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Developmental ROS individualizes organismal stress resistance and lifespan

Author

Listed:
  • Daphne Bazopoulou

    (University of Michigan)

  • Daniela Knoefler

    (University of Michigan)

  • Yongxin Zheng

    (East China University of Science and Technology
    Shanghai Collaborative Innovation Center for Biomanufacturing (SCICB))

  • Kathrin Ulrich

    (University of Michigan)

  • Bryndon J. Oleson

    (University of Michigan)

  • Lihan Xie

    (University of Michigan)

  • Minwook Kim

    (University of Michigan)

  • Anke Kaufmann

    (University of Michigan)

  • Young-Tae Lee

    (Michigan Medicine)

  • Yali Dou

    (Michigan Medicine)

  • Yong Chen

    (National Center for Protein Science Shanghai, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences)

  • Shu Quan

    (East China University of Science and Technology
    Shanghai Collaborative Innovation Center for Biomanufacturing (SCICB))

  • Ursula Jakob

    (University of Michigan)

Abstract

A central aspect of aging research concerns the question of when individuality in lifespan arises1. Here we show that a transient increase in reactive oxygen species (ROS), which occurs naturally during early development in a subpopulation of synchronized Caenorhabditis elegans, sets processes in motion that increase stress resistance, improve redox homeostasis and ultimately prolong lifespan in those animals. We find that these effects are linked to the global ROS-mediated decrease in developmental histone H3K4me3 levels. Studies in HeLa cells confirmed that global H3K4me3 levels are ROS-sensitive and that depletion of H3K4me3 levels increases stress resistance in mammalian cell cultures. In vitro studies identified SET1/MLL histone methyltransferases as redox sensitive units of the H3K4-trimethylating complex of proteins (COMPASS). Our findings implicate a link between early-life events, ROS-sensitive epigenetic marks, stress resistance and lifespan.

Suggested Citation

  • Daphne Bazopoulou & Daniela Knoefler & Yongxin Zheng & Kathrin Ulrich & Bryndon J. Oleson & Lihan Xie & Minwook Kim & Anke Kaufmann & Young-Tae Lee & Yali Dou & Yong Chen & Shu Quan & Ursula Jakob, 2019. "Developmental ROS individualizes organismal stress resistance and lifespan," Nature, Nature, vol. 576(7786), pages 301-305, December.
    • Handle: RePEc:nat:nature:v:576:y:2019:i:7786:d:10.1038_s41586-019-1814-y
    DOI: 10.1038/s41586-019-1814-y
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    Cited by:

    1. Chi Liu & Xiaoliang Liu & Zhongwei He & Jiangping Zhang & Xiaoqin Tan & Wenmin Yang & Yunfeng Zhang & Ting Yu & Shuyi Liao & Lu Dai & Zhi Xu & Furong Li & Yinghui Huang & Jinghong Zhao, 2023. "Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Weilin Kong & Guoli Gu & Tong Dai & Beibei Chen & Yanli Wang & Zheng Zeng & Mintie Pu, 2024. "ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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