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Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)

Author

Listed:
  • Yukiko Nishihama

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • Shoji F. Nakayama

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • Takahiro Tabuchi

    (Cancer Control Center, Osaka International Cancer Institute, Osaka 541-8567, Japan)

  • Tomohiko Isobe

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • Chau-Ren Jung

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • Miyuki Iwai-Shimada

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • Yayoi Kobayashi

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • Takehiro Michikawa

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan
    Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo 143-8540, Japan)

  • Makiko Sekiyama

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • Yu Taniguchi

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • Hiroshi Nitta

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • Shin Yamazaki

    (Japan Environment and Children’s Study Programme Office, Centre for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki 305-0053, Japan)

  • on behalf of the Japan Environment and Children’s Study Group

    (Membership of the Japan Environment and Children’s Study Group is provided in the Acknowledgments.)

Abstract

Few studies have assessed the accuracy of self-reported questionnaires to determine smoking habits relative to urinary biomarkers. This study investigated urinary cotinine cut-off concentrations distinguishing active, passive and non-smokers among pregnant women who participated in the Japan Environment and Children’s Study, a nationwide birth cohort study. Pregnant participants with measured urinary cotinine concentrations (UCCs) and who completed self-reported questionnaires on smoking status were included ( n = 89,895). The cut-off values (COVs) for active and passive smokers were calculated by fitting mixed normal distribution functions to UCCs. The sensitivity and specificity of the questionnaires were subsequently evaluated. The median (interquartile range) UCC was 0.24 (0.083–0.96) µg/g-creatinine, with the detection rate of 89%. The COV for distinguishing active smokers from passive and non-smokers was 36.8 µg/g-creatinine. When this COV was considered to represent the true condition, the questionnaire had a sensitivity of 0.523, a specificity of 0.998, a positive predictive value (PPV) of 0.967 and a negative predictive value (NPV) of 0.957. The COV for distinguishing passive smokers from non-smokers was 0.31 µg/g-creatinine, with the questionnaire having a sensitivity of 0.222, a specificity of 0.977, a PPV of 0.868 and an NPV of 0.644. As many as 78% of passive smokers might be misclassified as non-smokers.

Suggested Citation

  • Yukiko Nishihama & Shoji F. Nakayama & Takahiro Tabuchi & Tomohiko Isobe & Chau-Ren Jung & Miyuki Iwai-Shimada & Yayoi Kobayashi & Takehiro Michikawa & Makiko Sekiyama & Yu Taniguchi & Hiroshi Nitta &, 2020. "Determination of Urinary Cotinine Cut-Off Concentrations for Pregnant Women in the Japan Environment and Children’s Study (JECS)," IJERPH, MDPI, vol. 17(15), pages 1-13, July.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:15:p:5537-:d:392550
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    References listed on IDEAS

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    1. Sònia Torres & Carla Merino & Beatrix Paton & Xavier Correig & Noelia Ramírez, 2018. "Biomarkers of Exposure to Secondhand and Thirdhand Tobacco Smoke: Recent Advances and Future Perspectives," IJERPH, MDPI, vol. 15(12), pages 1-25, November.
    2. Sungroul Kim, 2016. "Overview of Cotinine Cutoff Values for Smoking Status Classification," IJERPH, MDPI, vol. 13(12), pages 1-15, December.
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    Cited by:

    1. Yoshihiko Hosokawa & Masayoshi Zaitsu & Sumiyo Okawa & Naho Morisaki & Ai Hori & Yukiko Nishihama & Shoji F. Nakayama & Takeo Fujiwara & Hiromi Hamada & Toyomi Satoh & Takahiro Tabuchi, 2022. "Association between Heated Tobacco Product Use during Pregnancy and Fetal Growth in Japan: A Nationwide Web-Based Survey," IJERPH, MDPI, vol. 19(18), pages 1-9, September.

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