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An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress

Author

Listed:
  • Carlos A. Vergani-Junior

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • Raíssa De P. Moro

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • Silas Pinto

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • Evandro A. De-Souza

    (Universidade Estadual de Campinas)

  • Henrique Camara

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas
    Joslin Diabetes Center)

  • Deisi L. Braga

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • Guilherme Tonon-da-Silva

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • Thiago L. Knittel

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • Gabriel P. Ruiz

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • Raissa G. Ludwig

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • Katlin B. Massirer

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • William B. Mair

    (Harvard University)

  • Marcelo A. Mori

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas
    Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

Abstract

Cellular response to redox imbalance is crucial for organismal health. microRNAs are implicated in stress responses. ALG-1, the C. elegans ortholog of human AGO2, plays an essential role in microRNA processing and function. Here we investigated the mechanisms governing ALG-1 expression in C. elegans and the players controlling lifespan and stress resistance downstream of ALG-1. We show that upregulation of ALG-1 is a shared feature in conditions linked to increased longevity (e.g., germline-deficient glp-1 mutants). ALG-1 knockdown reduces lifespan and oxidative stress resistance, while overexpression enhances survival against pro-oxidant agents but not heat or reductive stress. R02D3.7 represses alg-1 expression, impacting oxidative stress resistance at least in part via ALG-1. microRNAs upregulated in glp-1 mutants (miR-87-3p, miR-230-3p, and miR-235-3p) can target genes in the protein disulfide isomerase pathway and protect against oxidative stress. This study unveils a tightly regulated network involving transcription factors and microRNAs which controls organisms’ ability to withstand oxidative stress.

Suggested Citation

  • Carlos A. Vergani-Junior & Raíssa De P. Moro & Silas Pinto & Evandro A. De-Souza & Henrique Camara & Deisi L. Braga & Guilherme Tonon-da-Silva & Thiago L. Knittel & Gabriel P. Ruiz & Raissa G. Ludwig , 2024. "An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47306-4
    DOI: 10.1038/s41467-024-47306-4
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    References listed on IDEAS

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