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A natural biogenic nanozyme for scavenging superoxide radicals

Author

Listed:
  • Long Ma

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Jia-Jia Zheng

    (National Center for Nanoscience and Technology of China)

  • Ning Zhou

    (Chinese Academy of Sciences)

  • Ruofei Zhang

    (Chinese Academy of Sciences)

  • Long Fang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yili Yang

    (International Centre for Genetic Engineering and Biotechnology)

  • Xingfa Gao

    (National Center for Nanoscience and Technology of China)

  • Chunying Chen

    (National Center for Nanoscience and Technology)

  • Xiyun Yan

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    Zhengzhou University
    Nanozyme Laboratory in Zhongyuan)

  • Kelong Fan

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    Zhengzhou University
    Nanozyme Laboratory in Zhongyuan)

Abstract

Biominerals, the inorganic minerals of organisms, are known mainly for their physical property-related functions in modern living organisms. Our recent discovery of the enzyme-like activities of nanomaterials, coined as nanozyme, inspires the hypothesis that nano-biominerals might function as enzyme-like catalyzers in cells. Here we report that the iron cores of biogenic ferritins act as natural nanozymes to scavenge superoxide radicals. Through analyzing eighteen representative ferritins from three living kingdoms, we find that the iron core of prokaryote ferritin possesses higher superoxide-diminishing activity than that of eukaryotes. Further investigation reveals that the differences in catalytic capability result from the iron/phosphate ratio changes in the iron core, which is mainly determined by the structures of ferritins. The phosphate in the iron core switches the iron core from single crystalline to amorphous iron phosphate-like structure, resulting in decreased affinity to the hydrogen proton of the ferrihydrite-like core that facilitates its reaction with superoxide in a manner different from that of ferric ions. Furthermore, overexpression of ferritins with high superoxide-diminishing activities in E. coli increases the resistance to superoxide, whereas bacterioferritin knockout or human ferritin knock-in diminishes free radical tolerance, highlighting the physiological antioxidant role of this type of nanozymes.

Suggested Citation

  • Long Ma & Jia-Jia Zheng & Ning Zhou & Ruofei Zhang & Long Fang & Yili Yang & Xingfa Gao & Chunying Chen & Xiyun Yan & Kelong Fan, 2024. "A natural biogenic nanozyme for scavenging superoxide radicals," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44463-w
    DOI: 10.1038/s41467-023-44463-w
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    References listed on IDEAS

    as
    1. Zhenzhen Wang & Jiangjiexing Wu & Jia-Jia Zheng & Xiaomei Shen & Liang Yan & Hui Wei & Xingfa Gao & Yuliang Zhao, 2021. "Accelerated discovery of superoxide-dismutase nanozymes via high-throughput computational screening," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Jinxing Chen & Qian Ma & Minghua Li & Daiyong Chao & Liang Huang & Weiwei Wu & Youxing Fang & Shaojun Dong, 2021. "Glucose-oxidase like catalytic mechanism of noble metal nanozymes," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    3. Kelong Fan & Juqun Xi & Lei Fan & Peixia Wang & Chunhua Zhu & Yan Tang & Xiangdong Xu & Minmin Liang & Bing Jiang & Xiyun Yan & Lizeng Gao, 2018. "In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
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    1. Xiaolong Gao & Huan Wei & Wenjie Ma & Wenjie Wu & Wenliang Ji & Junjie Mao & Ping Yu & Lanqun Mao, 2024. "Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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