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Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing

Author

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  • Xiaoxue Han

    (University of Illinois at Urbana-Champaign
    Mills Breast Cancer Institute, Carle Foundation Hospital
    Beckman Institute
    Carle R. Woese Institute for Genomic Biology)

  • Chaimongkol Saengow

    (Beckman Institute
    University of Illinois at Urbana-Champaign)

  • Leah Ju

    (University of Illinois at Urbana-Champaign
    Mills Breast Cancer Institute, Carle Foundation Hospital)

  • Wen Ren

    (University of Illinois at Urbana-Champaign
    Mills Breast Cancer Institute, Carle Foundation Hospital)

  • Randy H. Ewoldt

    (Beckman Institute
    University of Illinois at Urbana-Champaign)

  • Joseph Irudayaraj

    (University of Illinois at Urbana-Champaign
    Mills Breast Cancer Institute, Carle Foundation Hospital
    Beckman Institute
    Carle R. Woese Institute for Genomic Biology)

Abstract

Wound healing is an obvious clinical concern that can be hindered by inadequate angiogenesis, inflammation, and chronic hypoxia. While exosomes derived from adipose tissue-derived stem cells have shown promise in accelerating healing by carrying therapeutic growth factors and microRNAs, intracellular cargo delivery is compromised in hypoxic tissues due to activated hypoxia-induced endocytic recycling. To address this challenge, we have developed a strategy to coat oxygen nanobubbles with exosomes and incorporate them into a polyvinyl alcohol/gelatin hybrid hydrogel. This approach not only alleviates wound hypoxia but also offers an efficient means of delivering exosome-coated nanoparticles in hypoxic conditions. The self-healing properties of the hydrogel, along with its component, gelatin, aids in hemostasis, while its crosslinking bonds facilitate hydrogen peroxide decomposition, to ameliorate wound inflammation. Here, we show the potential of this multifunctional hydrogel for enhanced healing, promoting angiogenesis, facilitating exosome delivery, mitigating hypoxia, and inhibiting inflammation in a male rat full-thickness wound model.

Suggested Citation

  • Xiaoxue Han & Chaimongkol Saengow & Leah Ju & Wen Ren & Randy H. Ewoldt & Joseph Irudayaraj, 2024. "Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47696-5
    DOI: 10.1038/s41467-024-47696-5
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    References listed on IDEAS

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    1. Geoffrey C. Gurtner & Sabine Werner & Yann Barrandon & Michael T. Longaker, 2008. "Wound repair and regeneration," Nature, Nature, vol. 453(7193), pages 314-321, May.
    2. Jeong-Yun Sun & Xuanhe Zhao & Widusha R. K. Illeperuma & Ovijit Chaudhuri & Kyu Hwan Oh & David J. Mooney & Joost J. Vlassak & Zhigang Suo, 2012. "Highly stretchable and tough hydrogels," Nature, Nature, vol. 489(7414), pages 133-136, September.
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