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Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation

Author

Listed:
  • Ying Wang

    (Hung Hom)

  • Vinod K. Paidi

    (European Synchrotron Radiation Facility)

  • Weizhen Wang

    (The Hong Kong Polytechnic University, Hung Hom)

  • Yong Wang

    (Hung Hom)

  • Guangri Jia

    (Jilin University)

  • Tingyu Yan

    (Harbin Normal University)

  • Xiaoqiang Cui

    (Jilin University)

  • Songhua Cai

    (The Hong Kong Polytechnic University, Hung Hom)

  • Jingxiang Zhao

    (Harbin Normal University)

  • Kug-Seung Lee

    (Pohang University of Science and Technology (POSTECH))

  • Lawrence Yoon Suk Lee

    (Hung Hom
    Hung Hom)

  • Kwok-Yin Wong

    (Hung Hom)

Abstract

The precise design of single-atom nanozymes (SAzymes) and understanding of their biocatalytic mechanisms hold great promise for developing ideal bio-enzyme substitutes. While considerable efforts have been directed towards mimicking partial bio-inspired structures, the integration of heterogeneous SAzymes configurations and homogeneous enzyme-like mechanism remains an enormous challenge. Here, we show a spatial engineering strategy to fabricate dual-sites SAzymes with atomic Fe active center and adjacent Cu sites. Compared to planar Fe–Cu dual-atomic sites, vertically stacked Fe–Cu geometry in FePc@2D-Cu–N–C possesses highly optimized scaffolds, favorable substrate affinity, and fast electron transfer. These characteristics of FePc@2D-Cu–N–C SAzyme induces biomimetic O2 activation through homogenous enzymatic pathway, resembling functional and mechanistic similarity to natural cytochrome c oxidase. Furthermore, it presents an appealing alternative of cytochrome P450 3A4 for drug metabolism and drug–drug interaction. These findings are expected to deepen the fundamental understanding of atomic-level design in next-generation bio-inspired nanozymes.

Suggested Citation

  • Ying Wang & Vinod K. Paidi & Weizhen Wang & Yong Wang & Guangri Jia & Tingyu Yan & Xiaoqiang Cui & Songhua Cai & Jingxiang Zhao & Kug-Seung Lee & Lawrence Yoon Suk Lee & Kwok-Yin Wong, 2024. "Spatial engineering of single-atom Fe adjacent to Cu-assisted nanozymes for biomimetic O2 activation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46528-w
    DOI: 10.1038/s41467-024-46528-w
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