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High-throughput preparation of radioprotective polymers via Hantzsch’s reaction for in vivo X-ray damage determination

Author

Listed:
  • Guoqiang Liu

    (Tsinghua University)

  • Yuan Zeng

    (Tsinghua University)

  • Tong Lv

    (Tsinghua University)

  • Tengfei Mao

    (Tsinghua University
    National University of Defense Technology)

  • Yen Wei

    (Tsinghua University)

  • Shunji Jia

    (Tsinghua University)

  • Yanzi Gou

    (National University of Defense Technology)

  • Lei Tao

    (Tsinghua University)

Abstract

Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch’s reaction, high-throughput methods and polymer chemistry. A water-soluble polymer with low-cytotoxicity and an excellent anti-radiation capability has been achieved. In in vivo experiments, this polymer is even better than amifostine, which is the only approved radioprotector for clinical applications, in effectively protecting zebrafish embryos from fatally large doses of ionizing radiation (80 Gy X-ray). A mechanistic study also reveals that the radioprotective ability of this polymer originates from its ability to efficiently prevent DNA damage due to high doses of radiation. This is an initial attempt to explore polymer radioprotectors via a multi-component reaction. It allows exploiting functional polymers and provides the underlying insights to guide the design of radioprotective polymers.

Suggested Citation

  • Guoqiang Liu & Yuan Zeng & Tong Lv & Tengfei Mao & Yen Wei & Shunji Jia & Yanzi Gou & Lei Tao, 2020. "High-throughput preparation of radioprotective polymers via Hantzsch’s reaction for in vivo X-ray damage determination," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-20027-0
    DOI: 10.1038/s41467-020-20027-0
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    Cited by:

    1. Ke Chen & Guo Li & Xiaoqun Gong & Qinjuan Ren & Junying Wang & Shuang Zhao & Ling Liu & Yuxing Yan & Qingshan Liu & Yang Cao & Yaoyao Ren & Qiong Qin & Qi Xin & Shu-Lin Liu & Peiyu Yao & Bo Zhang & Ji, 2024. "Atomic-scale strain engineering of atomically resolved Pt clusters transcending natural enzymes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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