IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v466y2010i7304d10.1038_nature09195.html
   My bibliography  Save this article

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

Author

Listed:
  • Eric L. Greer

    (Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Cancer Biology Graduate Program, Stanford University, Stanford, California 94305, USA)

  • Travis J. Maures

    (Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA)

  • Anna G. Hauswirth

    (Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA)

  • Erin M. Green

    (Stanford University, Stanford, California 94305, USA)

  • Dena S. Leeman

    (Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Cancer Biology Graduate Program, Stanford University, Stanford, California 94305, USA)

  • Géraldine S. Maro

    (Stanford University, Stanford, California 94305, USA)

  • Shuo Han

    (Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA)

  • Max R. Banko

    (Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA)

  • Or Gozani

    (Cancer Biology Graduate Program, Stanford University, Stanford, California 94305, USA
    Stanford University, Stanford, California 94305, USA)

  • Anne Brunet

    (Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA
    Cancer Biology Graduate Program, Stanford University, Stanford, California 94305, USA)

Abstract

Methylation adds to lifespan Genes of the Sir2 family are known to influence longevity in yeast, in the worm Caenorhabditis elegans and in other organisms through an effect on histone deacetylation. This raises the question of whether other histone modifications also influence longevity. Greer et al. show that histone methylation regulates lifespan determination in C. elegans. Deficiencies in components of a conserved chromatin protein complex known as the ASH-2 complex, which trimethylates histone H3 at lysine 4 (H3K4), all extend worm lifespan. Conversely, the H3K4 demethylase RBR-2 is required for normal lifespan, consistent with the idea that an excess of H3K4 trimethylation shortens lifespan. This increase in longevity requires the presence of an intact adult germline and the continuous production of mature eggs, which suggests that the lifespan of the soma is regulated by an H3K4 methyltransferase/demethylase complex in the germline.

Suggested Citation

  • Eric L. Greer & Travis J. Maures & Anna G. Hauswirth & Erin M. Green & Dena S. Leeman & Géraldine S. Maro & Shuo Han & Max R. Banko & Or Gozani & Anne Brunet, 2010. "Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans," Nature, Nature, vol. 466(7304), pages 383-387, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7304:d:10.1038_nature09195
    DOI: 10.1038/nature09195
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09195
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09195?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Weilin Kong & Guoli Gu & Tong Dai & Beibei Chen & Yanli Wang & Zheng Zeng & Mintie Pu, 2024. "ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Xinhao Hou & Mingjing Xu & Chengming Zhu & Jianing Gao & Meili Li & Xiangyang Chen & Cheng Sun & Björn Nashan & Jianye Zang & Ying Zhou & Shouhong Guang & Xuezhu Feng, 2023. "Systematic characterization of chromodomain proteins reveals an H3K9me1/2 reader regulating aging in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Ana Cristina Laranjeira & Simon Berger & Tea Kohlbrenner & Nadja R. Greter & Alex Hajnal, 2024. "Nutritional vitamin B12 regulates RAS/MAPK-mediated cell fate decisions through one-carbon metabolism," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Shengjie Fan & Yingxuan Yan & Ying Xia & Zhenyu Zhou & Lingling Luo & Mengnan Zhu & Yongli Han & Deqiang Yao & Lijun Zhang & Minglv Fang & Lina Peng & Jing Yu & Ying Liu & Xiaoyan Gao & Huida Guan & H, 2023. "Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:466:y:2010:i:7304:d:10.1038_nature09195. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.