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Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation

Author

Listed:
  • Ying Wang

    (Hung Hom)

  • Vinod K. Paidi

    (European Synchrotron Radiation Facility)

  • Weizhen Wang

    (The Hong Kong Polytechnic University, Hung Hom)

  • Yong Wang

    (Hung Hom)

  • Guangri Jia

    (Jilin University)

  • Tingyu Yan

    (Harbin Normal University)

  • Xiaoqiang Cui

    (Jilin University)

  • Songhua Cai

    (The Hong Kong Polytechnic University, Hung Hom)

  • Jingxiang Zhao

    (Harbin Normal University)

  • Kug-Seung Lee

    (Pohang University of Science and Technology (POSTECH))

  • Lawrence Yoon Suk Lee

    (Hung Hom
    Hung Hom)

  • Kwok-Yin Wong

    (Hung Hom)

Abstract

The precise design of single-atom nanozymes (SAzymes) and understanding of their biocatalytic mechanisms hold great promise for developing ideal bio-enzyme substitutes. While considerable efforts have been directed towards mimicking partial bio-inspired structures, the integration of heterogeneous SAzymes configurations and homogeneous enzyme-like mechanism remains an enormous challenge. Here, we show a spatial engineering strategy to fabricate dual-sites SAzymes with atomic Fe active center and adjacent Cu sites. Compared to planar Fe–Cu dual-atomic sites, vertically stacked Fe–Cu geometry in FePc@2D-Cu–N–C possesses highly optimized scaffolds, favorable substrate affinity, and fast electron transfer. These characteristics of FePc@2D-Cu–N–C SAzyme induces biomimetic O2 activation through homogenous enzymatic pathway, resembling functional and mechanistic similarity to natural cytochrome c oxidase. Furthermore, it presents an appealing alternative of cytochrome P450 3A4 for drug metabolism and drug–drug interaction. These findings are expected to deepen the fundamental understanding of atomic-level design in next-generation bio-inspired nanozymes.

Suggested Citation

  • Ying Wang & Vinod K. Paidi & Weizhen Wang & Yong Wang & Guangri Jia & Tingyu Yan & Xiaoqiang Cui & Songhua Cai & Jingxiang Zhao & Kug-Seung Lee & Lawrence Yoon Suk Lee & Kwok-Yin Wong, 2024. "Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46528-w
    DOI: 10.1038/s41467-024-46528-w
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    as
    1. Shaofang Zhang & Yonghui Li & Si Sun & Ling Liu & Xiaoyu Mu & Shuhu Liu & Menglu Jiao & Xinzhu Chen & Ke Chen & Huizhen Ma & Tuo Li & Xiaoyu Liu & Hao Wang & Jianning Zhang & Jiang Yang & Xiao-Dong Zh, 2022. "Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Kejun Chen & Kang Liu & Pengda An & Huangjingwei Li & Yiyang Lin & Junhua Hu & Chuankun Jia & Junwei Fu & Hongmei Li & Hui Liu & Zhang Lin & Wenzhang Li & Jiahang Li & Ying-Rui Lu & Ting-Shan Chan & N, 2020. "Iron phthalocyanine with coordination induced electronic localization to boost oxygen reduction reaction," Nature Communications, Nature, vol. 11(1), pages 1-8, December.
    3. Hongzhou Yang & Lu Shang & Qinghua Zhang & Run Shi & Geoffrey I. N. Waterhouse & Lin Gu & Tierui Zhang, 2019. "A universal ligand mediated method for large scale synthesis of transition metal single atom catalysts," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    4. Xing Zhang & Zishan Wu & Xiao Zhang & Liewu Li & Yanyan Li & Haomin Xu & Xiaoxiao Li & Xiaolu Yu & Zisheng Zhang & Yongye Liang & Hailiang Wang, 2017. "Highly selective and active CO2 reduction electrocatalysts based on cobalt phthalocyanine/carbon nanotube hybrid structures," Nature Communications, Nature, vol. 8(1), pages 1-8, April.
    5. Yueshen Wu & Zhan Jiang & Xu Lu & Yongye Liang & Hailiang Wang, 2019. "Domino electroreduction of CO2 to methanol on a molecular catalyst," Nature, Nature, vol. 575(7784), pages 639-642, November.
    6. Pamela A. Williams & Jose Cosme & Alison Ward & Hayley C. Angove & Dijana Matak Vinković & Harren Jhoti, 2003. "Crystal structure of human cytochrome P450 2C9 with bound warfarin," Nature, Nature, vol. 424(6947), pages 464-468, July.
    7. Shubo Tian & Qiang Fu & Wenxing Chen & Quanchen Feng & Zheng Chen & Jian Zhang & Weng-Chon Cheong & Rong Yu & Lin Gu & Juncai Dong & Jun Luo & Chen Chen & Qing Peng & Claudia Draxl & Dingsheng Wang & , 2018. "Carbon nitride supported Fe2 cluster catalysts with superior performance for alkene epoxidation," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    8. Boyuan Shen & Huiqiu Wang & Hao Xiong & Xiao Chen & Eric G. T. Bosch & Ivan Lazić & Weizhong Qian & Fei Wei, 2022. "Atomic imaging of zeolite-confined single molecules by electron microscopy," Nature, Nature, vol. 607(7920), pages 703-707, July.
    9. Yu Zhou & Xinyu Zhang & Guan Sheng & Shengda Wang & Muqing Chen & Guilin Zhuang & Yihan Zhu & Pingwu Du, 2023. "A metal-free photoactive nitrogen-doped carbon nanosolenoid with broad absorption in visible region for efficient photocatalysis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
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