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A microenvironment-modulating dressing with proliferative degradants for the healing of diabetic wounds

Author

Listed:
  • Lianghui Cheng

    (Huazhong University of Science and Technology)

  • Zhiyong Zhuang

    (Huazhong University of Science and Technology)

  • Mingming Yin

    (Huazhong University of Science and Technology)

  • Yuan Lu

    (Huazhong University of Science and Technology)

  • Sujuan Liu

    (Huazhong University of Science and Technology)

  • Minle Zhan

    (Huazhong University of Science and Technology)

  • Liyuan Zhao

    (Huazhong University of Science and Technology)

  • Zhenyan He

    (Huazhong University of Science and Technology)

  • Fanling Meng

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Sidan Tian

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Liang Luo

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Diabetic wounds are usually entangled in a disorganized and self-perpetuating microenvironment and accompanied by a prolonged delay in tissue repair. Sustained and coordinated microenvironment regulation and tissue regeneration are key to the healing process of diabetic wounds, yet they continue to pose a formidable challenge. Here we report a rational double-layered dressing design based on chitosan and a degradable conjugated polymer polydiacetylene, poly(deca-4,6-diynedioic acid) (PDDA), that can meet this intricate requirement. With an alternating ene-yne backbone, PDDA degrades when reacting with various types of reactive oxygen species (ROS), and more importantly, generates proliferative succinic acid as a major degradant. Inheriting from PDDA, the developed PDDA-chitosan double layer dressing (PCD) can eliminate ROS in the microenvironment of diabetic wounds, alleviate inflammation, and downregulate gene expression of innate immune receptors. PCD degradation also triggers simultaneous release of succinic acid in a sustainable manner, enabling long-term promotion on tissue regeneration. We have validated the biocompatibility and excellent performance of PCD in expediting the wound healing on both diabetic mouse and porcine models, which underscores the significant translational potential of this microenvironment-modulating, growth-promoting wound dressing in diabetic wounds care.

Suggested Citation

  • Lianghui Cheng & Zhiyong Zhuang & Mingming Yin & Yuan Lu & Sujuan Liu & Minle Zhan & Liyuan Zhao & Zhenyan He & Fanling Meng & Sidan Tian & Liang Luo, 2024. "A microenvironment-modulating dressing with proliferative degradants for the healing of diabetic wounds," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54075-7
    DOI: 10.1038/s41467-024-54075-7
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    References listed on IDEAS

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    1. Yiyi Zhang & Sidan Tian & Liping Huang & Yanan Li & Yuan Lu & Hongyu Li & Guiping Chen & Fanling Meng & Gang L. Liu & Xiangliang Yang & Jiasheng Tu & Chunmeng Sun & Liang Luo, 2022. "Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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    4. Geoffrey C. Gurtner & Sabine Werner & Yann Barrandon & Michael T. Longaker, 2008. "Wound repair and regeneration," Nature, Nature, vol. 453(7193), pages 314-321, May.
    5. Jun Ishihara & Ako Ishihara & Kazuto Fukunaga & Koichi Sasaki & Michael J. V. White & Priscilla S. Briquez & Jeffrey A. Hubbell, 2018. "Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
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    7. Sidan Tian & Haozheng Li & Zhong Li & Huajun Tang & Mingming Yin & Yage Chen & Shun Wang & Yuting Gao & Xiangliang Yang & Fanling Meng & Joseph W. Lauher & Ping Wang & Liang Luo, 2020. "Polydiacetylene-based ultrastrong bioorthogonal Raman probes for targeted live-cell Raman imaging," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
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