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Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy

Author

Listed:
  • Li Yang

    (Sun Yat-sen University)

  • Dan Zhang

    (Sun Yat-sen University)

  • Wenjing Li

    (Sun Yat-sen University)

  • Hongbing Lin

    (Sun Yat-sen University)

  • Chendi Ding

    (Chinese Academy of Medical Sciences & Peking Union Medical College
    Nanyang Technological University)

  • Qingyun Liu

    (Sun Yat-sen University)

  • Liangliang Wang

    (Sun Yat-sen University)

  • Zimu Li

    (Sun Yat-sen University)

  • Lin Mei

    (Sun Yat-sen University
    Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Hongzhong Chen

    (Sun Yat-sen University
    Nanyang Technological University)

  • Yanli Zhao

    (Nanyang Technological University)

  • Xiaowei Zeng

    (Sun Yat-sen University)

Abstract

The treatment of diabetic wounds faces enormous challenges due to complex wound environments, such as infected biofilms, excessive inflammation, and impaired angiogenesis. The critical role of the microenvironment in the chronic diabetic wounds has not been addressed for therapeutic development. Herein, we develop a microneedle (MN) bandage functionalized with dopamine-coated hybrid nanoparticles containing selenium and chlorin e6 (SeC@PA), which is capable of the dual-directional regulation of reactive species (RS) generation, including reactive oxygen species (ROS) and reactive nitrogen species (RNS), in response to the wound microenvironment. The SeC@PA MN bandage can disrupt barriers in wound coverings for efficient SeC@PA delivery. SeC@PA not only depletes endogenous glutathione (GSH) to enhance the anti-biofilm effect of RS, but also degrades GSH in biofilms through cascade reactions to generate more lethal RS for biofilm eradication. SeC@PA acts as an RS scavenger in wound beds with low GSH levels, exerting an anti-inflammatory effect. SeC@PA also promotes the M2-phenotype polarization of macrophages, accelerating wound healing. This self-enhanced, catabolic and dynamic therapy, activated by the wound microenvironment, provides an approach for treating chronic wounds.

Suggested Citation

  • Li Yang & Dan Zhang & Wenjing Li & Hongbing Lin & Chendi Ding & Qingyun Liu & Liangliang Wang & Zimu Li & Lin Mei & Hongzhong Chen & Yanli Zhao & Xiaowei Zeng, 2023. "Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43067-8
    DOI: 10.1038/s41467-023-43067-8
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    References listed on IDEAS

    as
    1. Weijun Xiu & Ling Wan & Kaili Yang & Xiao Li & Lihui Yuwen & Heng Dong & Yongbin Mou & Dongliang Yang & Lianhui Wang, 2022. "Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Geoffrey C. Gurtner & Sabine Werner & Yann Barrandon & Michael T. Longaker, 2008. "Wound repair and regeneration," Nature, Nature, vol. 453(7193), pages 314-321, May.
    3. Guodong Li & Chung-Nga Ko & Dan Li & Chao Yang & Wanhe Wang & Guan-Jun Yang & Carmelo Di Primo & Vincent Kam Wai Wong & Yaozu Xiang & Ligen Lin & Dik-Lung Ma & Chung-Hang Leung, 2021. "A small molecule HIF-1α stabilizer that accelerates diabetic wound healing," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
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    Cited by:

    1. Ming Li & Chenxi Wang & Qiang Yu & Haoyi Chen & Yingying Ma & Li Wei & Mei X. Wu & Min Yao & Min Lu, 2024. "A wearable and stretchable dual-wavelength LED device for home care of chronic infected wounds," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Lianghui Cheng & Zhiyong Zhuang & Mingming Yin & Yuan Lu & Sujuan Liu & Minle Zhan & Liyuan Zhao & Zhenyan He & Fanling Meng & Sidan Tian & Liang Luo, 2024. "A microenvironment-modulating dressing with proliferative degradants for the healing of diabetic wounds," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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