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Wound repair and regeneration

Author

Listed:
  • Geoffrey C. Gurtner

    (Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Sabine Werner

    (Institute of Cell Biology, Swiss Federal Institute of Technology (ETH), Schafmattstrasse 18, HPM D42)

  • Yann Barrandon

    (Centre Hospitalier Universitaire Vaudois, Chirurgie Éxperimentale, Pavillon 4
    École Polytechnique Fédérale Lausanne, School of Life Sciences/LDCS, Station 15)

  • Michael T. Longaker

    (Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

Abstract

The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.

Suggested Citation

  • Geoffrey C. Gurtner & Sabine Werner & Yann Barrandon & Michael T. Longaker, 2008. "Wound repair and regeneration," Nature, Nature, vol. 453(7193), pages 314-321, May.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7193:d:10.1038_nature07039
    DOI: 10.1038/nature07039
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    Citations

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    Cited by:

    1. Akio Nishijima & Akio Nishijima & Takahiro Fujimoto & Junko Nishijima & Akio Nishijima & Takahiro Fujimoto & Takamichi Hirata & Junko Nishijima, 2019. "A New Energy Device for Skin Activation to Acute Wound Using Cold Atmospheric Pressure Plasma- A Randomized Controlled Clinical Trial," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 21(1), pages 15494-15501, August.
    2. Du Wenqiang & Ashkan Novin & Yamin Liu & Junaid Afzal & Yasir Suhail & Shaofei Liu & Nicole R. Gavin & Jennifer R. Jorgensen & Christopher M. Morosky & Reinaldo Figueroa & Tannin A. Schmidt & Melinda , 2024. "Scar matrix drives Piezo1 mediated stromal inflammation leading to placenta accreta spectrum," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Li Yang & Dan Zhang & Wenjing Li & Hongbing Lin & Chendi Ding & Qingyun Liu & Liangliang Wang & Zimu Li & Lin Mei & Hongzhong Chen & Yanli Zhao & Xiaowei Zeng, 2023. "Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Chantal A. Ten Kate & Hilde J. H. Koese & M. Jenda Hop & André B. Rietman & René M. H. Wijnen & Marijn J. Vermeulen & Claudia M. G. Keyzer-Dekker, 2023. "Psychometric Performance of the Stony Brook Scar Evaluation Scale and SCAR-Q Questionnaire in Dutch Children after Pediatric Surgery," IJERPH, MDPI, vol. 21(1), pages 1-12, December.
    5. Yonger Xue & Yuebao Zhang & Yichen Zhong & Shi Du & Xucheng Hou & Wenqing Li & Haoyuan Li & Siyu Wang & Chang Wang & Jingyue Yan & Diana D. Kang & Binbin Deng & David W. McComb & Darrell J. Irvine & R, 2024. "LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Diana Boraschi & Dongjie Li & Yang Li & Paola Italiani, 2021. "In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials," IJERPH, MDPI, vol. 18(22), pages 1-16, November.
    7. Ishier Raote & Ann-Helen Rosendahl & Hanna-Maria Häkkinen & Carina Vibe & Ismail Küçükaylak & Mugdha Sawant & Lena Keufgens & Pia Frommelt & Kai Halwas & Katrina Broadbent & Marina Cunquero & Gustavo , 2024. "TANGO1 inhibitors reduce collagen secretion and limit tissue scarring," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    8. Shiman Zuo & Yuxin Wang & Hanjing Bao & Zehui Zhang & Nanfei Yang & Meng Jia & Qing Zhang & Ani Jian & Rong Ji & Lidan Zhang & Yan Lu & Yahong Huang & Pingping Shen, 2024. "Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    9. Shiri Kuperman & Ram Efraty & Ina Arie & Arkadi Rahmanov & Marina Rahmanov Gavrielov & Matityahau Noff & Ron Fishel & Sandu Pitaru, 2020. "Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model," IJERPH, MDPI, vol. 17(13), pages 1-10, July.
    10. Xiaoxue Han & Chaimongkol Saengow & Leah Ju & Wen Ren & Randy H. Ewoldt & Joseph Irudayaraj, 2024. "Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    11. Sayan Chakraborty & Divyaleka Sampath & Melissa Ong Yu Lin & Matthew Bilton & Cheng-Kuang Huang & Mui Hoon Nai & Kizito Njah & Pierre-Alexis Goy & Cheng-Chun Wang & Ernesto Guccione & Chwee-Teck Lim &, 2021. "Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing," Nature Communications, Nature, vol. 12(1), pages 1-18, December.

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