IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-47696-5.html
   My bibliography  Save this article

Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing

Author

Listed:
  • Xiaoxue Han

    (University of Illinois at Urbana-Champaign
    Mills Breast Cancer Institute, Carle Foundation Hospital
    Beckman Institute
    Carle R. Woese Institute for Genomic Biology)

  • Chaimongkol Saengow

    (Beckman Institute
    University of Illinois at Urbana-Champaign)

  • Leah Ju

    (University of Illinois at Urbana-Champaign
    Mills Breast Cancer Institute, Carle Foundation Hospital)

  • Wen Ren

    (University of Illinois at Urbana-Champaign
    Mills Breast Cancer Institute, Carle Foundation Hospital)

  • Randy H. Ewoldt

    (Beckman Institute
    University of Illinois at Urbana-Champaign)

  • Joseph Irudayaraj

    (University of Illinois at Urbana-Champaign
    Mills Breast Cancer Institute, Carle Foundation Hospital
    Beckman Institute
    Carle R. Woese Institute for Genomic Biology)

Abstract

Wound healing is an obvious clinical concern that can be hindered by inadequate angiogenesis, inflammation, and chronic hypoxia. While exosomes derived from adipose tissue-derived stem cells have shown promise in accelerating healing by carrying therapeutic growth factors and microRNAs, intracellular cargo delivery is compromised in hypoxic tissues due to activated hypoxia-induced endocytic recycling. To address this challenge, we have developed a strategy to coat oxygen nanobubbles with exosomes and incorporate them into a polyvinyl alcohol/gelatin hybrid hydrogel. This approach not only alleviates wound hypoxia but also offers an efficient means of delivering exosome-coated nanoparticles in hypoxic conditions. The self-healing properties of the hydrogel, along with its component, gelatin, aids in hemostasis, while its crosslinking bonds facilitate hydrogen peroxide decomposition, to ameliorate wound inflammation. Here, we show the potential of this multifunctional hydrogel for enhanced healing, promoting angiogenesis, facilitating exosome delivery, mitigating hypoxia, and inhibiting inflammation in a male rat full-thickness wound model.

