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Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma

Author

Listed:
  • Dongya Zhang

    (Henan University)

  • Sidan Tian

    (Huazhong University of Science and Technology)

  • Yanjie Liu

    (Henan University)

  • Meng Zheng

    (Henan University)

  • Xiangliang Yang

    (Huazhong University of Science and Technology)

  • Yan Zou

    (Henan University
    Macquarie University)

  • Bingyang Shi

    (Henan University
    Macquarie University)

  • Liang Luo

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Glioblastoma multiforme (GBM) is one of the most fatal malignancies due to the existence of blood-brain barrier (BBB) and the difficulty to maintain an effective drug accumulation in deep GBM lesions. Here we present a biomimetic nanogel system that can be precisely activated by near infrared (NIR) irradiation to achieve BBB crossing and deep tumor penetration of drugs. Synthesized by crosslinking pullulan and poly(deca-4,6-diynedioic acid) (PDDA) and loaded with temozolomide and indocyanine green (ICG), the nanogels are inert to endogenous oxidative conditions but can be selectively disintegrated by ICG-generated reactive oxygen species upon NIR irradiation. Camouflaging the nanogels with apolipoprotein E peptide-decorated erythrocyte membrane further allows prolonged blood circulation and active tumor targeting. The precisely controlled NIR irradiation on tumor lesions excites ICG and deforms the cumulated nanogels to trigger burst drug release for facilitated BBB permeation and infiltration into distal tumor cells. These NIR-activatable biomimetic nanogels suppress the tumor growth in orthotopic GBM and GBM stem cells-bearing mouse models with significantly extended survival.

Suggested Citation

  • Dongya Zhang & Sidan Tian & Yanjie Liu & Meng Zheng & Xiangliang Yang & Yan Zou & Bingyang Shi & Liang Luo, 2022. "Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34462-8
    DOI: 10.1038/s41467-022-34462-8
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    References listed on IDEAS

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    1. Alessandro Zorzi & Simon J. Middendorp & Jonas Wilbs & Kaycie Deyle & Christian Heinis, 2017. "Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    2. Benhao Li & Mengyao Zhao & Lishuai Feng & Chaoran Dou & Suwan Ding & Gang Zhou & Lingfei Lu & Hongxin Zhang & Feiya Chen & Xiaomin Li & Guangfeng Li & Shichang Zhao & Chunyu Jiang & Yan Wang & Dongyua, 2020. "Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
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    Cited by:

    1. Sarun Juengpanich & Shijie Li & Taorui Yang & Tianao Xie & Jiadong Chen & Yukai Shan & Jiyoung Lee & Ziyi Lu & Tianen Chen & Bin Zhang & Jiasheng Cao & Jiahao Hu & Jicheng Yu & Yanfang Wang & Win Topa, 2023. "Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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