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ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans

Author

Listed:
  • Weilin Kong

    (Yunnan University)

  • Guoli Gu

    (Yunnan University)

  • Tong Dai

    (Yunnan University)

  • Beibei Chen

    (Yunnan University)

  • Yanli Wang

    (Yunnan University)

  • Zheng Zeng

    (Yunnan University)

  • Mintie Pu

    (Yunnan University)

Abstract

Variations of individual lifespans within genetically identical populations in homogenous environments are remarkable, with the cause largely unknown. Here, we show the expression dynamic of the Caenorhabditis elegans fatty acid elongase ELO-6 during aging predicts individual longevity in isogenic populations. elo-6 expression is reduced with age. ELO-6 expression level exhibits obvious variation between individuals in mid-aged worms and is positively correlated with lifespan and health span. Interventions that prolong longevity enhance ELO-6 expression stability during aging, indicating ELO-6 is also a populational lifespan predictor. Differentially expressed genes between short-lived and long-lived isogenic worms regulate lifespan and are enriched for PQM-1 binding sites. pqm-1 in young to mid-aged adults causes individual ELO-6 expression heterogeneity and restricts health span and life span. Thus, our study identifies ELO-6 as a predictor of individual and populational lifespan and reveals the role of pqm-1 in causing individual health span variation in the mid-aged C. elegans.

Suggested Citation

  • Weilin Kong & Guoli Gu & Tong Dai & Beibei Chen & Yanli Wang & Zheng Zeng & Mintie Pu, 2024. "ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53887-x
    DOI: 10.1038/s41467-024-53887-x
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    1. Eric L. Greer & Travis J. Maures & Anna G. Hauswirth & Erin M. Green & Dena S. Leeman & Géraldine S. Maro & Shuo Han & Max R. Banko & Or Gozani & Anne Brunet, 2010. "Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans," Nature, Nature, vol. 466(7304), pages 383-387, July.
    2. Thomas Heimbucher & Julian Hog & Piyush Gupta & Coleen T. Murphy, 2020. "PQM-1 controls hypoxic survival via regulation of lipid metabolism," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    3. Daphne Bazopoulou & Daniela Knoefler & Yongxin Zheng & Kathrin Ulrich & Bryndon J. Oleson & Lihan Xie & Minwook Kim & Anke Kaufmann & Young-Tae Lee & Yali Dou & Yong Chen & Shu Quan & Ursula Jakob, 2019. "Developmental ROS individualizes organismal stress resistance and lifespan," Nature, Nature, vol. 576(7786), pages 301-305, December.
    4. Honor Hsin & Cynthia Kenyon, 1999. "Signals from the reproductive system regulate the lifespan of C. elegans," Nature, Nature, vol. 399(6734), pages 362-366, May.
    5. Marjolein J. Peters & Roby Joehanes & Luke C. Pilling & Claudia Schurmann & Karen N. Conneely & Joseph Powell & Eva Reinmaa & George L. Sutphin & Alexandra Zhernakova & Katharina Schramm & Yana A. Wil, 2015. "The transcriptional landscape of age in human peripheral blood," Nature Communications, Nature, vol. 6(1), pages 1-14, December.
    6. En-Zhi Shen & Chun-Qing Song & Yuan Lin & Wen-Hong Zhang & Pei-Fang Su & Wen-Yuan Liu & Pan Zhang & Jiejia Xu & Na Lin & Cheng Zhan & Xianhua Wang & Yu Shyr & Heping Cheng & Meng-Qiu Dong, 2014. "Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans," Nature, Nature, vol. 508(7494), pages 128-132, April.
    7. Yuan Zhao & Ann F. Gilliat & Matthias Ziehm & Mark Turmaine & Hongyuan Wang & Marina Ezcurra & Chenhao Yang & George Phillips & David McBay & William B. Zhang & Linda Partridge & Zachary Pincus & Davi, 2017. "Two forms of death in ageing Caenorhabditis elegans," Nature Communications, Nature, vol. 8(1), pages 1-8, August.
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