)

  • Keisuke Sugimoto

    (Hokkaido University)

  • Wenhui Zeng

    (Nanjing University)

  • Takashi Harimoto

    (Hokkaido University)

  • Yidan Sun

    (Nanjing University)

  • Jian He

    (The Affiliated Hospital of Nanjing University Medical School)

  • Takanori Suzuki

    (Hokkaido University)

  • Xiqun Jiang

    (Nanjing University)

  • Hong-Yuan Chen

    (Nanjing University)

  • Deju Ye

    (Nanjing University
    Nanjing University)

Abstract

Afterglow luminescent probes with high signal-to-background ratio show promise for in vivo imaging; however, such probes that can be selectively delivered into target sites and switch on afterglow luminescence remain limited. We optimize an organic electrochromic material and integrate it into near-infrared (NIR) photosensitizer (silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) and (poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene]) containing nanoparticles, developing an H2S-activatable NIR afterglow probe (F12+-ANP). F12+-ANP displays a fast reaction rate (1563 ± 141 M−1 s−1) and large afterglow turn-on ratio (~122-fold) toward H2S, enabling high-sensitivity and -specificity measurement of H2S concentration in bloods from healthy persons, hepatic or colorectal cancer patients. We further construct a hepatic-tumor-targeting and H2S-activatable afterglow probe (F12+-ANP-Gal) for noninvasive, real-time imaging of tiny subcutaneous HepG2 tumors (

Suggested Citation

  • Luyan Wu & Yusuke Ishigaki & Yuxuan Hu & Keisuke Sugimoto & Wenhui Zeng & Takashi Harimoto & Yidan Sun & Jian He & Takanori Suzuki & Xiqun Jiang & Hong-Yuan Chen & Deju Ye, 2020. "H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-14307-y
    DOI: 10.1038/s41467-020-14307-y
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    Cited by:

    1. Yongchao Liu & Lili Teng & Yifan Lyu & Guosheng Song & Xiao-Bing Zhang & Weihong Tan, 2022. "Ratiometric afterglow luminescent nanoplatform enables reliable quantification and molecular imaging," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Yue Jiang & Min Zhao & Jia Miao & Wan Chen & Yuan Zhang & Minqian Miao & Li Yang & Qing Li & Qingqing Miao, 2024. "Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Luyan Wu & Yusuke Ishigaki & Wenhui Zeng & Takashi Harimoto & Baoli Yin & Yinghan Chen & Shiyi Liao & Yongchun Liu & Yidan Sun & Xiaobo Zhang & Ying Liu & Yong Liang & Pengfei Sun & Takanori Suzuki & , 2021. "Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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