IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15458.html
   My bibliography  Save this article

Two forms of death in ageing Caenorhabditis elegans

Author

Listed:
  • Yuan Zhao

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • Ann F. Gilliat

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • Matthias Ziehm

    (Institute of Healthy Ageing, Evolution and Environment, University College London
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK)

  • Mark Turmaine

    (University College London)

  • Hongyuan Wang

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • Marina Ezcurra

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • Chenhao Yang

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • George Phillips

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • David McBay

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • William B. Zhang

    (Washington University in St Louis)

  • Linda Partridge

    (Institute of Healthy Ageing, Evolution and Environment, University College London
    Max Planck Institute for Biology of Ageing)

  • Zachary Pincus

    (Washington University in St Louis)

  • David Gems

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

Abstract

Ageing generates senescent pathologies, some of which cause death. Interventions that delay or prevent lethal pathologies will extend lifespan. Here we identify life-limiting pathologies in Caenorhabditis elegans with a necropsy analysis of worms that have died of old age. Our results imply the presence of multiple causes of death. Specifically, we identify two classes of corpse: early deaths with a swollen pharynx (which we call ‘P deaths’), and later deaths with an atrophied pharynx (termed ‘p deaths’). The effects of interventions on lifespan can be broken down into changes in the frequency and/or timing of either form of death. For example, glp-1 mutation only delays p death, while eat-2 mutation reduces P death. Combining pathology and mortality analysis allows mortality profiles to be deconvolved, providing biological meaning to complex survival and mortality profiles.

Suggested Citation

  • Yuan Zhao & Ann F. Gilliat & Matthias Ziehm & Mark Turmaine & Hongyuan Wang & Marina Ezcurra & Chenhao Yang & George Phillips & David McBay & William B. Zhang & Linda Partridge & Zachary Pincus & Davi, 2017. "Two forms of death in ageing Caenorhabditis elegans," Nature Communications, Nature, vol. 8(1), pages 1-8, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15458
    DOI: 10.1038/ncomms15458
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15458
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15458?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kan Xie & Helmut Fuchs & Enzo Scifo & Dan Liu & Ahmad Aziz & Juan Antonio Aguilar-Pimentel & Oana Veronica Amarie & Lore Becker & Patricia da Silva-Buttkus & Julia Calzada-Wack & Yi-Li Cho & Yushuang , 2022. "Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice," Nature Communications, Nature, vol. 13(1), pages 1-29, December.
    2. Drew Benjamin Sinha & Zachary Scott Pincus, 2022. "High temporal resolution measurements of movement reveal novel early-life physiological decline in C. elegans," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-17, February.
    3. Carina C. Kern & Shivangi Srivastava & Marina Ezcurra & Kuei Ching Hsiung & Nancy Hui & StJohn Townsend & Dominik Maczik & Bruce Zhang & Victoria Tse & Viktoras Konstantellos & Jürg Bähler & David Gem, 2023. "C. elegans ageing is accelerated by a self-destructive reproductive programme," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15458. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.