Suggested Citation

  • Xiaoxue Han & Chaimongkol Saengow & Leah Ju & Wen Ren & Randy H. Ewoldt & Joseph Irudayaraj, 2024. "Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47696-5
    DOI: 10.1038/s41467-024-47696-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-47696-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-47696-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Geoffrey C. Gurtner & Sabine Werner & Yann Barrandon & Michael T. Longaker, 2008. "Wound repair and regeneration," Nature, Nature, vol. 453(7193), pages 314-321, May.
    2. Jeong-Yun Sun & Xuanhe Zhao & Widusha R. K. Illeperuma & Ovijit Chaudhuri & Kyu Hwan Oh & David J. Mooney & Joost J. Vlassak & Zhigang Suo, 2012. "Highly stretchable and tough hydrogels," Nature, Nature, vol. 489(7414), pages 133-136, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Huimin He & Xi Wei & Bin Yang & Hongzhen Liu & Mingze Sun & Yanran Li & Aixin Yan & Chuyang Y. Tang & Yuan Lin & Lizhi Xu, 2022. "Ultrastrong and multifunctional aerogels with hyperconnective network of composite polymeric nanofibers," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Aruã Clayton Da Silva & Junzhi Wang & Ivan Rusev Minev, 2022. "Electro-assisted printing of soft hydrogels via controlled electrochemical reactions," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Ruixin Zhu & Dandan Zhu & Zhen Zheng & Xinling Wang, 2024. "Tough double network hydrogels with rapid self-reinforcement and low hysteresis based on highly entangled networks," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Shiri Kuperman & Ram Efraty & Ina Arie & Arkadi Rahmanov & Marina Rahmanov Gavrielov & Matityahau Noff & Ron Fishel & Sandu Pitaru, 2020. "Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model," IJERPH, MDPI, vol. 17(13), pages 1-10, July.
    5. Sayan Chakraborty & Divyaleka Sampath & Melissa Ong Yu Lin & Matthew Bilton & Cheng-Kuang Huang & Mui Hoon Nai & Kizito Njah & Pierre-Alexis Goy & Cheng-Chun Wang & Ernesto Guccione & Chwee-Teck Lim &, 2021. "Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    6. Minho Seong & Kahyun Sun & Somi Kim & Hyukjoo Kwon & Sang-Woo Lee & Sarath Chandra Veerla & Dong Kwan Kang & Jaeil Kim & Stalin Kondaveeti & Salah M. Tawfik & Hyung Wook Park & Hoon Eui Jeong, 2024. "Multifunctional Magnetic Muscles for Soft Robotics," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    7. Bin Xue & Zoobia Bashir & Yachong Guo & Wenting Yu & Wenxu Sun & Yiran Li & Yiyang Zhang & Meng Qin & Wei Wang & Yi Cao, 2023. "Strong, tough, rapid-recovery, and fatigue-resistant hydrogels made of picot peptide fibres," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    8. S. M. Shatil Shahriar & Alec D. McCarthy & Syed Muntazir Andrabi & Yajuan Su & Navatha Shree Polavoram & Johnson V. John & Mitchell P. Matis & Wuqiang Zhu & Jingwei Xie, 2024. "Mechanically resilient hybrid aerogels containing fibers of dual-scale sizes and knotty networks for tissue regeneration," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    9. Ming Yang & Lufang Wang & Wenliang Liu & Wenlong Li & Yewei Huang & Qiaofeng Jin & Li Zhang & Yuanwen Jiang & Zhiqiang Luo, 2024. "Highly-stable, injectable, conductive hydrogel for chronic neuromodulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    10. Yonger Xue & Yuebao Zhang & Yichen Zhong & Shi Du & Xucheng Hou & Wenqing Li & Haoyuan Li & Siyu Wang & Chang Wang & Jingyue Yan & Diana D. Kang & Binbin Deng & David W. McComb & Darrell J. Irvine & R, 2024. "LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    11. Chen Xin & Zhongguo Ren & Leran Zhang & Liang Yang & Dawei Wang & Yanlei Hu & Jiawen Li & Jiaru Chu & Li Zhang & Dong Wu, 2023. "Light-triggered multi-joint microactuator fabricated by two-in-one femtosecond laser writing," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    12. David J. Lundberg & Christopher M. Brown & Eduard O. Bobylev & Nathan J. Oldenhuis & Yasmeen S. Alfaraj & Julia Zhao & Ilia Kevlishvili & Heather J. Kulik & Jeremiah A. Johnson, 2024. "Nested non-covalent interactions expand the functions of supramolecular polymer networks," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    13. Akio Nishijima & Akio Nishijima & Takahiro Fujimoto & Junko Nishijima & Akio Nishijima & Takahiro Fujimoto & Takamichi Hirata & Junko Nishijima, 2019. "A New Energy Device for Skin Activation to Acute Wound Using Cold Atmospheric Pressure Plasma- A Randomized Controlled Clinical Trial," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 21(1), pages 15494-15501, August.
    14. Xueru Xiong & Yunhua Chen & Zhenxing Wang & Huan Liu & Mengqi Le & Caihong Lin & Gang Wu & Lin Wang & Xuetao Shi & Yong-Guang Jia & Yanli Zhao, 2023. "Polymerizable rotaxane hydrogels for three-dimensional printing fabrication of wearable sensors," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    15. Guangyu Bao & Qiman Gao & Massimo Cau & Nabil Ali-Mohamad & Mitchell Strong & Shuaibing Jiang & Zhen Yang & Amin Valiei & Zhenwei Ma & Marco Amabili & Zu-Hua Gao & Luc Mongeau & Christian Kastrup & Ji, 2022. "Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    16. Dongliang Fan & Xi Yuan & Wenyu Wu & Renjie Zhu & Xin Yang & Yuxuan Liao & Yunteng Ma & Chufan Xiao & Cheng Chen & Changyue Liu & Hongqiang Wang & Peiwu Qin, 2022. "Self-shrinking soft demoulding for complex high-aspect-ratio microchannels," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    17. Feipeng Chen & Xiufeng Li & Yafeng Yu & Qingchuan Li & Haisong Lin & Lizhi Xu & Ho Cheung Shum, 2023. "Phase-separation facilitated one-step fabrication of multiscale heterogeneous two-aqueous-phase gel," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    18. Li Yang & Dan Zhang & Wenjing Li & Hongbing Lin & Chendi Ding & Qingyun Liu & Liangliang Wang & Zimu Li & Lin Mei & Hongzhong Chen & Yanli Zhao & Xiaowei Zeng, 2023. "Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    19. Zhengyu Xu & Jiajun Lu & Di Lu & Yiran Li & Hai Lei & Bin Chen & Wenfei Li & Bin Xue & Yi Cao & Wei Wang, 2024. "Rapidly damping hydrogels engineered through molecular friction," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    20. Cui, Shuang & Ahn, Chihyung & Wingert, Matthew C. & Leung, David & Cai, Shengqiang & Chen, Renkun, 2016. "Bio-inspired effective and regenerable building cooling using tough hydrogels," Applied Energy, Elsevier, vol. 168(C), pages 332-339.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47696-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.