Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations
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DOI: 10.1038/s41467-024-47398-y
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- Linfeng Gao & Yiran Guo & Mahamaya Biswal & Jiuwei Lu & Jiekai Yin & Jian Fang & Xinyi Chen & Zengyu Shao & Mengjiang Huang & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2022. "Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
- Xue Guo & Ling Wang & Jie Li & Zhanyu Ding & Jianxiong Xiao & Xiaotong Yin & Shuang He & Pan Shi & Liping Dong & Guohong Li & Changlin Tian & Jiawei Wang & Yao Cong & Yanhui Xu, 2015. "Structural insight into autoinhibition and histone H3-induced activation of DNMT3A," Nature, Nature, vol. 517(7536), pages 640-644, January.
- Junji Koya & Keisuke Kataoka & Tomohiko Sato & Masashige Bando & Yuki Kato & Takako Tsuruta-Kishino & Hiroshi Kobayashi & Kensuke Narukawa & Hiroyuki Miyoshi & Katsuhiko Shirahige & Mineo Kurokawa, 2016. "DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation," Nature Communications, Nature, vol. 7(1), pages 1-14, April.
- Linfeng Gao & Max Emperle & Yiran Guo & Sara A. Grimm & Wendan Ren & Sabrina Adam & Hidetaka Uryu & Zhi-Min Zhang & Dongliang Chen & Jiekai Yin & Michael Dukatz & Hiwot Anteneh & Renata Z. Jurkowska &, 2020. "Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
- Ting-Hai Xu & Minmin Liu & X. Edward Zhou & Gangning Liang & Gongpu Zhao & H. Eric Xu & Karsten Melcher & Peter A. Jones, 2020. "Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B," Nature, Nature, vol. 586(7827), pages 151-155, October.
- Hiwot Anteneh & Jian Fang & Jikui Song, 2020. "Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
- Zhi-Min Zhang & Rui Lu & Pengcheng Wang & Yang Yu & Dongliang Chen & Linfeng Gao & Shuo Liu & Debin Ji & Scott B Rothbart & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2018. "Structural basis for DNMT3A-mediated de novo DNA methylation," Nature, Nature, vol. 554(7692), pages 387-391, February.
- Guo-Liang Xu & Timothy H. Bestor & Déborah Bourc'his & Chih-Lin Hsieh & Niels Tommerup & Merete Bugge & Maj Hulten & Xiaoyan Qu & James J. Russo & Evani Viegas-Péquignot, 1999. "Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene," Nature, Nature, vol. 402(6758), pages 187-191, November.
- Daniel N. Weinberg & Simon Papillon-Cavanagh & Haifen Chen & Yuan Yue & Xiao Chen & Kartik N. Rajagopalan & Cynthia Horth & John T. McGuire & Xinjing Xu & Hamid Nikbakht & Agata E. Lemiesz & Dylan M. , 2019. "The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape," Nature, Nature, vol. 573(7773), pages 281-286, September.
- Da Jia & Renata Z. Jurkowska & Xing Zhang & Albert Jeltsch & Xiaodong Cheng, 2007. "Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation," Nature, Nature, vol. 449(7159), pages 248-251, September.
- Déborah Bourc'his & Timothy H. Bestor, 2004. "Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L," Nature, Nature, vol. 431(7004), pages 96-99, September.
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