IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i13p4854-d380791.html
   My bibliography  Save this article

Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model

Author

Listed:
  • Shiri Kuperman

    (School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel)

  • Ram Efraty

    (Shamir Medical Center, Tel Aviv University, Tel Aviv 6997801, Israel)

  • Ina Arie

    (School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel)

  • Arkadi Rahmanov

    (School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel)

  • Marina Rahmanov Gavrielov

    (School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel)

  • Matityahau Noff

    (Shamir Medical Center, Tel Aviv University, Tel Aviv 6997801, Israel)

  • Ron Fishel

    (Kaplan Medical Center, Hebrew University of Jerusalem, Jerusalem 91905, Israel)

  • Sandu Pitaru

    (School of Dental Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel)

Abstract

Diabetic wounds’ delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs) are a readily accessible source for obtaining large quantities of stem cells. This study evaluates the potential of mouse oral mucosa stem cells (mOMSCs) to enhance wound healing in a diabetic ( db/db ) mouse model by morphological and histological analysis. We show that mOMSCs-treated wounds displayed a significantly faster wound-healing response ( p ≤ 0.0001), featuring faster re-epithelialization and a larger area of granulation tissue ( p ≤ 0.05). Taken together, these results suggest that oral mucosa stem cells might have therapeutic potential in diabetic wound healing.

Suggested Citation

  • Shiri Kuperman & Ram Efraty & Ina Arie & Arkadi Rahmanov & Marina Rahmanov Gavrielov & Matityahau Noff & Ron Fishel & Sandu Pitaru, 2020. "Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model," IJERPH, MDPI, vol. 17(13), pages 1-10, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:13:p:4854-:d:380791
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/13/4854/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/13/4854/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Geoffrey C. Gurtner & Sabine Werner & Yann Barrandon & Michael T. Longaker, 2008. "Wound repair and regeneration," Nature, Nature, vol. 453(7193), pages 314-321, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Li Yang & Dan Zhang & Wenjing Li & Hongbing Lin & Chendi Ding & Qingyun Liu & Liangliang Wang & Zimu Li & Lin Mei & Hongzhong Chen & Yanli Zhao & Xiaowei Zeng, 2023. "Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Du Wenqiang & Ashkan Novin & Yamin Liu & Junaid Afzal & Yasir Suhail & Shaofei Liu & Nicole R. Gavin & Jennifer R. Jorgensen & Christopher M. Morosky & Reinaldo Figueroa & Tannin A. Schmidt & Melinda , 2024. "Scar matrix drives Piezo1 mediated stromal inflammation leading to placenta accreta spectrum," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Sayan Chakraborty & Divyaleka Sampath & Melissa Ong Yu Lin & Matthew Bilton & Cheng-Kuang Huang & Mui Hoon Nai & Kizito Njah & Pierre-Alexis Goy & Cheng-Chun Wang & Ernesto Guccione & Chwee-Teck Lim &, 2021. "Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    4. Shiman Zuo & Yuxin Wang & Hanjing Bao & Zehui Zhang & Nanfei Yang & Meng Jia & Qing Zhang & Ani Jian & Rong Ji & Lidan Zhang & Yan Lu & Yahong Huang & Pingping Shen, 2024. "Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Chantal A. Ten Kate & Hilde J. H. Koese & M. Jenda Hop & André B. Rietman & René M. H. Wijnen & Marijn J. Vermeulen & Claudia M. G. Keyzer-Dekker, 2023. "Psychometric Performance of the Stony Brook Scar Evaluation Scale and SCAR-Q Questionnaire in Dutch Children after Pediatric Surgery," IJERPH, MDPI, vol. 21(1), pages 1-12, December.
    6. Ishier Raote & Ann-Helen Rosendahl & Hanna-Maria Häkkinen & Carina Vibe & Ismail Küçükaylak & Mugdha Sawant & Lena Keufgens & Pia Frommelt & Kai Halwas & Katrina Broadbent & Marina Cunquero & Gustavo , 2024. "TANGO1 inhibitors reduce collagen secretion and limit tissue scarring," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    7. Diana Boraschi & Dongjie Li & Yang Li & Paola Italiani, 2021. "In Vitro and In Vivo Models to Assess the Immune-Related Effects of Nanomaterials," IJERPH, MDPI, vol. 18(22), pages 1-16, November.
    8. Yonger Xue & Yuebao Zhang & Yichen Zhong & Shi Du & Xucheng Hou & Wenqing Li & Haoyuan Li & Siyu Wang & Chang Wang & Jingyue Yan & Diana D. Kang & Binbin Deng & David W. McComb & Darrell J. Irvine & R, 2024. "LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    9. Xiaoxue Han & Chaimongkol Saengow & Leah Ju & Wen Ren & Randy H. Ewoldt & Joseph Irudayaraj, 2024. "Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    10. Akio Nishijima & Akio Nishijima & Takahiro Fujimoto & Junko Nishijima & Akio Nishijima & Takahiro Fujimoto & Takamichi Hirata & Junko Nishijima, 2019. "A New Energy Device for Skin Activation to Acute Wound Using Cold Atmospheric Pressure Plasma- A Randomized Controlled Clinical Trial," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 21(1), pages 15494-15501, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:13:p:4854-:d:380791. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.