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Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances and Future Perspectives

Author

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  • Sònia Torres

    (Department of Electronic Engineering, Universitat Rovira i Virgili, Països Catalans 26, 43007 Tarragona, Spain
    Both authors contributed equally to the paper.)

  • Carla Merino

    (Department of Electronic Engineering, Universitat Rovira i Virgili, Països Catalans 26, 43007 Tarragona, Spain
    Both authors contributed equally to the paper.)

  • Beatrix Paton

    (Department of Electronic Engineering, Universitat Rovira i Virgili, Països Catalans 26, 43007 Tarragona, Spain)

  • Xavier Correig

    (Department of Electronic Engineering, Universitat Rovira i Virgili, Països Catalans 26, 43007 Tarragona, Spain
    Institut d’Investigació Sanitària Pere Virgili, Escorxador s/n, 43003 Tarragona, Spain
    CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Carlos III Health Institute, Monforte de Lemos 3-5, 28029 Madrid, Spain)

  • Noelia Ramírez

    (Department of Electronic Engineering, Universitat Rovira i Virgili, Països Catalans 26, 43007 Tarragona, Spain
    Institut d’Investigació Sanitària Pere Virgili, Escorxador s/n, 43003 Tarragona, Spain
    CIBERDEM, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Carlos III Health Institute, Monforte de Lemos 3-5, 28029 Madrid, Spain)

Abstract

Smoking is the leading preventable disease worldwide and passive smoking is estimated to be the cause of about 1.0% of worldwide mortality. The determination of tobacco smoke biomarkers in human biological matrices is key to assess the health effects related to the exposure to environmental tobacco smoke. The biomonitoring of cotinine, the main nicotine metabolite, in human biofluids—including urine, serum or saliva—has been extensively used to assess this exposure. However, the simultaneous determination of cotinine together with other tobacco biomarkers and the selection of alternative biological matrices, such as hair, skin or exhaled breath, would enable a better characterization of the kind and extent of tobacco exposure. This review aims to perform a critical analysis of the up-to-date literature focused on the simultaneous determination of multiple tobacco smoke biomarkers studied in different biological matrices, due to the exposure to secondhand smoke (SHS) and thirdhand smoke (THS). Target biomarkers included both tobacco-specific biomarkers—nicotine and tobacco specific nitrosamine biomarkers—and tobacco-related biomarkers, such as those from polycyclic aromatic hydrocarbons, volatile organic compounds, metals and carbon monoxide. To conclude, we discuss the suitability of determining multiple biomarkers through several relevant examples of SHS and THS exposure.

Suggested Citation

  • Sònia Torres & Carla Merino & Beatrix Paton & Xavier Correig & Noelia Ramírez, 2018. "Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances and Future Perspectives," IJERPH, MDPI, vol. 15(12), pages 1-25, November.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:12:p:2693-:d:186356
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    References listed on IDEAS

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    1. Reinskje Talhout & Thomas Schulz & Ewa Florek & Jan Van Benthem & Piet Wester & Antoon Opperhuizen, 2011. "Hazardous Compounds in Tobacco Smoke," IJERPH, MDPI, vol. 8(2), pages 1-16, February.
    2. Sungroul Kim & Benjamin J. Apelberg & Erika Avila-Tang & Lisa Hepp & Dongmin Yun & Jonathan M. Samet & Patrick N. Breysse, 2014. "Utility and Cutoff Value of Hair Nicotine as a Biomarker of Long-Term Tobacco Smoke Exposure, Compared to Salivary Cotinine," IJERPH, MDPI, vol. 11(8), pages 1-15, August.
    3. Jeonghoon Kim & Kiyoung Lee & Ho-Jang Kwon & Do Hoon Lee & KyooSang Kim, 2016. "Association between Secondhand Smoke in Hospitality Venues and Urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol Concentrations in Non-Smoking Staff," IJERPH, MDPI, vol. 13(11), pages 1-11, November.
    4. Joseph, A. & Spector, L. & Wickham, K. & Janis, G. & Winickoff, J. & Lindgren, B. & Murphy, S., 2013. "Biomarker evidence of tobacco smoke exposure in children participating in lead screening," American Journal of Public Health, American Public Health Association, vol. 103(12), pages 54-59.
    5. Patricia Richter & Obaid Faroon & R. Steven Pappas, 2017. "Cadmium and Cadmium/Zinc Ratios and Tobacco-Related Morbidities," IJERPH, MDPI, vol. 14(10), pages 1-19, September.
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    Cited by:

