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Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice

Author

Listed:
  • Kan Xie

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Helmut Fuchs

    (German Research Center for Environmental Health)

  • Enzo Scifo

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Dan Liu

    (Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE))

  • Ahmad Aziz

    (Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE)
    University of Bonn)

  • Juan Antonio Aguilar-Pimentel

    (German Research Center for Environmental Health)

  • Oana Veronica Amarie

    (German Research Center for Environmental Health)

  • Lore Becker

    (German Research Center for Environmental Health)

  • Patricia da Silva-Buttkus

    (German Research Center for Environmental Health)

  • Julia Calzada-Wack

    (German Research Center for Environmental Health)

  • Yi-Li Cho

    (German Research Center for Environmental Health)

  • Yushuang Deng

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

  • A. Cole Edwards

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Lillian Garrett

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Christina Georgopoulou

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Raffaele Gerlini

    (German Research Center for Environmental Health)

  • Sabine M. Hölter

    (German Research Center for Environmental Health
    German Research Center for Environmental Health)

  • Tanja Klein-Rodewald

    (German Research Center for Environmental Health)

  • Michael Kramer

    (GEMoaB GmbH)

  • Stefanie Leuchtenberger

    (German Research Center for Environmental Health)

  • Dimitra Lountzi

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Phillip Mayer-Kuckuk

    (German Research Center for Environmental Health)

  • Lena L. Nover

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Manuela A. Oestereicher

    (German Research Center for Environmental Health)

  • Clemens Overkott

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Brandon L. Pearson

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE)
    Columbia University)

  • Birgit Rathkolb

    (German Research Center for Environmental Health
    Member of German Center for Diabetes Research (DZD)
    Ludwig-Maximilians-University Munich)

  • Jan Rozman

    (German Research Center for Environmental Health
    Member of German Center for Diabetes Research (DZD)
    Institute of Molecular Genetics of the Czech Academy of Sciences, Czech Centre for Phenogenomics)

  • Jenny Russ

    (Nuclear Function Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Kristina Schaaf

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Nadine Spielmann

    (German Research Center for Environmental Health)

  • Adrián Sanz-Moreno

    (German Research Center for Environmental Health)

  • Claudia Stoeger

    (German Research Center for Environmental Health)

  • Irina Treise

    (German Research Center for Environmental Health)

  • Daniele Bano

    (Aging and Neurodegeneration Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Dirk H. Busch

    (Technische Universität München)

  • Jochen Graw

    (German Research Center for Environmental Health)

  • Martin Klingenspor

    (Technische Universität München)

  • Thomas Klopstock

    (Ludwig-Maximilians-University Munich
    DZNE, German Center for Neurodegenerative Diseases
    Munich Cluster for Systems Neurology (SyNergy))

  • Beverly A. Mock

    (Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH)

  • Paolo Salomoni

    (Nuclear Function Lab, German Center for Neurodegenerative Diseases (DZNE))

  • Carsten Schmidt-Weber

    (Center of Allergy & Environment (ZAUM), Technische Universität München, and Helmholtz Zentrum München)

  • Marco Weiergräber

    (Research Group Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices)

  • Eckhard Wolf

    (Ludwig-Maximilians-University Munich)

  • Wolfgang Wurst

    (German Research Center for Environmental Health
    DZNE, German Center for Neurodegenerative Diseases
    Technische Universität München)

  • Valérie Gailus-Durner

    (German Research Center for Environmental Health)

  • Monique M. B. Breteler

    (Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE)
    University of Bonn)

  • Martin Hrabě de Angelis

    (German Research Center for Environmental Health
    Member of German Center for Diabetes Research (DZD)
    Technische Universität München)

  • Dan Ehninger

    (Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE))

Abstract

Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific pathologies. Here, we employ large-scale phenotyping to analyze hundreds of markers in aging male C57BL/6J mice. For each phenotype, we establish lifetime profiles to determine when age-dependent change is first detectable relative to the young adult baseline. We examine key lifespan regulators (putative anti-aging interventions; PAAIs) for a possible countering of aging. Importantly, unlike most previous studies, we include in our study design young treated groups of animals, subjected to PAAIs prior to the onset of detectable age-dependent phenotypic change. Many PAAI effects influence phenotypes long before the onset of detectable age-dependent change, but, importantly, do not alter the rate of phenotypic change. Hence, these PAAIs have limited effects on aging.

Suggested Citation

  • Kan Xie & Helmut Fuchs & Enzo Scifo & Dan Liu & Ahmad Aziz & Juan Antonio Aguilar-Pimentel & Oana Veronica Amarie & Lore Becker & Patricia da Silva-Buttkus & Julia Calzada-Wack & Yi-Li Cho & Yushuang , 2022. "Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice," Nature Communications, Nature, vol. 13(1), pages 1-29, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34515-y
    DOI: 10.1038/s41467-022-34515-y
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    References listed on IDEAS

    as
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