IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v515y2014i7527d10.1038_nature13909.html
   My bibliography  Save this article

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Author

Listed:
  • Edward T. Chouchani

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK)

  • Victoria R. Pell

    (University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK)

  • Edoardo Gaude

    (MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK)

  • Dunja Aksentijević

    (King’s College London, British Heart Foundation Centre of Research Excellence, The Rayne Institute, St Thomas’ Hospital, London SE1 7EH, UK)

  • Stephanie Y. Sundier

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Ellen L. Robb

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK)

  • Angela Logan

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK)

  • Sergiy M. Nadtochiy

    (University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA)

  • Emily N. J. Ord

    (Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK)

  • Anthony C. Smith

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK)

  • Filmon Eyassu

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK)

  • Rachel Shirley

    (Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK)

  • Chou-Hui Hu

    (University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK)

  • Anna J. Dare

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK)

  • Andrew M. James

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK)

  • Sebastian Rogatti

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK)

  • Richard C. Hartley

    (School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK)

  • Simon Eaton

    (Unit of Paediatric Surgery, UCL Institute of Child Health, London WC1N 1EH, UK)

  • Ana S. H. Costa

    (MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK)

  • Paul S. Brookes

    (University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA)

  • Sean M. Davidson

    (Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London WC1E 6HX, UK)

  • Michael R. Duchen

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Kourosh Saeb-Parsy

    (Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK)

  • Michael J. Shattock

    (King’s College London, British Heart Foundation Centre of Research Excellence, The Rayne Institute, St Thomas’ Hospital, London SE1 7EH, UK)

  • Alan J. Robinson

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK)

  • Lorraine M. Work

    (Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK)

  • Christian Frezza

    (MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK)

  • Thomas Krieg

    (University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK)

  • Michael P. Murphy

    (MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK)

Abstract

A metabolomics study on the ischaemic heart identifies succinate as a metabolite that drives the production of reactive oxygen species and contributes to ischaemia-reperfusion injury; pharmacological inhibition of succinate accumulation ameliorates ischaemia-reperfusion injury in a mouse model of heart attack and a rat model of stroke.

Suggested Citation

  • Edward T. Chouchani & Victoria R. Pell & Edoardo Gaude & Dunja Aksentijević & Stephanie Y. Sundier & Ellen L. Robb & Angela Logan & Sergiy M. Nadtochiy & Emily N. J. Ord & Anthony C. Smith & Filmon Ey, 2014. "Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS," Nature, Nature, vol. 515(7527), pages 431-435, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7527:d:10.1038_nature13909
    DOI: 10.1038/nature13909
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13909
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13909?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Maithily S. Nanadikar & Ana M. Vergel Leon & Jia Guo & Gijsbert J. Belle & Aline Jatho & Elvina S. Philip & Astrid F. Brandner & Rainer A. Böckmann & Runzhu Shi & Anke Zieseniss & Carla M. Siemssen & , 2023. "IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Masataka Kawamura & Catherine Parmentier & Samrat Ray & Sergi Clotet-Freixas & Sharon Leung & Rohan John & Laura Mazilescu & Emmanuel Nogueira & Yuki Noguchi & Toru Goto & Bhranavi Arulratnam & Sujani, 2024. "Normothermic ex vivo kidney perfusion preserves mitochondrial and graft function after warm ischemia and is further enhanced by AP39," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Pankaj Sharma & Elena Maklashina & Markus Voehler & Sona Balintova & Sarka Dvorakova & Michal Kraus & Katerina Hadrava Vanova & Zuzana Nahacka & Renata Zobalova & Stepana Boukalova & Kristyna Cunatova, 2024. "Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Joy Edwards-Hicks & Huizhong Su & Maurizio Mangolini & Kubra K. Yoneten & Jimi Wills & Giovanny Rodriguez-Blanco & Christine Young & Kevin Cho & Heather Barker & Morwenna Muir & Ania Naila Guerrieri &, 2022. "MYC sensitises cells to apoptosis by driving energetic demand," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Thomas Agius & Raffaella Emsley & Arnaud Lyon & Michael R. MacArthur & Kevin Kiesworo & Anna Faivre & Louis Stavart & Martine Lambelet & David Legouis & Sophie Seigneux & Déla Golshayan & Francois Laz, 2024. "Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Jiayi Wang & Mengke Zhao & Meina Wang & Dong Fu & Lin Kang & Yu Xu & Liming Shen & Shilin Jin & Liang Wang & Jing Liu, 2024. "Human neural stem cell-derived artificial organelles to improve oxidative phosphorylation," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    7. Xueqiang Wang & Xing Zhang & Ke Cao & Mengqi Zeng & Xuyang Fu & Adi Zheng & Feng Zhang & Feng Gao & Xuan Zou & Hao Li & Min Li & Weiqiang Lv & Jie Xu & Jiangang Long & Weijin Zang & Jinghai Chen & Fen, 2022. "Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    8. Chris G. Faulkes & Thomas R. Eykyn & Jan Lj. Miljkovic & James D. Gilbert & Rebecca L. Charles & Hiran A. Prag & Nikayla Patel & Daniel W. Hart & Michael P. Murphy & Nigel C. Bennett & Dunja Aksentije, 2024. "Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    9. John O. Onukwufor & M. Arsalan Farooqi & Anežka Vodičková & Shon A. Koren & Aksana Baldzizhar & Brandon J. Berry & Gisela Beutner & George A. Porter & Vsevolod Belousov & Alan Grossfield & Andrew P. W, 2022. "A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    10. Xiaoduo Tang & Jingyan Ren & Xin Wei & Tao Wang & Haiqiu Li & Yihan Sun & Yang Liu & Mingli Chi & Shoujun Zhu & Laijin Lu & Junhu Zhang & Bai Yang, 2023. "Exploiting synergistic effect of CO/NO gases for soft tissue transplantation using a hydrogel patch," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    11. Lianghui Cheng & Zhiyong Zhuang & Mingming Yin & Yuan Lu & Sujuan Liu & Minle Zhan & Liyuan Zhao & Zhenyan He & Fanling Meng & Sidan Tian & Liang Luo, 2024. "A microenvironment-modulating dressing with proliferative degradants for the healing of diabetic wounds," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    12. Yu Jin Chung & Zoe Hoare & Friedrich Baark & Chak Shun Yu & Jia Guo & William Fuller & Richard Southworth & Doerthe M. Katschinski & Michael P. Murphy & Thomas R. Eykyn & Michael J. Shattock, 2024. "Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:515:y:2014:i:7527:d:10.1038_nature13909. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.