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Precisely translating computed tomography diagnosis accuracy into therapeutic intervention by a carbon-iodine conjugated polymer

Author

Listed:
  • Mingming Yin

    (Huazhong University of Science and Technology)

  • Xiaoming Liu

    (Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
    Hubei Province Key Laboratory of Molecular Imaging)

  • Ziqiao Lei

    (Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
    Hubei Province Key Laboratory of Molecular Imaging)

  • Yuting Gao

    (China University of Geosciences)

  • Jiacheng Liu

    (Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
    Hubei Province Key Laboratory of Molecular Imaging)

  • Sidan Tian

    (Huazhong University of Science and Technology)

  • Zhiwen Liang

    (Union Hospital, Tongji Medical College, Huazhong University of Science and Technology)

  • Ye Wang

    (Union Hospital, Tongji Medical College, Huazhong University of Science and Technology)

  • Fanling Meng

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Liang Luo

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

X-ray computed tomography (CT) has an important role in precision medicine. However, CT contrast agents with high efficiency and the ability to translate diagnostic accuracy into therapeutic intervention are scarce. Here, poly(diiododiacetylene) (PIDA), a conjugated polymer composed of only carbon and iodine atoms, is reported as an efficient CT contrast agent to bridge CT diagnostic imaging with therapeutic intervention. PIDA has a high iodine payload (>84 wt%), and the aggregation of nanofibrous PIDA can further amplify CT intensity and has improved geometrical and positional stability in vivo. Moreover, with a conjugated backbone, PIDA is in deep blue color, making it dually visible by both CT imaging and the naked eyes. The performance of PIDA in CT-guided preoperative planning and visualization-guided surgery is validated using orthotopic xenograft rat models. In addition, PIDA excels clinical fiducial markers of imaging-guided radiotherapy in efficiency and biocompatibility, and exhibits successful guidance of robotic radiotherapy on Beagles, demonstrating clinical potential to translate CT diagnosis accuracy into therapeutic intervention for precision medicine.

Suggested Citation

  • Mingming Yin & Xiaoming Liu & Ziqiao Lei & Yuting Gao & Jiacheng Liu & Sidan Tian & Zhiwen Liang & Ye Wang & Fanling Meng & Liang Luo, 2022. "Precisely translating computed tomography diagnosis accuracy into therapeutic intervention by a carbon-iodine conjugated polymer," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30263-1
    DOI: 10.1038/s41467-022-30263-1
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    1. Sidan Tian & Haozheng Li & Zhong Li & Huajun Tang & Mingming Yin & Yage Chen & Shun Wang & Yuting Gao & Xiangliang Yang & Fanling Meng & Joseph W. Lauher & Ping Wang & Liang Luo, 2020. "Polydiacetylene-based ultrastrong bioorthogonal Raman probes for targeted live-cell Raman imaging," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
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