IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-18369-w.html
   My bibliography  Save this article

PQM-1 controls hypoxic survival via regulation of lipid metabolism

Author

Listed:
  • Thomas Heimbucher

    (Princeton University
    Princeton University
    University of Freiburg)

  • Julian Hog

    (University of Freiburg)

  • Piyush Gupta

    (University of Freiburg)

  • Coleen T. Murphy

    (Princeton University
    Princeton University)

Abstract

Animals have evolved responses to low oxygen conditions to ensure their survival. Here, we have identified the C. elegans zinc finger transcription factor PQM-1 as a regulator of the hypoxic stress response. PQM-1 is required for the longevity of insulin signaling mutants, but surprisingly, loss of PQM-1 increases survival under hypoxic conditions. PQM-1 functions as a metabolic regulator by controlling oxygen consumption rates, suppressing hypoxic glycogen levels, and inhibiting the expression of the sorbitol dehydrogenase-1 SODH-1, a crucial sugar metabolism enzyme. PQM-1 promotes hypoxic fat metabolism by maintaining the expression of the stearoyl-CoA desaturase FAT-7, an oxygen consuming, rate-limiting enzyme in fatty acid biosynthesis. PQM-1 activity positively regulates fat transport to developing oocytes through vitellogenins under hypoxic conditions, thereby increasing survival rates of arrested progeny during hypoxia. Thus, while pqm-1 mutants increase survival of mothers, ultimately this loss is detrimental to progeny survival. Our data support a model in which PQM-1 controls a trade-off between lipid metabolic activity in the mother and her progeny to promote the survival of the species under hypoxic conditions.

Suggested Citation

  • Thomas Heimbucher & Julian Hog & Piyush Gupta & Coleen T. Murphy, 2020. "PQM-1 controls hypoxic survival via regulation of lipid metabolism," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18369-w
    DOI: 10.1038/s41467-020-18369-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-18369-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-18369-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Weilin Kong & Guoli Gu & Tong Dai & Beibei Chen & Yanli Wang & Zheng Zeng & Mintie Pu, 2024. "ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Mehul Vora & Stephanie M. Pyonteck & Tatiana Popovitchenko & Tarmie L. Matlack & Aparna Prashar & Nanci S. Kane & John Favate & Premal Shah & Christopher Rongo, 2022. "The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-18369-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.