    1. E. Melinda Mahabee-Gittens & Matthew J. Mazzella & John T. Doucette & Ashley L. Merianos & Lara Stone & Chase A. Wullenweber & Stefanie A. Busgang & Georg E. Matt, 2020. "Comparison of Liquid Chromatography Mass Spectrometry and Enzyme-Linked Immunosorbent Assay Methods to Measure Salivary Cotinine Levels in Ill Children," IJERPH, MDPI, vol. 17(4), pages 1-12, February.
    2. E. Melinda Mahabee-Gittens & Georg E. Matt & Roman A. Jandarov & Ashley L. Merianos, 2023. "The Associations of Trans -3′-Hydroxy Cotinine, Cotinine, and the Nicotine Metabolite Ratio in Pediatric Patients with Tobacco Smoke Exposure," IJERPH, MDPI, vol. 20(9), pages 1-12, April.
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    5. Xuan Zhang & Lu Yang & Hao Zhang & Wanli Xing & Yan Wang & Pengchu Bai & Lulu Zhang & Kazuichi Hayakawa & Akira Toriba & Yongjie Wei & Ning Tang, 2021. "Assessing Approaches of Human Inhalation Exposure to Polycyclic Aromatic Hydrocarbons: A Review," IJERPH, MDPI, vol. 18(6), pages 1-14, March.
    6. Changlin Han & Yangqun Liu & Xiao Gong & Xiaohua Ye & Junli Zhou, 2019. "Relationship between Secondhand Smoke Exposure and Depressive Symptoms: A Systematic Review and Dose–Response Meta-Analysis," IJERPH, MDPI, vol. 16(8), pages 1-14, April.
    7. Shamshad Karatela & Christin Coomarasamy & Janis Paterson & Neil I. Ward, 2019. "Household Smoking Status and Heavy Metal Concentrations in Toenails of Children," IJERPH, MDPI, vol. 16(20), pages 1-12, October.
    8. Yukiko Nishihama & Shoji F. Nakayama & Takahiro Tabuchi & Tomohiko Isobe & Chau-Ren Jung & Miyuki Iwai-Shimada & Yayoi Kobayashi & Takehiro Michikawa & Makiko Sekiyama & Yu Taniguchi & Hiroshi Nitta &, 2020. "Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)," IJERPH, MDPI, vol. 17(15), pages 1-13, July.
    9. Jiyeon Yang & Shervin Hashemi & Wonseok Han & Yoojin Song & Youngwook Lim, 2022. "Exposure and Risk Assessment of Second- and Third-Hand Tobacco Smoke Using Urinary Cotinine Levels in South Korea," IJERPH, MDPI, vol. 19(6), pages 1-19, March.
    10. Arianna Antonucci & Matteo Vitali & Stefano Martellucci & Vincenzo Mattei & Carmela Protano, 2020. "A Cross-Sectional Study on Benzene Exposure in Pediatric Age and Parental Smoking Habits at Home," IJERPH, MDPI, vol. 17(15), pages 1-17, July.
    11. Vittoria Cammalleri & Daniela Marotta & Carmela Protano & Matteo Vitali & Paolo Villari & Maria Sofia Cattaruzza & on behalf of the Smoke-free Department Working Group, 2020. "How Do Combustion and Non-Combustion Products Used Outdoors Affect Outdoor and Indoor Particulate Matter Levels? A Field Evaluation Near the Entrance of an Italian University Library," IJERPH, MDPI, vol. 17(14), pages 1-15, July.
    12. E. Melinda Mahabee-Gittens & Georg E. Matt & Lili Ding & Ashley L. Merianos, 2021. "Comparison of Levels of Three Tobacco Smoke Exposure Biomarkers in Children of Smokers," IJERPH, MDPI, vol. 18(22), pages 1-12, November.

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