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Atomic-scale strain engineering of atomically resolved Pt clusters transcending natural enzymes

Author

Listed:
  • Ke Chen

    (Tianjin University)

  • Guo Li

    (Tianjin University)

  • Xiaoqun Gong

    (Tianjin University)

  • Qinjuan Ren

    (Tianjin University)

  • Junying Wang

    (University of North Carolina at Chapel Hill)

  • Shuang Zhao

    (Tianjin University)

  • Ling Liu

    (Tianjin University)

  • Yuxing Yan

    (Tianjin University)

  • Qingshan Liu

    (Tianjin University)

  • Yang Cao

    (Tianjin University)

  • Yaoyao Ren

    (Tianjin Medical University General Hospital)

  • Qiong Qin

    (Tianjin Medical University General Hospital)

  • Qi Xin

    (Tianjin University)

  • Shu-Lin Liu

    (Nankai University)

  • Peiyu Yao

    (Nankai University)

  • Bo Zhang

    (Southern University of Science and Technology)

  • Jingkai Yang

    (Southern University of Science and Technology)

  • Ruoli Zhao

    (Tianjin University)

  • Yuan Li

    (Tianjin University)

  • Ran Luo

    (Tianjin University)

  • Yikai Fu

    (Tianjin University)

  • Yonghui Li

    (Tianjin University)

  • Wei Long

    (Institute of Radiation Medicine Chinese Academy of Medical, Sciences and Peking Union Medical College)

  • Shu Zhang

    (Tianjin Medical University General Hospital)

  • Haitao Dai

    (Tianjin University)

  • Changlong Liu

    (Tianjin University)

  • Jianning Zhang

    (Tianjin Medical University General Hospital)

  • Jin Chang

    (Tianjin University)

  • Xiaoyu Mu

    (Tianjin University
    Tianjin University)

  • Xiao-Dong Zhang

    (Tianjin University
    Tianjin University)

Abstract

Strain engineering plays an important role in tuning electronic structure and improving catalytic capability of biocatalyst, but it is still challenging to modify the atomic-scale strain for specific enzyme-like reactions. Here, we systematically design Pt single atom (Pt1), several Pt atoms (Ptn) and atomically-resolved Pt clusters (Ptc) on PdAu biocatalysts to investigate the correlation between atomic strain and enzyme-like catalytic activity by experimental technology and in-depth Density Functional Theory calculations. It is found that Ptc on PdAu (Ptc-PA) with reasonable atomic strain upshifts the d-band center and exposes high potential surface, indicating the sufficient active sites to achieve superior biocatalytic performances. Besides, the Pd shell and Au core serve as storage layers providing abundant energetic charge carriers. The Ptc-PA exhibits a prominent peroxidase (POD)-like activity with the catalytic efficiency (Kcat/Km) of 1.50 × 109 mM−1 min−1, about four orders of magnitude higher than natural horseradish peroxidase (HRP), while catalase (CAT)-like and superoxide dismutase (SOD)-like activities of Ptc-PA are also comparable to those of natural enzymes. Biological experiments demonstrate that the detection limit of the Ptc-PA-based catalytic detection system exceeds that of visual inspection by 132-fold in clinical cancer diagnosis. Besides, Ptc-PA can reduce multi-organ acute inflammatory damage and mitigate oxidative stress disorder.

Suggested Citation

  • Ke Chen & Guo Li & Xiaoqun Gong & Qinjuan Ren & Junying Wang & Shuang Zhao & Ling Liu & Yuxing Yan & Qingshan Liu & Yang Cao & Yaoyao Ren & Qiong Qin & Qi Xin & Shu-Lin Liu & Peiyu Yao & Bo Zhang & Ji, 2024. "Atomic-scale strain engineering of atomically resolved Pt clusters transcending natural enzymes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52684-w
    DOI: 10.1038/s41467-024-52684-w
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