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Two forms of death in ageing Caenorhabditis elegans

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  • Yuan Zhao

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • Ann F. Gilliat

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • Matthias Ziehm

    (Institute of Healthy Ageing, Evolution and Environment, University College London
    European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK)

  • Mark Turmaine

    (University College London)

  • Hongyuan Wang

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • Marina Ezcurra

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • Chenhao Yang

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • George Phillips

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • David McBay

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

  • William B. Zhang

    (Washington University in St Louis)

  • Linda Partridge

    (Institute of Healthy Ageing, Evolution and Environment, University College London
    Max Planck Institute for Biology of Ageing)

  • Zachary Pincus

    (Washington University in St Louis)

  • David Gems

    (Institute of Healthy Ageing, Evolution and Environment, University College London)

Abstract

Ageing generates senescent pathologies, some of which cause death. Interventions that delay or prevent lethal pathologies will extend lifespan. Here we identify life-limiting pathologies in Caenorhabditis elegans with a necropsy analysis of worms that have died of old age. Our results imply the presence of multiple causes of death. Specifically, we identify two classes of corpse: early deaths with a swollen pharynx (which we call ‘P deaths’), and later deaths with an atrophied pharynx (termed ‘p deaths’). The effects of interventions on lifespan can be broken down into changes in the frequency and/or timing of either form of death. For example, glp-1 mutation only delays p death, while eat-2 mutation reduces P death. Combining pathology and mortality analysis allows mortality profiles to be deconvolved, providing biological meaning to complex survival and mortality profiles.

Suggested Citation

  • Yuan Zhao & Ann F. Gilliat & Matthias Ziehm & Mark Turmaine & Hongyuan Wang & Marina Ezcurra & Chenhao Yang & George Phillips & David McBay & William B. Zhang & Linda Partridge & Zachary Pincus & Davi, 2017. "Two forms of death in ageing Caenorhabditis elegans," Nature Communications, Nature, vol. 8(1), pages 1-8, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15458
    DOI: 10.1038/ncomms15458
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    Cited by:

    1. Kan Xie & Helmut Fuchs & Enzo Scifo & Dan Liu & Ahmad Aziz & Juan Antonio Aguilar-Pimentel & Oana Veronica Amarie & Lore Becker & Patricia da Silva-Buttkus & Julia Calzada-Wack & Yi-Li Cho & Yushuang , 2022. "Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice," Nature Communications, Nature, vol. 13(1), pages 1-29, December.
    2. Drew Benjamin Sinha & Zachary Scott Pincus, 2022. "High temporal resolution measurements of movement reveal novel early-life physiological decline in C. elegans," PLOS ONE, Public Library of Science, vol. 17(2), pages 1-17, February.
    3. Weilin Kong & Guoli Gu & Tong Dai & Beibei Chen & Yanli Wang & Zheng Zeng & Mintie Pu, 2024. "ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Carina C. Kern & Shivangi Srivastava & Marina Ezcurra & Kuei Ching Hsiung & Nancy Hui & StJohn Townsend & Dominik Maczik & Bruce Zhang & Victoria Tse & Viktoras Konstantellos & Jürg Bähler & David Gem, 2023. "C. elegans ageing is accelerated by a self-destructive reproductive programme," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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