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Structural basis for DNMT3A-mediated de novo DNA methylation

Author

Listed:
  • Zhi-Min Zhang

    (University of California
    Jinan University)

  • Rui Lu

    (The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
    University of North Carolina at Chapel Hill School of Medicine)

  • Pengcheng Wang

    (Environmental Toxicology Graduate Program, University of California)

  • Yang Yu

    (Environmental Toxicology Graduate Program, University of California)

  • Dongliang Chen

    (The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
    University of North Carolina at Chapel Hill School of Medicine)

  • Linfeng Gao

    (Environmental Toxicology Graduate Program, University of California)

  • Shuo Liu

    (Environmental Toxicology Graduate Program, University of California)

  • Debin Ji

    (University of California)

  • Scott B Rothbart

    (University of North Carolina at Chapel Hill School of Medicine
    Center for Epigenetics, Van Andel Research Institute)

  • Yinsheng Wang

    (Environmental Toxicology Graduate Program, University of California
    University of California)

  • Gang Greg Wang

    (The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine
    University of North Carolina at Chapel Hill School of Medicine)

  • Jikui Song

    (University of California
    Environmental Toxicology Graduate Program, University of California)

Abstract

A crystal structure of DNMT3A and its regulatory partner DNMT3L bound to DNA reveals the mechanistic basis for DNMT3A-mediated DNA methylation and establishes its aetiological link to human disease.

Suggested Citation

  • Zhi-Min Zhang & Rui Lu & Pengcheng Wang & Yang Yu & Dongliang Chen & Linfeng Gao & Shuo Liu & Debin Ji & Scott B Rothbart & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2018. "Structural basis for DNMT3A-mediated de novo DNA methylation," Nature, Nature, vol. 554(7692), pages 387-391, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7692:d:10.1038_nature25477
    DOI: 10.1038/nature25477
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    Citations

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    Cited by:

    1. Steffen Mueller & Gail Dennison & Shujun Liu, 2021. "An Assessment on Ethanol-Blended Gasoline/Diesel Fuels on Cancer Risk and Mortality," IJERPH, MDPI, vol. 18(13), pages 1-23, June.
    2. Amika Kikuchi & Hiroki Onoda & Kosuke Yamaguchi & Satomi Kori & Shun Matsuzawa & Yoshie Chiba & Shota Tanimoto & Sae Yoshimi & Hiroki Sato & Atsushi Yamagata & Mikako Shirouzu & Naruhiko Adachi & Jafa, 2022. "Structural basis for activation of DNMT1," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Linfeng Gao & Yiran Guo & Mahamaya Biswal & Jiuwei Lu & Jiekai Yin & Jian Fang & Xinyi Chen & Zengyu Shao & Mengjiang Huang & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2022. "Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Zengyu Shao & Jiuwei Lu & Nelli Khudaverdyan & Jikui Song, 2024. "Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Jian Fang & Jianjun Jiang & Sarah M. Leichter & Jie Liu & Mahamaya Biswal & Nelli Khudaverdyan & Xuehua Zhong & Jikui Song, 2022. "Mechanistic basis for maintenance of CHG DNA methylation in plants," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Jiuwei Lu & Yiran Guo & Jiekai Yin & Jianbin Chen & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2024. "Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    7. Zheng Zhao & Liang Li & Ruichen Zeng & Liangguan Lin & Dongwei Yuan & Yejie Wen & Na Li & Yingying Cui & Shiming Zhu & Zhi-Min Zhang & Sheng Li & Chonghua Ren, 2023. "5mC modification orchestrates choriogenesis and fertilization by preventing prolonged ftz-f1 expression," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    8. Xinyi Chen & Yiran Guo & Ting Zhao & Jiuwei Lu & Jian Fang & Yinsheng Wang & Gang Greg Wang & Jikui Song, 2024. "Structural basis for the H2AK119ub1-specific DNMT3A-nucleosome interaction," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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